Abstract
This chapter deals with the biochemical pharmacology depicted by the plant Artemisia amygdalina. The important biological activities that have been reported till date include those of free radical scavenging potential of the in vitro raised and greenhouse acclimatized plants, anti-inflammatory, and immunomodulatory activity of the plant and the anti-diabetic and anti-hyperlipidemic effect of A. amygdalina. The methanolic extract of the in vitro grown and greenhouse acclimatized plants revealed the highest inhibitory activity, 92.11 and 91.2 % (IC50 = 26.06 µg mL−1), respectively, against DPPH radical. Carrageenan paw edema model has been employed to study the potential of the plant extracts in inflammation in wistar rats. SRBC-specific haemagglutination-titer and DTH assays have been carried out in Balb/C mice for observing the effect of extracts on immune system. The methanolic fraction has been observed to have the maximum effect on the inhibition of paw edema formation with the inhibitory potential of 42.26 %, while in the immunomodulation studies the plant extracts have been found to have the immunosuppressant activity with methanolic fraction again showing the maximum potential for the suppression of both humoral (55.89 and 47.91 %) and cell-mediated immunity (62.27 and 57.21 %). Petroleum ether, ethyl acetate, methanol, and hydroethanolic extracts of A. amygdalina have been tested for their anti-diabetic potentials in diabetic rats. The hydroethanolic and methanolic extracts each at doses of 250 and 500 mg/kg b.w. have significantly reduced glucose levels in diabetic rats. The other biochemical parameters like cholesterol, triglycerides, low density lipoproteins (LDL), serum creatinine, serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), and alkaline phosphatise (ALP), have been found to be reduced by the hydroethanolic and methanolic extracts. The extracts have also shown reduction in the feed and water consumption of diabetic rats when compared with the diabetic control.
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Lone, S.H., Bhat, K.A., Khuroo, M.A. (2015). Biological Profile of Artemisia amygdalina . In: Chemical and Pharmacological Perspective of Artemisia amygdalina. SpringerBriefs in Pharmacology and Toxicology. Springer, Cham. https://doi.org/10.1007/978-3-319-25217-9_5
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DOI: https://doi.org/10.1007/978-3-319-25217-9_5
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