Abstract
For analytical and some small preparative columns in LC, mass transfer resistance is usually negligible and the equilibrium theory suffices [1]. However, for preparative columns with smaller plate numbers and large-scale columns, mass transfer effects are often significant and usually cannot be neglected. The study of mass transfer effects for single-component systems has been carried out by many researchers [2]. For example, Lee et al. [3] studied the mass transfer effects in nonlinear multicomponent elution ion-exchange chromatography. They discussed the differences between a general rate model and the equilibrium theory under various mass transfer conditions.
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Gu, T. (2015). Mass Transfer Effects in Liquid Chromatography Simulation. In: Mathematical Modeling and Scale-Up of Liquid Chromatography. Springer, Cham. https://doi.org/10.1007/978-3-319-16145-7_5
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DOI: https://doi.org/10.1007/978-3-319-16145-7_5
Publisher Name: Springer, Cham
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