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Primary Cutaneous Gamma-Delta T-Cell Lymphoma

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Atlas of Cutaneous Lymphomas

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Abstract

Primary cutaneous gamma-delta T-cell lymphoma (pcGDTCL) is a rare but lethal lymphoma. Patients typically develop ulcerated cutaneous nodules, metastases to other extranodal sites, B (systemic) symptoms, and hemophagocytic syndrome. It is highly treatment-resistant and has a very poor prognosis. This condition is considered a provisional entity in the fourth edition of the WHO/EORTC guidelines [1]. This chapter will discuss the clinical presentation, prognosis, treatment, histopathology, immunophenotype, and differential diagnosis of pcGDTCL. It closes with two clinical cases, including clinical images and histopathology.

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Author information

Authors and Affiliations

  1. Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, USA

    Amrita Goyal M.D.

  2. Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Joi B. Carter M.D.

  3. Department of Pathology, Boston Children’s Hospital, Boston, MA, USA

    Alexandra E. Kovach M.D.

  4. Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Thomas S. Kupper M.D., Ph.D.

  5. Dermatopathology Service, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Lyn McDivitt Duncan M.D.

Authors
  1. Amrita Goyal M.D.
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  2. Joi B. Carter M.D.
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  3. Alexandra E. Kovach M.D.
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  4. Thomas S. Kupper M.D., Ph.D.
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  5. Lyn McDivitt Duncan M.D.
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Corresponding author

Correspondence to Lyn McDivitt Duncan M.D. .

Editor information

Editors and Affiliations

  1. Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA

    Joi B. Carter

  2. Division of Health Sciences and Technology, Harvard Medical School, Boston, Massachusetts, USA

    Amrita Goyal

  3. Dermatopathology Service, Massachusetts General Hospital, Boston, Massachusetts, USA

    Lyn McDivitt Duncan

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© 2015 Springer International Publishing Switzerland

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Goyal, A., Carter, J.B., Kovach, A.E., Kupper, T.S., Duncan, L.M. (2015). Primary Cutaneous Gamma-Delta T-Cell Lymphoma. In: Carter, J., Goyal, A., McDivitt Duncan, L. (eds) Atlas of Cutaneous Lymphomas. Springer, Cham. https://doi.org/10.1007/978-3-319-17217-0_13

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  • DOI: https://doi.org/10.1007/978-3-319-17217-0_13

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-17216-3

  • Online ISBN: 978-3-319-17217-0

  • eBook Packages: MedicineMedicine (R0)

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