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Mesothelial Progenitors in Development, Lung Homeostasis, and Tissue Repair

  • Chapter
Lung Stem Cells in the Epithelium and Vasculature

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

In this chapter, we review published information on the emerging field of mesothelial cell biology. The emphasis is on specific markers, function, genetic tools, lineage properties, and signals controlling migration and differentiation. We also discuss the potential role of this cell in endogenous injury responses, inflammation, fibrosis, and tissue regeneration.

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Abbreviations

CD34:

Cluster of differentiation molecule 34

EMT:

Epithelial–mesenchymal transition

HGF:

Hepatocyte growth factor

IL-8, -10, -1:

Interleukin-8, -10, -1

RALDH2:

Retinaldehyde dehydrogenase 2

TGFβ:

Transforming growth factor beta

TNFα:

Tumor necrosis factor alpha

WT1:

Wilm’s tumor1

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Authors and Affiliations

  1. Division of Pulmonary, Allergy, Sleep and Critical Care Medicine, Boston University School of Medicine, 72 E. Concord St Housman (R), Boston, MA, 02118, USA

    Radhika Dixit, Xingbin Ai & Alan Fine M.D.

Authors
  1. Radhika Dixit
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  2. Xingbin Ai
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  3. Alan Fine M.D.
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Corresponding author

Correspondence to Alan Fine M.D. .

Editor information

Editors and Affiliations

  1. Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California, USA

    Amy Firth

  2. Department of Medicine, The Univsersity of Arizona, Tucson, Arizona, USA

    Jason X.-J. Yuan

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Dixit, R., Ai, X., Fine, A. (2015). Mesothelial Progenitors in Development, Lung Homeostasis, and Tissue Repair. In: Firth, A., Yuan, JJ. (eds) Lung Stem Cells in the Epithelium and Vasculature. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-16232-4_10

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