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TRP Channels in Transduction for Responses to Odorants and Pheromones

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TRP Channels in Sensory Transduction

Abstract

Transient receptor potential cation channel, subfamily C, member 2 (TRPC2) is a TRP channel expressed by sensory neurons in the vomeronasal organ. Clearly the TRPC2 channel is critically important for transduction in the vomeronasal sensory neurons. However, it appears that TRPC2 is not the only channel that mediates chemical transduction in the VNO. In addition the transient receptor potential channel M5 (TRPM5) is expressed in approximately 5 % of the olfactory sensory neurons in the main olfactory epithelium where it plays a role in responding to intraspecific semiochemicals (chemicals involved in animal communication of the same species). Interestingly, TRPC2 is expressed in rodents but not in humans, whereas TRPM5 is expressed in the human raising the question for future work whether this TRP channel is involved in human semiochemical transduction.

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Acknowledgements

FONDECYT 1140520 (JB), DC006828 (WL), DC009269 (WL), DC04657 (DR) and DC006070 (DR).

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Authors and Affiliations

  1. Department of Cell and Developmental Biology, Neuroscience Program and Rocky Mountain Taste and Smell Center, University of Colorado, Anschutz Medical Campus, 80045, Aurora, CO, USA

    Diego Restrepo

  2. Department of Biology, Vermont Chemosensory Group, University of Vermont, 05405, Burlington, VT, USA

    Rona Delay

  3. Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD, USA

    Weihong Lin

  4. Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago, Chile

    Fabián López & Juan Bacigalupo

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  1. Diego Restrepo
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  2. Rona Delay
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  3. Weihong Lin
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  4. Fabián López
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  5. Juan Bacigalupo
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Correspondence to Diego Restrepo .

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Editors and Affiliations

  1. Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago, Chile

    Rodolfo Madrid

  2. Faculty of Science, University of Chile, Santiago, Chile

    Juan Bacigalupo

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Restrepo, D., Delay, R., Lin, W., López, F., Bacigalupo, J. (2015). TRP Channels in Transduction for Responses to Odorants and Pheromones. In: Madrid, R., Bacigalupo, J. (eds) TRP Channels in Sensory Transduction. Springer, Cham. https://doi.org/10.1007/978-3-319-18705-1_5

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