Skip to main content

Part of the book series: Springer Series in Statistics ((SSS))

  • 7121 Accesses

Abstract

One of the great success stories of Bayesian methods in biostatistics is inference in hierarchical models. The model-based Bayesian approach allows for coherent propagation of uncertainties and borrowing of strength across submodels and more. In this chapter we discuss nonparametric Bayesian approaches in hierarchical models, including nonparametric priors on random effects distributions and extensions of such models across multiple related studies. Honest accounting for uncertainties becomes particularly important for applications to classification, when we use posterior predictive inference for a future experimental unit to estimate unknown membership in one of several subpopulations.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 119.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Bush CA, MacEachern SN (1996) A semiparametric Bayesian model for randomised block designs. Biometrika 83:275–285

    Article  MATH  Google Scholar 

  • Davidian M, Gallant A (1993) The nonlinear mixed effects model with a smooth random effects density. Biometrika 80:475–488

    Article  MATH  MathSciNet  Google Scholar 

  • Davidian M, Giltinan D (1995) Nonlinear models for repeated measurement data. Chapman and Hall, London

    Google Scholar 

  • De la Cruz R, Quintana FA, Müller P (2007) Semiparametric Bayesian classification with longitudinal markers. Appl Stat 56(2):119–137

    MATH  Google Scholar 

  • Dunson DB, Xue Y, Carin L (2008) The matrix stick-breaking process: flexible Bayes meta-analysis. J Am Stat Assoc 103(481):317–327

    Article  MATH  MathSciNet  Google Scholar 

  • Gelman A (2006) Prior distributions for variance parameters in hierarchical models. Bayesian Anal 1:515–533

    Article  MathSciNet  Google Scholar 

  • Ghosh P, Hanson T (2010) A semiparametric Bayesian approach to multivariate longitudinal data. Aust N Z J Stat 52:275–288

    Article  MathSciNet  Google Scholar 

  • Jara A, Hanson TE (2011) A class of mixtures of dependent tailfree processes. Biometrika 98:553–566

    Article  MATH  MathSciNet  Google Scholar 

  • Jara A, Hanson T, Lesaffre E (2009) Robustifying generalized linear mixed models using a new class of mixture of multivariate Polya trees. J Comput Graph Stat 18:838–860

    Article  MathSciNet  Google Scholar 

  • Jara A, Hanson TE, Quintana FA, Müller P, Rosner GL (2011) DPpackage: Bayesian semi- and nonparametric modeling in R. J Stat Softw 40(5):1–30

    Google Scholar 

  • Kleinman K, Ibrahim J (1998) A semi-parametric Bayesian approach to the random effects model. Biometrics 54:921–938

    Article  MATH  Google Scholar 

  • Kolossiatis M, Griffin J, Steel M (2013) On Bayesian nonparametric modelling of two correlated distributions. Stat Comput 23(1):1–15. doi:10.1007/s11222-011-9283-7. http://dx.doi.org/10.1007/s11222-011-9283-7

  • Lavine M (1992) Some aspects of Polya tree distributions for statistical modeling. Ann Stat 20:1222–1235

    Article  MATH  MathSciNet  Google Scholar 

  • Lavine M (1994) More aspects of Polya tree distributions for statistical modeling. Ann Stat 22:1161–1176

    Article  MATH  MathSciNet  Google Scholar 

  • Lichtman SM, Ratain MJ, Van Echo DA, Rosner G, Egorin MJ, Budman DR, Vogelzang NJ, Norton L, Schilsky RL (1993) Phase i trial of granulocyte-macrophage colony-stimulating factor plus high-dose cyclophosphamide given every 2 weeks: a cancer and leukemia group b study. J Nat Cancer Inst 85(16):1319–1326

    Article  Google Scholar 

  • Lopes HF, Muller P, Rosner GL (2003) Bayesian meta-analysis for longitudinal data models using multivariate mixture priors. Biometrics 59(1):66–75

    Article  MATH  MathSciNet  Google Scholar 

  • Malec D, Müller P (2008) A Bayesian semi-parametric model for small area estimation. In: Ghoshal S, Clarke B (eds) Festschrift in honor of J.K. Ghosh. IMS, Hayward, pp 223–236

    Google Scholar 

  • Mallet A, Mentré F, Steimer JL, Lokiec F (1988) Nonparametric maximum likelihood estimation for population pharmacokinetics, with application to cyclosporine. J Pharmacokinet Biopharm 16:311–327

    Article  Google Scholar 

  • Mengersen KL, Robert CP (1996) Testing for mixtures: a Bayesian entropic approach. In: Bayesian statistics, vol 5 (Alicante, 1994). Oxford Science Publications, Oxford University Press, New York, pp 255–276

    Google Scholar 

  • Mukhopadhyay S, Gelfand A (1997) Dirichlet process mixed generalized linear models. J Am Stat Assoc 92:633–639

    Article  MATH  MathSciNet  Google Scholar 

  • Müller P, Rosner G (1997) A Bayesian population model with hierarchical mixture priors applied to blood count data. J Am Stat Assoc 92:1279–1292

    MATH  Google Scholar 

  • Müller P, Quintana FA, Rosner G (2004) A method for combining inference across related nonparametric Bayesian models. J R Stat Soc Ser B Stat Methodol 66(3):735–749

    Article  MATH  MathSciNet  Google Scholar 

  • Müller P, Rosner GL, Iorio MD, MacEachern S (2005) A nonparametric Bayesian model for inference in related longitudinal studies. J R Stat Soc Ser C Appl Stat 54(3):611–626

    Article  MATH  Google Scholar 

  • Rodríguez A, Dunson DB, Gelfand AE (2008) The nested Dirichlet process, with discussion. J Am Stat Assoc 103:1131–1144

    Article  MATH  Google Scholar 

  • Roeder K, Wasserman L (1997) Practical Bayesian density estimation using mixtures of normals. J Am Stat Assoc 92(439):894–902

    Article  MATH  MathSciNet  Google Scholar 

  • Rosner G, Müller P (1997) Bayesian population pharmacokinetic and pharmacodynamic analyses using mixture models. J Pharmacokinet Biopharm 25:209–233

    Article  Google Scholar 

  • Schumitzky A (1993) The nonparametric maximum likelihood approach to pharmacokinetic population analysis. In: Western simulation multiconference—simulation in health care. Society for Computer Simulation, San Diego, pp 95–100

    Google Scholar 

  • Teh YW, Jordan MI, Beal MJ, Blei DM (2006) Sharing clusters among related groups: hierarchical Dirichlet processes. J Am Stat Assoc 101:1566–1581

    Article  MATH  MathSciNet  Google Scholar 

  • Wade S, Mongelluzzo S, Petrone S (2011) An enriched conjugate prior for Bayesian nonparametric inference. Bayesian Anal 6(3):359–385

    Article  MathSciNet  Google Scholar 

  • Wakefield J, Smith A, Racine-Poon A, Gelfand A (1994) Bayesian analysis of linear and nonlinear population models using the gibbs sampler. Appl Stat 43:201–221

    Article  MATH  Google Scholar 

  • Wakefield J, Aarons L, Racine-Poon A (1999) The Bayesian approach to population pharmacokinetic/pharmacodynamic modelling. In: Carlin B, Carriquiry A, Gatsonis C, Gelman A, Kass R, Verdinelli I, West M (eds) Case studies in Bayesian statistics. Springer, New York

    Google Scholar 

  • Walker S, Wakefield J (1998) Population models with a nonparametric random coefficient distribution. Sankhya Ser B 60:196–214

    MATH  MathSciNet  Google Scholar 

  • Wang Y, Taylor JM (2001) Jointly modeling longitudinal and event time data with applcation to acquired immunodeficiency syndrome. J Am Stat Assoc 96:895–903

    Article  MATH  MathSciNet  Google Scholar 

  • Wood W, Budman D, Korzun A, Cooper M, Younger J, Hart R, Moore A, Ellerton J, Norton L, Ferree C, Ballow A, Ill E, Henderson I (1994) Dose and dose intensity of adjuvant chemotherapy for stage ii, node positive breast cancer. N Engl J Med 330:1253–1259

    Article  Google Scholar 

  • Yang Y, Müller P, Rosner G (2010) Semiparametric Bayesian inference for repeated fractional measurement data. Chil J Stat 1:59–74

    MATH  MathSciNet  Google Scholar 

  • Zeger SL, Karim MR (1991) Generalized linear models with random effects: a Gibbs sampling approach. J Am Stat Assoc 86:79–86

    Article  MathSciNet  Google Scholar 

  • Zhao L, Hanson TE, Carlin BP (2009) Mixtures of Polya trees for flexible spatial frailty survival modelling. Biometrika 96(2):263–276

    Article  MATH  MathSciNet  Google Scholar 

  • Zhou H, Hanson T, Jara A, Zhang J (2015) Modelling county level breast cancer survival data using a covariate-adjusted frailty proportional hazards model. Ann Appl Stat 9:43–68

    Article  MathSciNet  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Müller, P., Quintana, F.A., Jara, A., Hanson, T. (2015). Hierarchical Models. In: Bayesian Nonparametric Data Analysis. Springer Series in Statistics. Springer, Cham. https://doi.org/10.1007/978-3-319-18968-0_7

Download citation

Publish with us

Policies and ethics