Abstract
Social cognition (SC) impairment can contribute to everyday life difficulties in multiple sclerosis (MS). Studies tend to show that facial emotion recognition and generally emotion processing are impaired in MS. Only one study failed to show impairment in facial emotion recognition, but MS patients had a slow emotional processing. Deficits in cognitive and affective inferences about mental states of others have also been demonstrated in various heterogeneous groups and with various methodologies used to assess theory of mind. The relationship of cognitive impairment with SC impairment is still discussed. Results from functional imaging studies in MS suggested that there is brain dysfunction in areas previously demonstrated as key regions for emotional processing (ventrolateral prefrontal cortex, left anterior insula, limbic area). Results concerning morphological MRI studies, brain lesion volumes, and cortical thinning are still very preliminary, but one study suggested that cortical thinning in some regions of the brain correlated with emotion recognition test and mentalizing tasks. Results concerning correlation of SC with brain lesions are conflicting. Morphological and functional MRI studies are still limited in this area, and more studies are needed for a better understanding of these impairments.
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Abbreviations
- MS:
-
multiple sclerosis
- ToM:
-
theory of mind
- HCS:
-
healthy control subjects
- fMRI:
-
functional MRI
- VLPLC:
-
ventrolateral prefrontal cortex
References
Filley CM. White matter and behavioral neurology. Ann N Y Acad Sci. 2005;1064:162–83.
Krause M, Wendt J, Dressel A, Berneiser J, Kessler C, Hamm AO, et al. Prefrontal function associated with impaired emotion recognition in patients with multiple sclerosis. Behav Brain Res. 2009;205:280–5.
Passamonti L, Cerasa A, Liguori M, Gioia MC, Valentino P, Nistico R, et al. Neurobiological mechanisms underlying emotional processing in relapsing-remitting multiple sclerosis. Brain. 2009;132:3380–91.
Jehna M, Langkammer C, Wallner-Blazek M, Neuper C, Loitfelder M, Ropele S, et al. Cognitively preserved MS patients demonstrate functional differences in processing neutral and emotional faces. Brain Imaging Behav. 2011;5:241–51.
Jehna M, Neuper C, Petrovic K, Wallner-Blazek M, Schmidt R, Fuchs S, et al. An exploratory study on emotion recognition in patients with a clinically isolated syndrome and multiple sclerosis. Clin Neurol Neurosurg. 2010;112:482–4.
Henry JD, Phillips LH, Beatty WW, Mcdonald S, Longley WA, Joscelyne A, et al. Evidence for deficits in facial affect recognition and theory of mind in multiple sclerosis. J Int Neuropsychol Soc. 2009;15:277.
Henry A, Tourbah A, Chaunu M-P, Rumbach L, Montreuil M, Bakchine S. Social cognition impairments in relapsing-remitting multiple sclerosis. J Int Neuropsychol Soc. 2011;17:1122–31.
Berneiser J, Wendt J, Grothe M, Kessler C, Hamm AO, Dressel A. Impaired recognition of emotional facial expressions in patients with multiple sclerosis. Mult Scler Relat Disord. 2014;3:482–8.
Phillips LH, Henry JD, Scott C, Summers F, Whyte M, Cook M. Specific impairments of emotion perception in multiple sclerosis. Neuropsychology. 2011;25:131–6.
Banati M, Sandor J, Mike A, Illes E, Bors L, Feldmann A, et al. Social cognition and theory of mind in patients with relapsing-remitting multiple sclerosis. Eur J Neurol. 2010;17:426–33.
Beatty WW, Goodkin DE, Weir WS, Staton RD, Monson N, Beatty PA. Affective judgments by patients with Parkinson’s disease or chronic progressive multiple sclerosis. Bull Psychon Soc. 1989;27:361–4.
Prochnow D, Donell J, Schäfer R, Jörgens S, Hartung HP, Franz M, et al. Alexithymia and impaired facial affect recognition in multiple sclerosis. J Neurol. 2011;258:1683–8.
Ekman P, Friesen W. Pictures of facial affect. Palo Alto, CA: Consulting Psychologist Press; 1976.
Baron-Cohen S, Wheelwright S. Jolliffe, Therese. Is there a “language of the eyes”? Evidence from normal adults, and adults with autism or Asperger syndrome. Vis Cogn. 1997;4:311–31.
Bowers D, Blonder LX, Heilman KM. The Florida affect battery, manual (revised). Gainesville: Center for Neuropsychological Studies, University of Florida; 2001.
Beatty WW, Orbelo DM, Sorocco KH, Ross ED. Comprehension of affective prosody in multiple sclerosis. Mult Scler. 2003;9:148–53.
Kraemer M, Herold M, Uekermann J, Kis B, Daum I, Wiltfang J, Berlit P, Diehl RR, Abdel-Hamid M. Perception of affective prosody in patients at an early stage of relapsing-remitting multiple sclerosis. J Neuropsychol. 2013;1:91–106.
Kraemer M, Herold M, Uekermann J, Kis B, Wiltfang J, Daum I, et al. Theory of mind and empathy in patients at an early stage of relapsing remitting multiple sclerosis. Clin Neurol Neurosurg. 2012;115:1016–22.
Ouellet J, Scherzer PB, Rouleau I, Métras P, Bertrand-Gauvin C, Djerroud N, et al. Assessment of social cognition in patients with multiple sclerosis. J Int Neuropsychol Soc. 2010;16:287.
Benedict RH, Priore RL, Miller C, Munschauer F, Jacobs L. Personality disorder in multiple sclerosis correlates with cognitive impairment. J Neuropsychiatry Clin Neurosci. 2001;13:70–6.
Roca M, Manes F, Gleichgerrcht E, Ibanez A, Gonzalez de Toledo ME, Marenco V, Bruno D, Torralva T, Sinay V. Cognitive but not affective theory of mind deficits in mild relapsing-remitting multiple sclerosis. Cogn Behav Neurol. 2014;1:25–30.
Dziobek I, Fleck S, Kalbe E, Rogers K, Hassenstab J, Brand M, et al. Introducing MASC: a movie for the assessment of social cognition. J Autism Dev Disord. 2006;36:623–36.
Pottgen J, Dziobek I, Reh S, Heesen C, Gold SM. Impaired social cognition in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2013;84:523–8.
Langer-Gould A, Zhang JL, Chung J, et al. Incidence of acquired CNS demyelinating syndromes in a multiethnic cohort of children. Neurology. 2011;77:1143–8.
Charvet L, Cleary R, Vazquez K, Belman A, Krupp L, on behalf of the US Network for Pediatric MS. Social cognition in pediatric-onset multiple sclerosis (MS). Mult Scler J. 2014;82.
Bechara A, Damasio AR, Damasio H, Anderson SW. Insensitivity to future consequences following damage to human pre- frontal cortex. Cognition. 1994;50:7–15.
Kleeberg J, Bruggimann L, Annoni J-M, van Melle G, Bogousslavsky J, Schluep M. Altered decision-making in multiple sclerosis: a sign of impaired emotional reactivity? Ann Neurol. 2004;56:787–95.
Sumowski JF, Wylie GR, Deluca J, Chiaravalloti N. Intellectual enrichment is linked to cerebral efficiency in multiple sclerosis: functional magnetic resonance imaging evidence for cognitive reserve. Brain. 2009;133(2):362–74.
Mike A, Strammer E, Aradi M, Orsi G, Perlaki G, Hajnal A, et al. Disconnection mechanism and regional cortical atrophy contribute to impaired processing of facial expressions and theory of mind in multiple sclerosis: a structural MRI study. PLoS ONE. 2013;8, e82422.
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Dulau, C. (2015). Social Cognition and Multiple Sclerosis. In: Brochet, B. (eds) Neuropsychiatric Symptoms of Inflammatory Demyelinating Diseases. Neuropsychiatric Symptoms of Neurological Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-18464-7_15
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DOI: https://doi.org/10.1007/978-3-319-18464-7_15
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