Abstract
Primary angle closure glaucoma (PACG) represents a significant burden to glaucoma services throughout the world, accounting for 26 % of all people with glaucoma. Furthermore, it is estimated that angle closure glaucoma accounts for 50 % of total glaucoma blindness. Whilst traditional management involves the use of topical intraocular pressure (IOP) lowering medications and laser treatment in the form of iridotomy or iridoplasty, in many cases this is suboptimal—glaucoma continues to progress and lead to irreversible sight loss.
Lens extraction is increasingly being recognized as an effective treatment option for PACG. Evidence from anterior segment imaging, such as anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM) suggests that mechanical factors such as lens vault and thickness likely exacerbate angle crowding. Lens extraction addresses these factors, hypothetically permitting improved aqueous access to the trabecular meshwork. The publication of cohort studies and randomized control trials have provided a strong foundation for ophthalmic surgeons to offer lens extraction surgery as a viable treatment option for PACG, recognizing better IOP control and the reduced need for IOP lowering medications. Furthermore, simultaneous additional procedures at the time of lens extraction, such as goniosynechialysis (GSL) and trabeculectomy, have been advocated to improve IOP control further.
This chapter begins with a summary of the theoretical role of the lens in ACG. The argument for considering lens extraction in PACG is then described, along with aspects of preoperative counselling. Surgical techniques for the management of eyes with coexisting PACG and cataract are expressed from our practice, which have helped to reduce complications and ensure optimal outcomes for patients.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90:262–7.
Nogpiur M, Ku JY, Aung T. Angle closure glaucoma: a mechanistic review. Curr Opin Ophthalmol. 2011;22(2):96–101.
Wang B, Sakata LM, Friedman DS. Quantitative iris parameters and association with narrow angles. Ophthalmology. 2010;118:474–9.
Tsai A, Wong TT, Perera SA. The utility of anterior segment imaging in an atypical case of angle closure. In: Proceedings of Singapore Health Care, 2012. vol 21, p. 1.
Tomlinson A, Leighton DA. Ocular dimensions in the heredity of angle closure glaucoma. Br J Ophthalmol. 1973;57:475–86.
Nongpiur ME, He MG, Amerasinghe N, et al. Lens vault, thickness and position in chinese subjects with angle closure. Ophthalmology. 2011;118:474–9.
Matsumura M, Mizoguchi T, Kuroda S, et al. Intraocular pressure decrease after phacoemulsification-aspiration + intraocular lens implantation in primary open angle glaucoma eyes. Nihon Ganka Gakkai Zasshi. 1996;100(11):885–9.
Wishart PK, Atkinson PL. Extracapsular cataract extraction and posterior chamber lens implantation in patients with primary chronic angle-closure glaucoma: effect on intraocular pressure control. Eye (Lond). 1989;3(Pt 6):706–12.
Gunning FP, Greve EL. Lens extraction for uncontrolled angle-closure glaucoma: long-term follow-up. J Cataract Refract Surg. 1998;24(10):1347–56.
Hayashi K, Hayashi H, Nakao F, et al. Effect of cataract surgery on intraocular pressure control in glaucoma patients. J Cataract Refract Surg. 2001;27(11):1779–86.
Imaizumi M, Takaki Y, Yamashita H. Phacoemulsification and intraocular lens implantation for acute angle closure not treated or previously treated by laser iridotomy. J Cataract Refract Surg. 2006;32(1):85–90.
Chan JCI, Lai JS, Tham CC. Comparison of postoperative refractive outcome in phacotrabeculectomy and phacoemulsification with posterior chamber intraocular lens implantation. J Glaucoma. 2006;15(1):26–9.
Husain R, Gazzard G, Aung T, et al. Initial management of acute primary angle closure: a randomized trial comparing phacoemulsification with laser peripheral iridotomy. Ophthalmology. 2012;119(11):2274–81.
Lam DS, Leung DY, Tham CC, et al. Randomized trial of early phacoemulsification versus peripheral iridotomy to prevent intraocular pressure rise after acute primary angle closure. Ophthalmology. 2008;115(7):1134–40.
Alsagoff Z, Aung T, Ang LP, et al. Long-term clinical course of primary angle closure glaucoma in an Asian population. Ophthalmology. 2000;1074:2300–4.
Lai JS, Tham CC, Chan JC. The clinical outcomes of cataract extraction by phacoemulsification in eyes with primary angle closure glaucoma. J Glaucoma. 2006;15(1):47–52.
Huang G, Gonzalez E, Lee R, et al. Association of biometric factors with anterior chamber angle widening and intraocular pressure reduction after uneventful phacoemulsification for cataract. J Cataract Refract Surg. 2012;38(1):108–16.
Tham CC, Kwong YY, Leung DY, et al. Phacoemulsification versus combined phacotrabeculectomy in medically uncontrolled chronic angle closure glaucoma with cataracts. Ophthalmology. 2009;116(4):725–31.
Tham CC, Kwong YY, Leung DY, et al. Phacoemulsification versus combined phacotrabeculectomy in medically controlled chronic angle closure glaucoma with cataracts. Ophthalmology. 2008;115:2167–73.
Colin J, El Kelbir S, Eydoux E, et al. Assessment of patient satisfaction with outcomes and ophthalmic care for cataract surgery. J Cataract Refract Surg. 2010;36(8):1373–9.
Lundström M, Stenevi U, Thorburn W. Quality of life after first- and second-eye cataract surgery: five-year data collected by the Swedish National Cataract Register. J Cataract Refract Surg. 2001;27(10):1553–9.
Nolan WP, Foster PJ, Devereux JG, et al. YAG laser iridotomy treatment for primary angle closure in East Asian eyes. Br J Ophthalmol. 2000;84:1255–9.
Harasymowycz PJ, Papamatheakis DG, Ahmed I, et al. Phacoemulsification and goniosynechiolysis in the management of unresponsive primary angle closure. J Glaucoma. 2005;14:186–9.
Campbell DG, Vela A. Modern goniosynechialysis for the treatment of synechial angle-closure glaucoma. Ophthalmology. 1984;91:1052–60.
Yu J, Sun M, Wei Y, et al. The timing of goniosynechialysis in treatment of primary angle-closure glaucoma combined with cataract. Mol Vis. 2012;18:1074–82.
Varma D, Baylis O, Wride N, et al. Viscogonioplasty: an effective procedure for lowering intraocular pressure in primary angle closure glaucoma. Eye (Lond). 2007;21:472–5.
Razeghinejad MR. Combined phacoemulsification and viscogoniosynechiolysis in patients with refractory acute-angle closure glaucoma. J Cataract Refract Surg. 2008;34:827–30.
Roberts TV, Francis IC, Lertusumitkul S, et al. Primary phacoemulsification for uncontrolled angle-closure glaucoma. J Cataract Refract Surg. 2000;26:1012–6.
Jacobi PC, Deitlein TS, Luke C, et al. Primary phacoemulsification and lens implantation for acute angle closure glaucoma. Ophthalmology. 2002;109(9):1597–603.
Lim S, Husain R, Gazzard G, et al. Cataract progression after prophylactic laser iridotomy: potential implications for the prevention of glaucoma blindness. Ophthalmology. 2005;112:1355–9.
Zare M, Javadi M, Einollahi B, et al. Risk factors for posterior capsule rupture and vitreous loss during phacoemulsification. J Ophthalmic Vis Res. 2009;4(4):208–12.
Johnston RL, Taylor H, Smith R, et al. The Cataract National Dataset electronic multi-centre audit of 55,567 operations: variation in posterior capsule rupture rates between surgeons. Eye (Lond). 2010;24(5):888–93.
Barry P, Cordoves L, Gardner S. ESCRS treatment and prevention of endophthalmitis. European Society of Cataract and Refractive surgeons, Dublin, Ireland, 2013.
Yong KL, Gong T, Nongpiur ME, et al. Myopia in asian subjects with primary angle closure: implications for glaucoma trends in East Asia. Ophthalmology. 2014;121(8):1566–71.
Acknowledgements
Financial disclosures: Nil.
Statement of informed consent: All imaging was recorded following informed consent from patients involved.
Statement on Conflict of interest: Sameer Trikha, Shamira Perera, Rahat Husain, and Tin Aung declare that they have no conflict of interest.
Ethical statement: No animal or human studies were carried out by the authors for this article. Furthermore, informed Consent and Animal Studies disclosures are not applicable to this review.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Trikha, S., Perera, S.A., Husain, R., Aung, T. (2015). Lens Extraction in Angle Closure Glaucoma. In: Aref, A., Varma, R. (eds) Advanced Glaucoma Surgery. Essentials in Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-319-18060-1_4
Download citation
DOI: https://doi.org/10.1007/978-3-319-18060-1_4
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-18059-5
Online ISBN: 978-3-319-18060-1
eBook Packages: MedicineMedicine (R0)