Abstract
One of the great success stories of Bayesian methods in biostatistics is inference in hierarchical models. The model-based Bayesian approach allows for coherent propagation of uncertainties and borrowing of strength across submodels and more. In this chapter we discuss nonparametric Bayesian approaches in hierarchical models, including nonparametric priors on random effects distributions and extensions of such models across multiple related studies. Honest accounting for uncertainties becomes particularly important for applications to classification, when we use posterior predictive inference for a future experimental unit to estimate unknown membership in one of several subpopulations.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bush CA, MacEachern SN (1996) A semiparametric Bayesian model for randomised block designs. Biometrika 83:275–285
Davidian M, Gallant A (1993) The nonlinear mixed effects model with a smooth random effects density. Biometrika 80:475–488
Davidian M, Giltinan D (1995) Nonlinear models for repeated measurement data. Chapman and Hall, London
De la Cruz R, Quintana FA, Müller P (2007) Semiparametric Bayesian classification with longitudinal markers. Appl Stat 56(2):119–137
Dunson DB, Xue Y, Carin L (2008) The matrix stick-breaking process: flexible Bayes meta-analysis. J Am Stat Assoc 103(481):317–327
Gelman A (2006) Prior distributions for variance parameters in hierarchical models. Bayesian Anal 1:515–533
Ghosh P, Hanson T (2010) A semiparametric Bayesian approach to multivariate longitudinal data. Aust N Z J Stat 52:275–288
Jara A, Hanson TE (2011) A class of mixtures of dependent tailfree processes. Biometrika 98:553–566
Jara A, Hanson T, Lesaffre E (2009) Robustifying generalized linear mixed models using a new class of mixture of multivariate Polya trees. J Comput Graph Stat 18:838–860
Jara A, Hanson TE, Quintana FA, Müller P, Rosner GL (2011) DPpackage: Bayesian semi- and nonparametric modeling in R. J Stat Softw 40(5):1–30
Kleinman K, Ibrahim J (1998) A semi-parametric Bayesian approach to the random effects model. Biometrics 54:921–938
Kolossiatis M, Griffin J, Steel M (2013) On Bayesian nonparametric modelling of two correlated distributions. Stat Comput 23(1):1–15. doi:10.1007/s11222-011-9283-7. http://dx.doi.org/10.1007/s11222-011-9283-7
Lavine M (1992) Some aspects of Polya tree distributions for statistical modeling. Ann Stat 20:1222–1235
Lavine M (1994) More aspects of Polya tree distributions for statistical modeling. Ann Stat 22:1161–1176
Lichtman SM, Ratain MJ, Van Echo DA, Rosner G, Egorin MJ, Budman DR, Vogelzang NJ, Norton L, Schilsky RL (1993) Phase i trial of granulocyte-macrophage colony-stimulating factor plus high-dose cyclophosphamide given every 2 weeks: a cancer and leukemia group b study. J Nat Cancer Inst 85(16):1319–1326
Lopes HF, Muller P, Rosner GL (2003) Bayesian meta-analysis for longitudinal data models using multivariate mixture priors. Biometrics 59(1):66–75
Malec D, Müller P (2008) A Bayesian semi-parametric model for small area estimation. In: Ghoshal S, Clarke B (eds) Festschrift in honor of J.K. Ghosh. IMS, Hayward, pp 223–236
Mallet A, Mentré F, Steimer JL, Lokiec F (1988) Nonparametric maximum likelihood estimation for population pharmacokinetics, with application to cyclosporine. J Pharmacokinet Biopharm 16:311–327
Mengersen KL, Robert CP (1996) Testing for mixtures: a Bayesian entropic approach. In: Bayesian statistics, vol 5 (Alicante, 1994). Oxford Science Publications, Oxford University Press, New York, pp 255–276
Mukhopadhyay S, Gelfand A (1997) Dirichlet process mixed generalized linear models. J Am Stat Assoc 92:633–639
Müller P, Rosner G (1997) A Bayesian population model with hierarchical mixture priors applied to blood count data. J Am Stat Assoc 92:1279–1292
Müller P, Quintana FA, Rosner G (2004) A method for combining inference across related nonparametric Bayesian models. J R Stat Soc Ser B Stat Methodol 66(3):735–749
Müller P, Rosner GL, Iorio MD, MacEachern S (2005) A nonparametric Bayesian model for inference in related longitudinal studies. J R Stat Soc Ser C Appl Stat 54(3):611–626
Rodríguez A, Dunson DB, Gelfand AE (2008) The nested Dirichlet process, with discussion. J Am Stat Assoc 103:1131–1144
Roeder K, Wasserman L (1997) Practical Bayesian density estimation using mixtures of normals. J Am Stat Assoc 92(439):894–902
Rosner G, Müller P (1997) Bayesian population pharmacokinetic and pharmacodynamic analyses using mixture models. J Pharmacokinet Biopharm 25:209–233
Schumitzky A (1993) The nonparametric maximum likelihood approach to pharmacokinetic population analysis. In: Western simulation multiconference—simulation in health care. Society for Computer Simulation, San Diego, pp 95–100
Teh YW, Jordan MI, Beal MJ, Blei DM (2006) Sharing clusters among related groups: hierarchical Dirichlet processes. J Am Stat Assoc 101:1566–1581
Wade S, Mongelluzzo S, Petrone S (2011) An enriched conjugate prior for Bayesian nonparametric inference. Bayesian Anal 6(3):359–385
Wakefield J, Smith A, Racine-Poon A, Gelfand A (1994) Bayesian analysis of linear and nonlinear population models using the gibbs sampler. Appl Stat 43:201–221
Wakefield J, Aarons L, Racine-Poon A (1999) The Bayesian approach to population pharmacokinetic/pharmacodynamic modelling. In: Carlin B, Carriquiry A, Gatsonis C, Gelman A, Kass R, Verdinelli I, West M (eds) Case studies in Bayesian statistics. Springer, New York
Walker S, Wakefield J (1998) Population models with a nonparametric random coefficient distribution. Sankhya Ser B 60:196–214
Wang Y, Taylor JM (2001) Jointly modeling longitudinal and event time data with applcation to acquired immunodeficiency syndrome. J Am Stat Assoc 96:895–903
Wood W, Budman D, Korzun A, Cooper M, Younger J, Hart R, Moore A, Ellerton J, Norton L, Ferree C, Ballow A, Ill E, Henderson I (1994) Dose and dose intensity of adjuvant chemotherapy for stage ii, node positive breast cancer. N Engl J Med 330:1253–1259
Yang Y, Müller P, Rosner G (2010) Semiparametric Bayesian inference for repeated fractional measurement data. Chil J Stat 1:59–74
Zeger SL, Karim MR (1991) Generalized linear models with random effects: a Gibbs sampling approach. J Am Stat Assoc 86:79–86
Zhao L, Hanson TE, Carlin BP (2009) Mixtures of Polya trees for flexible spatial frailty survival modelling. Biometrika 96(2):263–276
Zhou H, Hanson T, Jara A, Zhang J (2015) Modelling county level breast cancer survival data using a covariate-adjusted frailty proportional hazards model. Ann Appl Stat 9:43–68
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Müller, P., Quintana, F.A., Jara, A., Hanson, T. (2015). Hierarchical Models. In: Bayesian Nonparametric Data Analysis. Springer Series in Statistics. Springer, Cham. https://doi.org/10.1007/978-3-319-18968-0_7
Download citation
DOI: https://doi.org/10.1007/978-3-319-18968-0_7
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-18967-3
Online ISBN: 978-3-319-18968-0
eBook Packages: Mathematics and StatisticsMathematics and Statistics (R0)