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Humoral Mediators of Remote Ischemic Conditioning: Important Role of eNOS/NO/Nitrite

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Brain Edema XVI

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 121))

Abstract

Remote ischemic conditioning (RIC) is a powerful cardioprotectant and neuroprotectant. The mechanism of protection likely involves circulating, blood-borne mediators that transmit the signal from the periphery to the brain. The neuroprotective effect of RIC may be partially related to improvements in cerebral blood flow (CBF). Nitrite is a key circulating mediator of RIC and may be a mediator of increased CBF and also mediate cytoprotection through its effects on nitrosylation of mitochondrial proteins such as complex I. Measuring plasma nitrite may serve as an important blood biomarker, and measuring CBF by techniques such as MRI arterial spin labeling (ASL) may be an ideal surrogate imaging biomarker in clinical trials of RIC.

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Acknowledgments

The authors would like to acknowledge Colby Polonsky, medical illustrator, Georgia Regent’s University for Fig. 1. This work is supported by NIH-NINDS R21 NS081143.

Conflict of Interest

The authors have no conflicts of interest to report.

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Authors and Affiliations

  1. Department of Neurology, Medical College of Georgia, Georgia Regent’s University, Augusta, GA, 30912, USA

    David C. Hess MD & Mohammad B. Khan PhD

  2. Department of Medical Laboratory, Imaging and Radiological Sciences College of Allied Health Sciences, Georgia Regent’s University, Augusta, GA, 30912, USA

    Mohammad Nasrul Hoda PhD

Authors
  1. David C. Hess MD
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  3. Mohammad B. Khan PhD
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Corresponding author

Correspondence to David C. Hess MD .

Editor information

Editors and Affiliations

  1. Department of Anesthesiology, Loma Linda University School of Medicine, Loma Linda, California, USA

    Richard L. Applegate

  2. Department of Neurosurgery, Soochow University The First Affiliated Hospital, Suzhou, Jiangsu, China

    Gang Chen

  3. Department of Neurosurgery, Third Military Medical University Southwest Hospital, Chongqing, China

    Hua Feng

  4. Dept.of Anesthesiology, Physiology and Neurosurgery, Loma Linda University School of Medicine, Loma Linda, California, USA

    John H. Zhang

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Hess, D.C., Hoda, M.N., Khan, M.B. (2016). Humoral Mediators of Remote Ischemic Conditioning: Important Role of eNOS/NO/Nitrite. In: Applegate, R., Chen, G., Feng, H., Zhang, J. (eds) Brain Edema XVI. Acta Neurochirurgica Supplement, vol 121. Springer, Cham. https://doi.org/10.1007/978-3-319-18497-5_8

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  • DOI: https://doi.org/10.1007/978-3-319-18497-5_8

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-18496-8

  • Online ISBN: 978-3-319-18497-5

  • eBook Packages: MedicineMedicine (R0)

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