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microRNA and Chronic Lymphocytic Leukemia

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microRNA: Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 889))

Abstract

Expression profiling of microRNAs identified important differences in microRNA expression between CLL samples and normal CD5+ B-cells. Researchers have first discussed the dual role of miRNAs working as tumor suppressors (inhibiting malignant potential) or as oncogenes (activating malignant potential) in CLL pathogenesis. Understanding the roles of miRNAs in leukemic cells brings information on a new layer of gene regulation and also provides new markers for improved diagnosis and prognosis, as well as novel therapeutic options for CLL patients. Herein we will focus on the roles of miRNAs in CLL, highlighting what is already known about their function, proposing a novel model of CLL predisposition and progression, and describing the challenges for the near future.

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Acknowledgments

Dr. Dana Elena Giza was supported in part by CNCS-UEFISCDI project number 22 from 28/08/2013 (PN-II-ID-PCE-2012-4-0018), and by the Romanian National Research Council (CNCS) Complex Exploratory Research Projects (Grant CEEX 187/2006). Dr. Calin is The Alan M. Gewirtz Leukemia & Lymphoma Society Scholar. Work in Dr. Calin’s laboratory is supported in part by the NIH/NCI grants 1UH2TR00943-01 and 1 R01 CA182905-01, The UT MD Anderson Cancer Center SPORE in Melanoma grant from NCI (P50 CA093459), Aim at Melanoma Foundation and the Miriam and Jim Mulva research funds, the Brain SPORE (2P50CA127001), the Center for radiation Oncology Research Project, the Center for Cancer Epigenetics Pilot project, a 2014 Knowledge GAP MDACC grant, a CLL Moonshot pilot project, The UT MD Anderson Cancer Center Duncan Family Institute for Cancer Prevention and Risk Assessment, a SINF grant in colon cancer, the Laura and John Arnold Foundation, the RGK Foundation, and the Estate of C. G. Johnson, Jr. We would like to give special thanks to Dr. Mircea Ionescu for helping with text for editorial assistance.

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Authors and Affiliations

  1. Experimental Therapeutics Department, The University of Texas MD Anderson Cancer Center, Unit 1950, 1515 Holcombe Blvd, Houston, TX, 77030-4009, USA

    Dana Elena Giza & George A. Calin

  2. Department of Hematology, Fundeni Clinical Institute, Bucharest, Romania

    Dana Elena Giza

  3. The RNA Interference and Non-coding RNA Center, MD Anderson Cancer Center, Texas State University, Houston, TX, 77030-4009, USA

    George A. Calin

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  1. Dana Elena Giza
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Correspondence to George A. Calin .

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  1. Department of Physiology, Columbia University Medical Center, New York, New York, USA

    Gaetano Santulli

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Giza, D.E., Calin, G.A. (2015). microRNA and Chronic Lymphocytic Leukemia. In: Santulli, G. (eds) microRNA: Cancer. Advances in Experimental Medicine and Biology, vol 889. Springer, Cham. https://doi.org/10.1007/978-3-319-23730-5_2

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