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Image-Guided Tumor Ablative Therapies

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Demystifying Interventional Radiology

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Abstract

The increased use of percutaneous methods for the local management of malignancy has led to a larger role for interventional radiologists within the oncology multidisciplinary team. In particular, image-guided tumor ablation has become a more common treatment for patients who are nonsurgical candidates in the management of pulmonary, hepatic, renal, and osteoid lesions. Image-guided tumor ablation is a form of minimally invasive treatment that uses chemical or thermal methods to destroy tumor cells. Presented here is a brief summary of multiple types of non-thermal and thermal ablative therapies including chemical ablation, radiofrequency ablation, microwave ablation, cryoablation, and irreversible electroporation. These techniques are currently being used or are emerging in the field of interventional oncology. Their indications, device properties, limitations, indications, and outcomes are presented here.

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References

  1. Hickey R, Vouche M, Sze DY, et al. Cancer concepts and principles: primer for the interventional oncologist – Part II. J Vasc Interv Radiol. 2013;24:1167–88.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Ahmed M, Brace CL, Lee Jr FT, Goldberg SN. Principles of and advances in percutaneous ablation. Radiology. 2011;258(2):351–69.

    Article  PubMed  Google Scholar 

  3. Lin SM, Lin CJ, Lin CC, Hsu CW, Chen YC. Randomised control trial comparing percutaneous radiofrequency thermal ablation, percutaneous ethanol injection, and percutaneous acetic acid injection to treat hepatocellular carcinoma of 3 cm or less. Gut. 2005;54(8):1151–6.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  4. Smith KA, Kim HS. Interventional radiology and image-guided medicine: interventional oncology. Semin Oncol. 2011;38(1):151–62.

    Article  PubMed  Google Scholar 

  5. Monchik JM, Donatini G, Iannuccilli J, Dupuy DE. Radiofrequency ablation and percutaneous ethanol injection treatment for recurrent local and distant well-differentiated thyroid carcinoma. Ann Surg. 2006;244(2):296–304.

    Article  PubMed Central  PubMed  Google Scholar 

  6. Fukumoto K, Kojima T, Tomonari H, Kontani K, Murai S, Tsujimoto F. Ethanol injection sclerotherapy for Baker’s cyst, thyroglossal duct cyst, and branchial cleft cyst. Ann Plast Surg. 1994;33(6):615–9.

    Article  CAS  PubMed  Google Scholar 

  7. Philips P, Hays D, Martin RCG. Irreversible electroporation ablation (IRE) of unresectable soft tissue tumors: learning curve evaluation in the first 150 patients treated. PLoS ONE. 2013;8(11):1–9.

    Google Scholar 

  8. Saldanha DF, Khiatani VL, Carrillo TC, et al. Current tumor ablation technologies: basic science and device review. Semin Intervent Radiol. 2010;27(3):247–54.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Lee EW, Thai S, Kee ST. Irreversible electroporation: a novel image-guided cancer therapy. Gut Liver. 2010;4 Suppl 1:S99–104.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Kunzli BM, Abitabile P, Maurer CA. Radiofrequency ablation of liver tumors: actual limitations and potential solutions in the future. World J Hepatol. 2011;3(1):8–14.

    PubMed Central  PubMed  Google Scholar 

  11. Gervais DA, McGovern FJ, Arellano RS, McDougal WS, Mueller PR. Radiofrequency ablation of renal cell carcinoma: part I, indications, results, and role in patient management over a 6-year period and ablation of 100 tumors. AJR Am J Roentgenol. 2005;185:64–71.

    Article  PubMed  Google Scholar 

  12. Crocetti L, de Baere T, Lencioni R. Quality improvement guidelines for radiofrequency ablation of liver tumors. Cardiovasc Intervent Radiol. 2010;33:11–7.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Kwan KG, Matsumoto ED. Radiofrequency ablation and cryoablation of renal tumors. Curr Oncol. 2007;14(1):34–8.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. Zhu JC, Yan TD, Morris DL. A systematic review of radiofrequency ablation for lung tumors. Ann Surg Oncol. 2008;15(6):1765–74.

    Article  PubMed  Google Scholar 

  15. Kurup AN, Callstrom MR. Image-guided percutaneous ablation of bone and soft-tissue tumors. Semin Intervent Radiol. 2010;27(3):276–84.

    Article  PubMed Central  PubMed  Google Scholar 

  16. Goetz MP, Callstrom MR, Charboneau JW, et al. Percutaneous image-guided radiofrequency ablation of painful metastases involving bone: a multicenter study. J Clin Oncol. 2004;22(3):300–6.

    PubMed  Google Scholar 

  17. Papathanassiou ZG, Megas P, Petsas T, Papachristou DJ, Nilas J, Siablis D. Osteoid osteoma: diagnosis and treatment. Orthopedics. 2008;31(11):1118.

    Article  PubMed  Google Scholar 

  18. Tam A, Ahrar K. Palliative interventions for pain in cancer patients. Semin Intervent Radiol. 2007;24(4):419–29.

    Article  PubMed Central  PubMed  Google Scholar 

  19. Modabber M, Martin J, Athreya S. Thermal versus impedance-based ablation of renal cell carcinoma: a meta-analysis. Cardiovasc Intervent Radiol. 2014;37:176–85.

    Article  PubMed  Google Scholar 

  20. Sheu YR, Hong K. Percutaneous lung tumor ablation. Tech Vasc Interv Radiol. 2013;16(4):239–52.

    Article  Google Scholar 

  21. Lubner MG, Brace CL, Hinshaw JL, Lee Jr FT. Microwave tumor ablation: mechanism of action, clinical results and devices. J Vasc Interv Radiol. 2010;21(8 Suppl):S192–203.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Liang P, Yu J, Lu MD, et al. Practice guidelines for ultrasound-guided percutaneous microwave ablation for hepatic malignancy. World J Gastroenterol. 2013;19(33):5430–8.

    Article  PubMed Central  PubMed  Google Scholar 

  23. Martin RC, Scoggins CR, McMasters KM. Safety and efficacy of microwave ablation of hepatic tumors: a prospective review of a 5-year experience. Ann Surg Oncol. 2010;17(1):171–8.

    Article  PubMed  Google Scholar 

  24. Castle SM, Salas N, Leveillee RJ. Initial experience using microwave ablation therapy for renal tumor treatment: 18-month follow-up. Urology. 2011;77(4):792–7.

    Article  PubMed  Google Scholar 

  25. Lu Q, Cao W, Huang L, et al. CT-guided percutaneous microwave ablation of pulmonary malignancies: results in 69 cases. World J Surg Oncol. 2012;10:80.

    Article  PubMed Central  PubMed  Google Scholar 

  26. Yu J, Liang P, Yu XL, et al. US-guided percutaneous microwave ablation versus open radical nephrectomy for small renal cell carcinoma: intermediate-term results. Radiology. 2014;270(3):880–7.

    Article  PubMed  Google Scholar 

  27. Martin J, Athreya S. Meta-analysis of cryoablation versus microwave ablation for small renal masses: is there a difference in outcome? Diagn Interv Radiol. 2013;19:501–7.

    PubMed  Google Scholar 

  28. Yamauchi Y, Izumi Y, Kawamura M, et al. Percutaneous cryoablation of pulmonary metastases from colorectal cancer. PLoS ONE. 2011;6(11):e27086.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Michael G. DeGroote School of Medicine, McMaster University, 1280 Main Street West, Hamilton, L8S 4K1, ON, Canada

    Lazar Milovanovic BASc, MD Candidate

Authors
  1. Lazar Milovanovic BASc, MD Candidate
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Correspondence to Lazar Milovanovic BASc, MD Candidate .

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Editors and Affiliations

  1. Associate Professor, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

    Sriharsha Athreya

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© 2016 Springer International Publishing Switzerland

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Milovanovic, L. (2016). Image-Guided Tumor Ablative Therapies. In: Athreya, S. (eds) Demystifying Interventional Radiology. Springer, Cham. https://doi.org/10.1007/978-3-319-17238-5_10

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  • DOI: https://doi.org/10.1007/978-3-319-17238-5_10

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-17237-8

  • Online ISBN: 978-3-319-17238-5

  • eBook Packages: MedicineMedicine (R0)

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