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Endocannabinoids and the Endocrine System in Health and Disease

  • Chapter
Endocannabinoids

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 231))

Abstract

Some of the earliest reports of the effects of cannabis consumption on humans were related to endocrine system changes. In this review, the effects of cannabinoids and the role of the CB1 cannabinoid receptor in the regulation of the following endocrine systems are discussed: the hypothalamic–pituitary–gonadal axis, prolactin and oxytocin, thyroid hormone and growth hormone, and the hypothalamic–pituitary–adrenal axis. Preclinical and human study results are presented.

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Abbreviations

2-AG:

2-Arachidonoylglycerol

ACTH:

Adrenocorticotropic hormone

AEA:

N-arachidonoylethanolamine

BLA:

Basolateral amygdala

CB1R:

Type 1 cannabinoid receptor

CB2R:

Type 2 cannabinoid receptor

CNS:

Central nervous system

CRH:

Corticotropin-releasing hormone

DAG:

Diacylglycerol

eCB:

Endocannabinoid

ECS:

Endocannabinoid signaling

FAAH:

Fatty acid amide hydrolase

FGR:

Fetal growth restriction

FSH:

Follicle-stimulating hormone

GABA:

Gamma-aminobutyric acid

GH:

Growth hormone

GHRH:

Growth hormone-releasing hormone

GnRH:

Gonadotropin-releasing hormone

GR:

Glucocorticoid receptor

HPA:

Hypothalamic–pituitary–adrenal

HPG:

Hypothalamic–pituitary–gonadal

HPT:

Hypothalamic–pituitary–thyroid

i.c.v.:

Intracerebroventricular

LH:

Luteinizing hormone

MGL:

Monoacylglycerol lipase

MR:

Mineralocorticoid receptor

OVX:

Ovariectomized

OXT:

Oxytocin

PLC:

Phospholipase C

PVN:

Periventricular nucleus

SON:

Supraoptic nucleus

THC:

Δ9-Tetrahydrocannabinol

TRH:

Thyrotropin-releasing hormone

TRß1:

ß1 subtype of the thyroid hormone receptor

TSH:

Thyroid-stimulating hormone

VTA:

Ventral tegmental area

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Acknowledgments

The author was supported during the writing of this review by NIH grant R01 DA26996 and the Research and Education Program, a component of the Advancing a Healthier Wisconsin endowment at the Medical College of Wisconsin.

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  1. Neuroscience Research Center and Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA

    Cecilia J. Hillard

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  1. Professor of Neuropharmacology, University of Aberdeen Institute of Medical Sciences, Aberdeen, United Kingdom

    Roger G. Pertwee

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Hillard, C.J. (2015). Endocannabinoids and the Endocrine System in Health and Disease. In: Pertwee, R. (eds) Endocannabinoids. Handbook of Experimental Pharmacology, vol 231. Springer, Cham. https://doi.org/10.1007/978-3-319-20825-1_11

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