Abstract
In this paper, we are concerned with the simulation of blood flow and mass transport in vascularized human tissue. Our mathematical model is based on a domain decomposition approach, i.e., we separate the blood vessel network from the tissue and assign different flow and transport models to them. In a second step, the different models are coupled in a weakly consistent way. Flow and transport processes within a 3D tissue are governed by standard equations for porous media flow while within the larger blood vessels less complex 1D models can be used, and the smaller blood vessels can be even treated by 0D lumped parameter models. This results in a 3D-1D-0D coupled multi-scale model. By means of this tri-directionally coupled system, the influence of a peripheral stenosis on tissue perfusion and oxygen supply is investigated.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Alastruey, J., Parker, K., Peiro, J., Sherwin, S.: Lumped parameter outflow models for 1-D blood flow simulations: effect on pulse waves and parameter estimation. Commun. Comput. Phys. 4, 317–336 (2008)
Andrus, J.F.: Numerical solution of systems of ordinary differential equations separated into subsystems. SIAM J. Numer. Anal. 16(4), 605–611 (1979)
Behrends, J., Bischofberger, J., et. al.: Duale Reihe Physiologie, 2nd. Auflage. Thieme Verlag, Stuttgart (2012)
Canic, S., Kim, E.: Mathematical analysis of quasilinear effects in a hyperbolic model blood flow through compliant axi-symmetric vessels. Math. Methods Appl. Sci. 26, 1161–1186 (2003)
Cattaneo, L., Zunino, P.: Computational models for fluid exchange between microcirculation and tissue interstitium. Netw. Heterog. Media 9, 135–159 (2014)
D’Angelo, C.: Multiscale modelling of metabolism and transport phenomena in living tissues. Ph.D. thesis, EPFL, Lausanne (2007)
D’Angelo, C., Quarteroni, A.: On the coupling of 1D and 3D diffusion-reaction equations. Applications to tissue perfusion problems. Math. Models Methods Appl. Sci. 18(8), 1481–1504 (2008)
Erbertseder, K.M.: A multi-scale model for describing cancer-therapeutic transport in the human lung. Ph.D. thesis, University of Stuttgart (2012)
Formaggia, L., Nobile, F., Veneziani, A., Quarteroni, A.: Multiscale modelling of the circulatory system: a preliminary analysis. Vis. Sci. 2, 75–83 (1999)
Formaggia, L., Quarteroni, A., Veneziani, A.: Cardiovascluar mathematics-modelling and simulation of the circulatory system. Springer, Italia, Milano (2009)
Gear, C., Wells, D.: Multirate linear multistep methods. BIT 24(4), 484–502 (1984)
Gottlieb, S., Shu, C.W.: Total variation diminishing Runge-Kutta schemes. Math. Comput. 67, 73–85 (1998)
Khaled, A.R.A., Vafai, K.: The role of porous media in modeling flow and heat transfer in biological tissues. Int. J. Heat Mass Transf. 46(26), 4989–5003 (2003)
Koeppl, T., Wohlmuth, B., Helmig, R.: Reduced one-dimensional modelling and numerical simulation for mass transport in fluids. Int. J. Numer. Methods Fluids 72(2), 135–156 (2013)
Koeppl, T., Schneider, M., Pohl, U., Wohlmuth, B.: The influence of an unilateral carotid artery stenosis on brain oxygenation. Med. Eng. Phys. 36(7), 905–914 (2014)
Krivodovona, L.: Limiters for high-order discontinuous Galerkin methods. J. Comput. Phys. 226, 879–896 (2007)
Kuzmin, D.: A vertex-based hierarchical slope limiter for p-adaptive discontinuous Galerkin methods. J. Comput. Appl. Math. 233, 3077–3085 (2010)
Schmidt, R., Lang, F., Heckmann, M.: Human Physiology, Second Completely, Revised Edition. Springer, Berlin, Heidelberg, New York (1989)
Sherwin, S., Franke, V., Peiro, J., Parker, K.: One-dimensional modelling of a vascular network in space-time variables. J. Eng. Math. 47, 217–250 (2003)
Stergiopulos, N., Young, D., Rogge, T.: Computer simulation of arterial flow with applications to arterial and aortic stenoses. J. Biomech. 25, 1477–1488 (1992)
Vankan, W., Huyghe, J.M., Janssen, J., Huson, A., Hacking, W., Schreiner, W.: Finite element analysis of blood perfusion through biological tissue. Int. J. Eng. Sci. 35, 375–385 (1997)
Wang, J., Parker, K.: Wave propagation in a model of the arterial circulation. J. Biomech. 37, 457–470 (2004)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Köppl, T., Helmig, R., Wohlmuth, B. (2015). A Multi-scale Model for Mass Transport in Arteries and Tissue. In: Mehl, M., Bischoff, M., Schäfer, M. (eds) Recent Trends in Computational Engineering - CE2014. Lecture Notes in Computational Science and Engineering, vol 105. Springer, Cham. https://doi.org/10.1007/978-3-319-22997-3_12
Download citation
DOI: https://doi.org/10.1007/978-3-319-22997-3_12
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-22996-6
Online ISBN: 978-3-319-22997-3
eBook Packages: Mathematics and StatisticsMathematics and Statistics (R0)