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Role of Circulating Immune Cells in Stroke and Preconditioning-Induced Protection

  • Chapter
Brain Edema XVI

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 121))

Abstract

Stroke activates an inflammatory response that results in the infiltration of peripheral immune cells into the ischemic area, contributing to exacerbation of tissue damage. However, evidence indicates that inflammatory cell infiltration can also promote neuroprotection through regulatory immune cells that mitigate injury. These immune regulatory cells may also be important mediators of neuroprotection associated with preconditioning, a phenomenon whereby small exposure to a potential harmful stimulus is able to induce protection against a subsequent ischemic event. The elucidation of mechanisms that allow these immune cells to confer neuroprotection is critical to developing new therapeutic strategies against acute stroke. In the present review, we discuss the dual role of peripheral immune cells in stroke-related brain injury and neuroprotection. Furthermore, we report new data from our laboratory that supports the important role of peripheral cells and their interaction with the brain endothelium for the establishment of the protective phenotype in preconditioning.

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Conflict of Interest Statement

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA

    Raffaella Gesuete & Susan L. Stevens

  2. Department of Molecular Microbiology and Immunology, L220, Oregon Health and Science University, 3181 Sam Jackson Park Road, Portland, OR, 97239, USA

    Mary P. Stenzel-Poore

Authors
  1. Raffaella Gesuete
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  2. Susan L. Stevens
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  3. Mary P. Stenzel-Poore
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Corresponding author

Correspondence to Mary P. Stenzel-Poore .

Editor information

Editors and Affiliations

  1. Department of Anesthesiology, Loma Linda University School of Medicine, Loma Linda, California, USA

    Richard L. Applegate

  2. Department of Neurosurgery, Soochow University The First Affiliated Hospital, Suzhou, Jiangsu, China

    Gang Chen

  3. Department of Neurosurgery, Third Military Medical University Southwest Hospital, Chongqing, China

    Hua Feng

  4. Dept.of Anesthesiology, Physiology and Neurosurgery, Loma Linda University School of Medicine, Loma Linda, California, USA

    John H. Zhang

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Gesuete, R., Stevens, S.L., Stenzel-Poore, M.P. (2016). Role of Circulating Immune Cells in Stroke and Preconditioning-Induced Protection. In: Applegate, R., Chen, G., Feng, H., Zhang, J. (eds) Brain Edema XVI. Acta Neurochirurgica Supplement, vol 121. Springer, Cham. https://doi.org/10.1007/978-3-319-18497-5_7

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  • DOI: https://doi.org/10.1007/978-3-319-18497-5_7

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-18496-8

  • Online ISBN: 978-3-319-18497-5

  • eBook Packages: MedicineMedicine (R0)

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