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Thyroid Emergencies

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Thyroid Disorders

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Abstract

Thyroid gland plays a pivotal role in keeping biochemical harmony and maintaining appropriate functioning of vital organs. Therefore any abnormality in thyroid hormone regulation, can lead to wide ranging detrimental effects. This chapter is assigned for identifying and managing thyroid conditions, which require emergent or urgent interventions. It’s not only the biochemical status of the patient which determines this, but also the clinical presentation can make it urgent vs emergent. This is discussed in condition such as Thyroid storm and myxedema coma. Also, thyroid hormone abnormalities during pregnancy, ICU setting, involving vital organ (CNS, cardiovascular) or related to medicine use (lithium/amiodarone) may pose certain acute management challenges and hence discussed in this chapter.

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References

  1. Sarlis NJ, Gourgiotis L. Thyroid emergencies. Rev Endocr Metab Disord. 2003;4:129.

    Article  PubMed  Google Scholar 

  2. Ngo SY, Chew HC. When the storm passes unnoticed – a case series of thyroid storm. Resuscitation. 2007;73:485.

    Article  PubMed  Google Scholar 

  3. Nayak B, Burman K. Thyrotoxicosis and thyroid storm. Endocrinol Metab Clin North Am. 2006;35:663.

    Article  CAS  PubMed  Google Scholar 

  4. Burch HB, Wartofsky L. Life-threatening thyrotoxicosis. Thyroid storm. Endocrinol Metab Clin North Am. 1993;22:263.

    CAS  PubMed  Google Scholar 

  5. Bahn Chair RS, Burch HB, Cooper DS, et al. Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid. 2011;21:593.

    Article  PubMed  CAS  Google Scholar 

  6. Cooper DS, Saxe VC, Meskell M, et al. Acute effects of propylthiouracil (PTU) on thyroidal iodide organification and peripheral iodothyronine deiodination: correlation with serum PTU levels measured by radioimmunoassay. J Clin Endocrinol Metab. 1982;54:101.

    Article  CAS  PubMed  Google Scholar 

  7. Das G, Krieger M. Treatment of thyrotoxic storm with intravenous administration of propranolol. Ann Intern Med. 1969;70:985.

    Article  CAS  PubMed  Google Scholar 

  8. Benua RS, Becker DV, Hurley JR. Thyroid storm. In: Bardin CW, editor. Current therapy in endocrinology and metabolism. St. Louis: Mosby; 1994. p. 75.

    Google Scholar 

  9. Roti E, Robuschi G, Gardini E, et al. Comparison of methimazole, methimazole and sodium ipodate, and methimazole and saturated solution of potassium iodide in the early treatment of hyperthyroid Graves’ disease. Clin Endocrinol (Oxf). 1988;28:305.

    Article  CAS  Google Scholar 

  10. Nabil N, Miner DJ, Amatruda JM. Methimazole: an alternative route of administration. J Clin Endocrinol Metab. 1982;54:180.

    Article  CAS  PubMed  Google Scholar 

  11. Mazzaferri EL, Skillman TG. Thyroid storm. A review of 22 episodes with special emphasis on the use of guanethidine. Arch Intern Med. 1969;124:684.

    Article  CAS  PubMed  Google Scholar 

  12. Sherman SI, Simonson L, Ladenson PW. Clinical and socioeconomic predispositions to complicated thyrotoxicosis: a predictable and preventable syndrome? Am J Med. 1996;101:192.

    Article  CAS  PubMed  Google Scholar 

  13. Mazonson PD, Williams ML, Cantley LK, et al. Myxedema coma during long-term amiodarone therapy. Am J Med. 1984;77:751.

    Article  CAS  PubMed  Google Scholar 

  14. Waldman SA, Park D. Myxedema coma associated with lithium therapy. Am J Med. 1989;87:355.

    Article  CAS  PubMed  Google Scholar 

  15. Hylander B, Rosenqvist U. Treatment of myxoedema coma – factors associated with fatal outcome. Acta Endocrinol (Copenh). 1985;108:65.

    CAS  Google Scholar 

  16. Dutta P, Bhansali A, Masoodi SR, et al. Predictors of outcome in myxoedema coma: a study from a tertiary care centre. Crit Care. 2008;12:R1.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Beynon J, Akhtar S, Kearney T. Predictors of outcome in myxoedema coma. Crit Care. 2008;12:111.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Klein I. Thyroid hormone and the cardiovascular system. Am J Med. 1990;88:631.

    Article  CAS  PubMed  Google Scholar 

  19. Westphal SA. Unusual presentations of hypothyroidism. Am J Med Sci. 1997;314:333.

    CAS  PubMed  Google Scholar 

  20. Kwaku MP, Burman KD. Myxedema coma. J Intensive Care Med. 2007;22:224.

    Article  PubMed  Google Scholar 

  21. Arlot S, Debussche X, Lalau JD, et al. Myxoedema coma: response of thyroid hormones with oral and intravenous high-dose L-thyroxine treatment. Intensive Care Med. 1991;17:16.

    Article  CAS  PubMed  Google Scholar 

  22. MacKerrow SD, Osborn LA, Levy H, et al. Myxedema-associated cardiogenic shock treated with intravenous triiodothyronine. Ann Intern Med. 1992;117:1014.

    Article  CAS  PubMed  Google Scholar 

  23. Holvey DN, Goodner CJ, Nicoloff JT. Treatment of Myxedema coma with intravenous thyroxine. Arch Intern Med. 1964;113:89.

    Article  CAS  PubMed  Google Scholar 

  24. Yamamoto T, Fukuyama J, Fujiyoshi A. Factors associated with mortality of myxedema coma: report of eight cases and literature survey. Thyroid. 1999;9:1167.

    Article  CAS  PubMed  Google Scholar 

  25. Rodríguez I, Fluiters E, Pérez-Méndez LF, et al. Factors associated with mortality of patients with myxoedema coma: prospective study in 11 cases treated in a single institution. J Endocrinol. 2004;180:347.

    Article  PubMed  Google Scholar 

  26. Foulds N, Walpole I, Elmslie F, Mansour S. Carbimazole embryopathy: an emerging phenotype. Am J Med Genet A. 2005;132A:130.

    Article  PubMed  Google Scholar 

  27. Bowman P, Osborne NJ, Sturley R, Vaidya B. Carbimazole embryopathy: implications for the choice of antithyroid drugs in pregnancy. QJM. 2012;105:189.

    Article  CAS  PubMed  Google Scholar 

  28. Wilson LC, Kerr BA, Wilkinson R, et al. Choanal atresia and hypothelia following methimazole exposure in utero: a second report. Am J Med Genet. 1998;75:220.

    Article  CAS  PubMed  Google Scholar 

  29. Di Gianantonio E, Schaefer C, Mastroiacovo PP, et al. Adverse effects of prenatal methimazole exposure. Teratology. 2001;64:262.

    Article  PubMed  Google Scholar 

  30. Wing DA, Millar LK, Koonings PP, et al. A comparison of propylthiouracil versus methimazole in the treatment of hyperthyroidism in pregnancy. Am J Obstet Gynecol. 1994;170:90.

    Article  CAS  PubMed  Google Scholar 

  31. Bowman P, Vaidya B. Suspected spontaneous reports of birth defects in the UK associated with the use of carbimazole and propylthiouracil in pregnancy. J Thyroid Res. 2011;2011:235130.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Butters L, Kennedy S, Rubin PC. Atenolol in essential hypertension during pregnancy. BMJ. 1990;301:587.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Lydakis C, Lip GY, Beevers M, Beevers DG. Atenolol and fetal growth in pregnancies complicated by hypertension. Am J Hypertens. 1999;12:541.

    Article  CAS  PubMed  Google Scholar 

  34. Lip GY, Beevers M, Churchill D, et al. Effect of atenolol on birth weight. Am J Cardiol. 1997;79:1436.

    Article  CAS  PubMed  Google Scholar 

  35. Adali E, Yildizhan R, Kolusari A, et al. The use of plasmapheresis for rapid hormonal control in severe hyperthyroidism caused by a partial molar pregnancy. Arch Gynecol Obstet. 2009;279:569.

    Article  CAS  PubMed  Google Scholar 

  36. Azezli A, Bayraktaroglu T, Topuz S, Kalayoglu-Besisik S. Hyperthyroidism in molar pregnancy: rapid preoperative preparation by plasmapheresis and complete improvement after evacuation. Transfus Apher Sci. 2007;36:87.

    Article  PubMed  Google Scholar 

  37. Martin FI, Deam DR. Hyperthyroidism in elderly hospitalised patients. Clinical features and treatment outcomes. Med J Aust. 1996;164:200.

    CAS  PubMed  Google Scholar 

  38. Yudiarto FL, Muliadi L, Moeljanto D, Hartono B. Neuropsychological findings in hyperthyroid patients. Acta Med Indones. 2006;38:6.

    PubMed  Google Scholar 

  39. Wu T, Flowers JW, Tudiver F, et al. Subclinical thyroid disorders and cognitive performance among adolescents in the United States. BMC Pediatr. 2006;6:12.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Li Voon Chong JS, Lecky BR, Macfarlane IA. Recurrent encephalopathy and generalised seizures associated with relapses of thyrotoxicosis. Int J Clin Pract. 2000;54:621.

    CAS  PubMed  Google Scholar 

  41. Safe AF, Griffiths KD, Maxwell RT. Thyrotoxic crisis presenting as status epilepticus. Postgrad Med J. 1990;66:150.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Jabbari B, Huott AD. Seizures in thyrotoxicosis. Epilepsia. 1980;21:91. Lee TG, Ha CK, Lim BH. Thyroid storm presenting as status epilepticus and stroke. Postgrad Med J. 1997;73:61.

    Google Scholar 

  43. Newcomer J, Haire W, Hartman CR. Coma and thyrotoxicosis. Ann Neurol. 1983;14:689.

    Article  CAS  PubMed  Google Scholar 

  44. Jabbari B, Huott AD. Seizures in thyrotoxicosis. Epilepsia. 1980;21:91.

    Article  CAS  PubMed  Google Scholar 

  45. Lee TG, Ha CK, Lim BH. Thyroid storm presenting as status epilepticus and stroke. Postgrad Med J. 1997;73:61.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Stern RA, Robinson B, Thorner AR, et al. A survey study of neuropsychiatric complaints in patients with Graves’ disease. J Neuropsychiatry Clin Neurosci. 1996;8:181.

    Article  CAS  PubMed  Google Scholar 

  47. Fukui T, Hasegawa Y, Takenaka H. Hyperthyroid dementia: clinicoradiological findings and response to treatment. J Neurol Sci. 2001;184:81.

    Article  CAS  PubMed  Google Scholar 

  48. Duyff RF, Van den Bosch J, Laman DM, et al. Neuromuscular findings in thyroid dysfunction: a prospective clinical and electrodiagnostic study. J Neurol Neurosurg Psychiatry. 2000;68:750.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Teoh HL, Lim EC. Platysmal myoclonus in subclinical hyperthyroidism. Mov Disord. 2005;20:1064.

    Article  PubMed  Google Scholar 

  50. Loh LM, Hum AY, Teoh HL, Lim EC. Graves’ disease associated with spasmodic truncal flexion. Parkinsonism Relat Disord. 2005;11:117.

    Article  PubMed  Google Scholar 

  51. Ristić AJ, Svetel M, Dragasević N, et al. Bilateral chorea-ballism associated with hyperthyroidism. Mov Disord. 2004;19:982.

    Article  PubMed  Google Scholar 

  52. Fischbeck KH, Layzer RB. Paroxysmal choreoathetosis associated with thyrotosicosis. Ann Neurol. 1979;6:453.

    Article  CAS  PubMed  Google Scholar 

  53. Yen DJ, Shan DE, Lu SR. Hyperthyroidism presenting as recurrent short paroxysmal kinesigenic dyskinesia. Mov Disord. 1998;13:361.

    Article  CAS  PubMed  Google Scholar 

  54. Puri V, Chaudhry N. Paroxysmal kinesigenic dyskinesia manifestation of hyperthyroidism. Neurol India. 2004;52:102.

    CAS  PubMed  Google Scholar 

  55. Klawans Jr HL, Shenker DM. Observations on the dopaminergic nature of hyperthyroid chorea. J Neural Transm. 1972;33:73.

    Article  PubMed  Google Scholar 

  56. Sheu JJ, Kang JH, Lin HC, Lin HC. Hyperthyroidism and risk of ischemic stroke in young adults: a 5-year follow-up study. Stroke. 2010;41:961.

    Article  PubMed  Google Scholar 

  57. Squizzato A, Gerdes VE, Brandjes DP, et al. Thyroid diseases and cerebrovascular disease. Stroke. 2005;36:2302.

    Article  CAS  PubMed  Google Scholar 

  58. Ra CS, Lui CC, Liang CL, et al. Superior sagittal sinus thrombosis induced by thyrotoxicosis. Case report. J Neurosurg. 2001;94:130.

    Article  CAS  PubMed  Google Scholar 

  59. Siegert CE, Smelt AH, de Bruin TW. Superior sagittal sinus thrombosis and thyrotoxicosis. Possible association in two cases. Stroke. 1995;26:496.

    Article  CAS  PubMed  Google Scholar 

  60. Molloy E, Cahill M, O’Hare JA. Cerebral venous sinus thrombosis precipitated by Graves’ disease and Factor V Leiden mutation. Ir Med J. 2003;96:46.

    CAS  PubMed  Google Scholar 

  61. Verberne HJ, Fliers E, Prummel MF, et al. Thyrotoxicosis as a predisposing factor for cerebral venous thrombosis. Thyroid. 2000;10:607.

    Article  CAS  PubMed  Google Scholar 

  62. Campos CR, Basso M, Evaristo EF, et al. Bilateral carotid artery dissection with thyrotoxicosis. Neurology. 2004;63:2443.

    Article  CAS  PubMed  Google Scholar 

  63. Nakamura K, Yanaka K, Ihara S, Nose T. Multiple intracranial arterial stenoses around the circle of Willis in association with Graves’ disease: report of two cases. Neurosurgery. 2003;53:1210.

    Article  PubMed  Google Scholar 

  64. Thomas RD, Croft DN. Thyrotoxicosis and giant-cell arteritis. Br Med J. 1974;2:408.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Marongiu F, Conti M, Murtas ML, et al. Anticardiolipin antibodies in Grave’s disease: relationship with thrombin activity in vivo. Thromb Res. 1991;64:745.

    Article  CAS  PubMed  Google Scholar 

  66. Bowness P, Shotliff K, Middlemiss A, Myles AB. Prevalence of hypothyroidism in patients with polymyalgia rheumatica and giant cell arteritis. Br J Rheumatol. 1991;30:349.

    Article  CAS  PubMed  Google Scholar 

  67. Hofbauer LC, Spitzweg C, Heufelder AE. Graves’ disease associated with the primary antiphospholipid syndrome. J Rheumatol. 1996;23:1435.

    CAS  PubMed  Google Scholar 

  68. Ramsay ID. Electromyography in thyrotoxicosis. Q J Med. 1965;34:255.

    CAS  PubMed  Google Scholar 

  69. Havard CW, Campbell ED, Ross HB. Electromyographic and histological findings in the muscles of patients with thyrotoxicosis. Q J Med. 1963;32:145.

    CAS  PubMed  Google Scholar 

  70. Sinclair C, Gilchrist JM, Hennessey JV, Kandula M. Muscle carnitine in hypo- and hyperthyroidism. Muscle Nerve. 2005;32:357.

    Article  CAS  PubMed  Google Scholar 

  71. Kaminski HJ, Ruff RL. Endocrine myopathies (hyper- and hypofunction of adrenal, thyroid, pistuitary, and parathyroid glands and iatrogenic corticosteroid myopathy. In: Myology, 2nd ed, Enngel, AG, Franzini-Armstrong, C (Eds), McGraw-Hill, New York 1994. p.1726

    Google Scholar 

  72. Horak HA, Pourmand R. Endocrine myopathies. Neurol Clin. 2000;18:203.

    Article  CAS  PubMed  Google Scholar 

  73. Kissel JT, Mendell JR. The endocrine myopathies. In: Rowland LP, Dimauro S, editors. Handbook of clinical neurology myopathies. New York: Elsevier Science; 1992. p. 527.

    Google Scholar 

  74. Erkintalo M, Bendahan D, Mattéi JP, et al. Reduced metabolic efficiency of skeletal muscle energetics in hyperthyroid patients evidenced quantitatively by in vivo phosphorus-31 magnetic resonance spectroscopy. Metabolism. 1998;47:769.

    Article  CAS  PubMed  Google Scholar 

  75. Bennett WR, Huston DP. Rhabdomyolysis in thyroid storm. Am J Med. 1984;77:733.

    Article  CAS  PubMed  Google Scholar 

  76. Lichtstein DM, Arteaga RB. Rhabdomyolysis associated with hyperthyroidism. Am J Med Sci. 2006;332:103.

    Article  PubMed  Google Scholar 

  77. Alshanti M, Eledrisi MS, Jones E. Rhabdomyolysis associated with hyperthyroidism. Am J Emerg Med. 2001;19:317.

    Article  CAS  PubMed  Google Scholar 

  78. Roquer J, Cano JF. Mononeuropathies in thyrotoxicosis. J Neurol Neurosurg Psychiatry. 1992;55:332.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Fisher M, Mateer JE, Ullrich I, Gutrecht JA. Pyramidal tract deficits and polyneuropathy in hyperthyroidism, Combination clinically mimicking amyotrophic lateral sclerosis. Am J Med. 1985;78:1041.

    Article  CAS  PubMed  Google Scholar 

  80. Feibel JH, Campa JF. Thyrotoxic neuropathy (Basedow’s paraplegia). (. J Neurol Neurosurg Psychiatry. 1976;39:491.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Sözay S, Gökçe-Kutsal Y, Celiker R, et al. Neuroelectrophysiological evaluation of untreated hyperthyroid patients. Thyroidology. 1994;6:55.

    PubMed  Google Scholar 

  82. Pandit L, Shankar SK, Gayathri N, Pandit A. Acute thyrotoxic neuropathy–Basedow’s paraplegia revisited. J Neurol Sci. 1998;155:211.

    Article  CAS  PubMed  Google Scholar 

  83. Bronsky D, Kaganiec GI, et al. An association between the Guillain-barr’e syndrome and hyperthyroidism. Am J Med Sci. 1964;247:196.

    Article  CAS  PubMed  Google Scholar 

  84. Kiessling WR, Pflughaupt KW, Ricker K, et al. Thyroid function and circulating antithyroid antibodies in myasthenia gravis. Neurology. 1981;31:771.

    Article  CAS  PubMed  Google Scholar 

  85. Ratanakorn D, Vejjajiva A. Long-term follow-up of myasthenia gravis patients with hyperthyroidism. Acta Neurol Scand. 2002;106:93.

    Article  CAS  PubMed  Google Scholar 

  86. Weissel M, Mayr N, Zeitlhofer J. Clinical significance of autoimmune thyroid disease in myasthenia gravis. Exp Clin Endocrinol Diabetes. 2000;108:63.

    CAS  PubMed  Google Scholar 

  87. Sekiguchi Y, Hara Y, Takahashi M, Hirata Y. Reverse ‘see-saw’ relationship between Graves’ disease and myasthenia gravis; clinical and immunological studies. J Med Dent Sci. 2005;52:43.

    PubMed  Google Scholar 

  88. Téllez-Zenteno JF, Cardenas G, Estañol B, et al. Associated conditions in myasthenia gravis: response to thymectomy. Eur J Neurol. 2004;11:767.

    Article  PubMed  Google Scholar 

  89. Ríos A, Rodríguez JM, Canteras M, et al. Surgical management of multinodular goiter with compression symptoms. Arch Surg. 2005;140:49.

    Article  PubMed  Google Scholar 

  90. Anders HJ. Compression syndromes caused by substernal goitres. Postgrad Med J. 1998;74:327.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  91. Davis PJ, Davis FB. Nongenomic actions of thyroid hormone on the heart. Thyroid. 2002;12:459.

    Article  CAS  PubMed  Google Scholar 

  92. Brent GA. The molecular basis of thyroid hormone action. N Engl J Med. 1994;331:847.

    Article  CAS  PubMed  Google Scholar 

  93. Klein I. Endocrine disorders and cardiovascular disease. In: Bonow RO, Mann DL, Zipes DP, Libby P, editors. Braunwald’s heart disease: a textbook of cardiovascular medicine. 9th ed. Philadelphia: Elsevier Saunders; 2012. p. 1829.

    Chapter  Google Scholar 

  94. Iglesias P, Acosta M, Sánchez R, et al. Ambulatory blood pressure monitoring in patients with hyperthyroidism before and after control of thyroid function. Clin Endocrinol (Oxf). 2005;63:66.

    Article  CAS  Google Scholar 

  95. Wustmann K, Kucera JP, Zanchi A, et al. Activation of electrical triggers of atrial fibrillation in hyperthyroidism. J Clin Endocrinol Metab. 2008;93:2104.

    Article  CAS  PubMed  Google Scholar 

  96. Siu CW, Yeung CY, Lau CP, et al. Incidence, clinical characteristics and outcome of congestive heart failure as the initial presentation in patients with primary hyperthyroidism. Heart. 2007;93:483.

    Article  PubMed  PubMed Central  Google Scholar 

  97. Roti E, Uberti ED. Iodine excess and hyperthyroidism. Thyroid. 2001;11:493.

    Article  CAS  PubMed  Google Scholar 

  98. Stanbury JB, Ermans AE, Bourdoux P, et al. Iodine-induced hyperthyroidism : occurrence and epidemiology. Thyroid. 1998;8:83.

    Article  CAS  PubMed  Google Scholar 

  99. Skare S, Frey HM. Iodine induced thyrotoxicosis in apparently normal thyroid glands. Acta Endocrinol (Copenh). 1980;94:332.

    CAS  Google Scholar 

  100. Hintze G, Blombach O, Fink H, et al. Risk of iodine-induced thyrotoxicosis after coronary angiography: an investigation in 788 unselected subjects. Eur J Endocrinol. 1999;140:264.

    Article  CAS  PubMed  Google Scholar 

  101. Fradkin JE, Wolff J. Iodide-induced thyrotoxicosis. Medicine (Baltimore). 1983;62:1.

    Article  CAS  Google Scholar 

  102. Rhee CM, Bhan I, Alexander EK, Brunelli SM. Association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism. Arch Intern Med. 2012;172:153.

    Article  CAS  PubMed  Google Scholar 

  103. Burman KD, Wartofsky L. Iodine effects on the thyroid gland: biochemical and clinical aspects. Rev Endocr Metab Disord. 2000;1:19.

    Article  CAS  PubMed  Google Scholar 

  104. Clark OH, Cavalieri RR, Moser C, Ingbar SH. Iodide-induced hypothyroidism in patients after thyroid resection. Eur J Clin Invest. 1990;20:573.

    Article  CAS  PubMed  Google Scholar 

  105. Roti E, Minelli R, Gardini E, et al. Impaired intrathyroidal iodine organification and iodine-induced hypothyroidism in euthyroid women with a previous episode of postpartum thyroiditis. J Clin Endocrinol Metab. 1991;73:958.

    Article  CAS  PubMed  Google Scholar 

  106. Kämpe O, Jansson R, Karlsson FA. Effects of L-thyroxine and iodide on the development of autoimmune postpartum thyroiditis. J Clin Endocrinol Metab. 1990;70:1014.

    Article  PubMed  Google Scholar 

  107. Costigan DC, Holland FJ, Daneman D, et al. Amiodarone therapy effects on childhood thyroid function. Pediatrics. 1986;77:703.

    CAS  PubMed  Google Scholar 

  108. Alexandrides T, Georgopoulos N, Yarmenitis S, Vagenakis AG. Increased sensitivity to the inhibitory effect of excess iodide on thyroid function in patients with beta-thalassemia major and iron overload and the subsequent development of hypothyroidism. Eur J Endocrinol. 2000;143:319.

    Article  CAS  PubMed  Google Scholar 

  109. Burrow GN, Burke WR, Himmelhoch JM, et al. Effect of lithium on thyroid function. J Clin Endocrinol Metab. 1971;32:647.

    Article  CAS  PubMed  Google Scholar 

  110. Bagchi N, Brown TR, Mack RE. Studies on the mechanism of inhibition of thyroid function by lithium. Biochim Biophys Acta. 1978;542:163.

    Article  CAS  PubMed  Google Scholar 

  111. Berens SC, Bernstein RS, Robbins J, Wolff J. Antithyroid effects of lithium. J Clin Invest. 1970;49:1357.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  112. Kirov G, Tredget J, John R, et al. A cross-sectional and a prospective study of thyroid disorders in lithium-treated patients. J Affect Disord. 2005;87:313.

    Article  CAS  PubMed  Google Scholar 

  113. Bocchetta A, Loviselli A. Lithium treatment and thyroid abnormalities. Clin Pract Epidemiol Ment Health. 2006;2:23.

    Article  PubMed  PubMed Central  Google Scholar 

  114. Van Melick EJ, Wilting I, Meinders AE, Egberts TC. Prevalence and determinants of thyroid disorders in elderly patients with affective disorders: lithium and nonlithium patients. Am J Geriatr Psychiatry. 2010;18:395.

    Article  PubMed  Google Scholar 

  115. Ng YW, Tiu SC, Choi KL, et al. Use of lithium in the treatment of thyrotoxicosis. Hong Kong Med J. 2006;12:254.

    CAS  PubMed  Google Scholar 

  116. Kristensen O, Andersen HH, Pallisgaard G. Lithium carbonate in the treatment of thyrotoxicosis. A controlled trial. Lancet. 1976;1:603.

    Article  CAS  PubMed  Google Scholar 

  117. Miller KK, Daniels GH. Association between lithium use and thyrotoxicosis caused by silent thyroiditis. Clin Endocrinol (Oxf). 2001;55:501.

    Article  CAS  Google Scholar 

  118. Lazarus JH. Lithium and thyroid. Best Pract Res Clin Endocrinol Metab. 2009;23:723.

    Article  CAS  PubMed  Google Scholar 

  119. Perrild H, Hegedüs L, Baastrup PC, et al. Thyroid function and ultrasonically determined thyroid size in patients receiving long-term lithium treatment. Am J Psychiatry. 1990;147:1518.

    Article  CAS  PubMed  Google Scholar 

  120. Lee S, Chow CC, Wing YK, Shek CC. Thyroid abnormalities during chronic lithium treatment in Hong Kong Chinese: a controlled study. J Affect Disord. 1992;26:173.

    Article  CAS  PubMed  Google Scholar 

  121. Bocchetta A, Bernardi F, Pedditzi M, et al. Thyroid abnormalities during lithium treatment. Acta Psychiatr Scand. 1991;83:193.

    Article  CAS  PubMed  Google Scholar 

  122. Batcher EL, Tang XC, Singh BN, et al. Thyroid function abnormalities during amiodarone therapy for persistent atrial fibrillation. Am J Med. 2007;120:880.

    Article  CAS  PubMed  Google Scholar 

  123. Tsadok MA, Jackevicius CA, Rahme E, et al. Amiodarone-induced thyroid dysfunction: brand-name versus generic formulations. CMAJ. 2011;183, E817.

    Article  PubMed  PubMed Central  Google Scholar 

  124. Martino E, Safran M, Aghini-Lombardi F, et al. Environmental iodine intake and thyroid dysfunction during chronic amiodarone therapy. Ann Intern Med. 1984;101:28.

    Article  CAS  PubMed  Google Scholar 

  125. Lambert M, Unger J, De Nayer P, et al. Amiodarone-induced thyrotoxicosis suggestive of thyroid damage. J Endocrinol Invest. 1990;13:527.

    Article  CAS  PubMed  Google Scholar 

  126. Bartalena L, Brogioni S, Grasso L, et al. Treatment of amiodarone-induced thyrotoxicosis, a difficult challenge: results of a prospective study. J Clin Endocrinol Metab. 1996;81:2930.

    CAS  PubMed  Google Scholar 

  127. Martino E, Bartalena L, Bogazzi F, Braverman LE. The effects of amiodarone on the thyroid. Endocr Rev. 2001;22:240.

    CAS  PubMed  Google Scholar 

  128. Bogazzi F, Bartalena L, Martino E. Approach to the patient with amiodarone-induced thyrotoxicosis. J Clin Endocrinol Metab. 2010;95:2529.

    Article  CAS  PubMed  Google Scholar 

  129. Martino E, Aghini-Lombardi F, Mariotti S, et al. Treatment of amiodarone associated thyrotoxicosis by simultaneous administration of potassium perchlorate and methimazole. J Endocrinol Invest. 1986;9:201.

    Article  CAS  PubMed  Google Scholar 

  130. Dickstein G, Shechner C, Adawi F, et al. Lithium treatment in amiodarone-induced thyrotoxicosis. Am J Med. 1997;102:454.

    Article  CAS  PubMed  Google Scholar 

  131. Bogazzi F, Tomisti L, Rossi G, et al. Glucocorticoids are preferable to thionamides as first-line treatment for amiodarone-induced thyrotoxicosis due to destructive thyroiditis: a matched retrospective cohort study. J Clin Endocrinol Metab. 2009;94:3757.

    Article  CAS  PubMed  Google Scholar 

  132. Bogazzi F, Bartalena L, Cosci C, et al. Treatment of type II amiodarone-induced thyrotoxicosis by either iopanoic acid or glucocorticoids: a prospective, randomized study. J Clin Endocrinol Metab. 2003;88:1999.

    Article  CAS  PubMed  Google Scholar 

  133. Shafer RB, Nuttall FQ. Acute changes in thyroid function in patients treated with radioactive iodine. Lancet. 1975;2:635.

    Article  CAS  PubMed  Google Scholar 

  134. Stensvold AD, Jorde R, Sundsfjord J. Late and transient increases in free T4 after radioiodine treatment for Graves’ disease. J Endocrinol Invest. 1997;20:580.

    Article  CAS  PubMed  Google Scholar 

  135. Burch HB, Solomon BL, Cooper DS, et al. The effect of antithyroid drug pretreatment on acute changes in thyroid hormone levels after (131)I ablation for Graves’ disease. J Clin Endocrinol Metab. 2001;86:3016.

    CAS  PubMed  Google Scholar 

  136. Bogazzi F, Bartalena L, Campomori A, et al. Treatment with lithium prevents serum thyroid hormone increase after thionamide withdrawal and radioiodine therapy in patients with Graves’ disease. J Clin Endocrinol Metab. 2002;87:4490.

    Article  CAS  PubMed  Google Scholar 

  137. Shammas NW, Richeson JF, Pomerantz R. Myocardial dysfunction and necrosis after ingestion of thyroid hormone. Am Heart J. 1994;127:232.

    Article  CAS  PubMed  Google Scholar 

  138. Gorman RL, Chamberlain JM, Rose SR, Oderda GM. Massive levothyroxine overdose: high anxiety–low toxicity. Pediatrics. 1988;82:666.

    CAS  PubMed  Google Scholar 

  139. Locker GJ, Kotzmann H, Frey B, et al. Factitious hyperthyroidism causing acute myocardial infarction. Thyroid. 1995;5:465.

    Article  CAS  PubMed  Google Scholar 

  140. Cohen 3rd JH, Ingbar SH, Braverman LE. Thyrotoxicosis due to ingestion of excess thyroid hormone. Endocr Rev. 1989;10:113.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Shaukat Khanum Hospital and Research Center, Lahore, Pakistan

    Syed Abbas Raza MD, FACE

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  1. Syed Abbas Raza MD, FACE
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Correspondence to Syed Abbas Raza MD, FACE .

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  1. Internal Medicine, Al-Mouwasat Hospital, Jubail, Saudi Arabia

    Syed Khalid Imam

  2. School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom

    Shamim I. Ahmad

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Raza, S.A. (2016). Thyroid Emergencies. In: Imam, S., Ahmad, S. (eds) Thyroid Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-25871-3_12

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