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Nanosystems for Immunotherapeutic Drug Delivery

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Biomaterials in Regenerative Medicine and the Immune System

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Abstract

Advances in engineered nanoformulations for immunotherapeutic drug delivery have accompanied the rapidly growing interest in clinical immunotherapy. Several material systems have been developed that confer improved efficacy by overcoming delivery barriers detrimental to drug bioactivity. Notable examples include strategies that prolong drug circulation times and enhance the delivery of immunotherapeutic drugs to lymphoid tissues enriched in immune cells important in the initiation and regulation of immune response. The utility of material nanoformulations to facilitate co-delivery of multiple drugs with synergistic activity has also been demonstrated, as has the potential for drug delivery and immunotherapeutic activity to be enhanced via receptor-mediated targeting. Important innovations have furthermore led to the development of triggered drug release mechanisms that increase the control of drug bioactivity within targeted subcellular compartments and/or tissues. This chapter details how materials engineering, formulation design, and delivery schemes have improved immunological outcomes in a variety of therapeutic applications.

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Abbreviations

Alum:

Aluminum hydroxide gel

Da:

Dalton

DTSSP:

3,3′-dithiobis(sulfosuccinimidylpropionate)

NIR:

Near infrared

nm:

Nanometer

OVA:

Chicken ovalbumin

PAM:

Tri-palmitoyl-S-glyceryl cysteine lipopeptide with a pentapeptide SKKKK

PEG:

Poly(ethylene glycol)

PLGA:

Poly(lactic-co-glycolic acid)

SB:

Transforming growth factor-β inhibitor SB505124

TGF-β:

Transforming growth factor-β

TLR:

Toll-like receptor

TRX:

3,5-didodecyloxybenzamidine

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Author information

Authors and Affiliations

  1. School of Materials Science and Engineering, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA, USA

    Alex Schudel

  2. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 315 Ferst Drive NW, Atlanta, GA, USA

    Michael C. Bellavia

  3. George W. Woodruff School of Mechanical Engineering, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA, USA

    Susan N. Thomas

Authors
  1. Alex Schudel
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  2. Michael C. Bellavia
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  3. Susan N. Thomas
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Corresponding author

Correspondence to Susan N. Thomas .

Editor information

Editors and Affiliations

  1. Albert Einstein College of Medicine, Bronx, New York, USA

    Laura Santambrogio

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© 2015 Springer International Publishing Switzerland

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Schudel, A., Bellavia, M., Thomas, S. (2015). Nanosystems for Immunotherapeutic Drug Delivery. In: Santambrogio, L. (eds) Biomaterials in Regenerative Medicine and the Immune System. Springer, Cham. https://doi.org/10.1007/978-3-319-18045-8_9

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