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TRP Channels in Visual Transduction

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TRP Channels in Sensory Transduction

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Abstract

The original members of the superfamily of transient receptor potential channels are the TRP and TRPL channels underlying Drosophila light transduction. Light transduction takes place in the photosensitive microvilli within the photoreceptor cells; it is initiated by photon absorption which leads ultimately to the generation of a depolarizing receptor potential caused by TRP and TRPL channel opening. Channel opening is mediated by a phospholipase C pathway where the membrane second messenger diacylglycerol appears to be the channel activator. TRP is a Ca2+ selective channel responsible for nearly 95 % of the net transduction current, whereas TRPL, a poorly-selective Ca2+ channel, accounts for the difference. The scaffolding protein INAD forms a complex with TRP and other transduction proteins, offering an extremely fast transduction mechanism. TRP and TRPL are also found in the synaptic terminals of the photoreceptors, where they play a role in presynaptic Ca2+ increments during synaptic transmission.

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Acknowledgements

FONDECYT 1140520 (JB), CONICYT Graduate Fellowship 22110957 (YM).

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Authors and Affiliations

  1. Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago, Chile

    Juan Bacigalupo, Ricardo Delgado & Yorka Muñoz

  2. Institute of Neuroscience, University of Oregon, Eugene, OR, USA

    Peter O’Day

Authors
  1. Juan Bacigalupo
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  2. Ricardo Delgado
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  3. Yorka Muñoz
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  4. Peter O’Day
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Corresponding author

Correspondence to Juan Bacigalupo .

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Editors and Affiliations

  1. Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago, Chile

    Rodolfo Madrid

  2. Faculty of Science, University of Chile, Santiago, Chile

    Juan Bacigalupo

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Bacigalupo, J., Delgado, R., Muñoz, Y., O’Day, P. (2015). TRP Channels in Visual Transduction. In: Madrid, R., Bacigalupo, J. (eds) TRP Channels in Sensory Transduction. Springer, Cham. https://doi.org/10.1007/978-3-319-18705-1_4

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