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Primary Cutaneous Follicle Center Lymphoma

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Atlas of Cutaneous Lymphomas

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Abstract

Primary cutaneous follicle center lymphoma (pcFCL) is an indolent B-cell lymphoma with a remarkably good prognosis. This neoplasm of mature germinal center B cells constitutes 60 % of all primary cutaneous B-cell lymphomas and 9–11 % of all cutaneous lymphomas [1, 2]. It also includes 5 % of all follicular lymphomas, nodal and extranodal [3]. It typically presents with firm, erythematous to violaceous papules, plaques, and tumors on the scalp, trunk, and upper extremities. When it occurs on the back, it has been referred to in the past as Crosti lymphoma or reticulohistiocytoma of the dorsum [1, 4]. Differentiation of pcFCL from systemic follicle center lymphomas is critical, given the substantially worse prognosis of systemic follicle center lymphomas. This chapter addresses the clinical presentation, prognosis, treatment, histopathology, immunophenotype, and differential diagnosis of pcFCL. It closes with two clinical cases, including clinical images and histopathology.

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Author information

Authors and Affiliations

  1. Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, USA

    Amrita Goyal M.D.

  2. Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Joi B. Carter M.D.

  3. Comprehensive Cutaneous Lymphoma Program, Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, USA

    Jeffrey A. Barnes M.D., Ph.D.

  4. Dermatopathology Service, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Lyn McDivitt Duncan M.D.

Authors
  1. Amrita Goyal M.D.
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  2. Joi B. Carter M.D.
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  3. Jeffrey A. Barnes M.D., Ph.D.
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  4. Lyn McDivitt Duncan M.D.
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Correspondence to Lyn McDivitt Duncan M.D. .

Editor information

Editors and Affiliations

  1. Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA

    Joi B. Carter

  2. Division of Health Sciences and Technology, Harvard Medical School, Boston, Massachusetts, USA

    Amrita Goyal

  3. Dermatopathology Service, Massachusetts General Hospital, Boston, Massachusetts, USA

    Lyn McDivitt Duncan

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© 2015 Springer International Publishing Switzerland

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Goyal, A., Carter, J.B., Barnes, J.A., Duncan, L.M. (2015). Primary Cutaneous Follicle Center Lymphoma. In: Carter, J., Goyal, A., McDivitt Duncan, L. (eds) Atlas of Cutaneous Lymphomas. Springer, Cham. https://doi.org/10.1007/978-3-319-17217-0_17

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  • DOI: https://doi.org/10.1007/978-3-319-17217-0_17

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-17216-3

  • Online ISBN: 978-3-319-17217-0

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