Abstract
For the modeling of multicomponent LC, the column is divided into the bulk-fluid phase and the particle phase. The anatomy of a fixed-bed axial flow chromatography column is given in Fig. 3.1. To formulate a general rate model, the following basic assumptions are made:
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bird RB, Stewart WE, Lightfoot EN (2007) Transport phenomena. Wiley, New York
Ruthven DM (1984) Principles of adsorption and adsorption processes. Wiley, New York
Reddy JN (1984) An introduction to the finite element method. McGraw-Hill, New York
Finlayson BA (2003) Nonlinear analysis in chemical engineering. Ravenna Park, Seattle, WA
Brown PN, Byrne GD, Hindmarsh AC (1989) VODE: a variable-coefficient ODE solver. SIAM J Sci Stat Comp 10:1038–1051. doi:10.1137/0910062
Lin B, Golshan-Shirazi S, Ma Z, Guiochon G (1988) Shock effects in nonlinear chromatography. Anal Chem 60:2647–2653
Gu T, Iyer G, Cheng K-SC (2013) Parameter estimation and rate model simulation of partial breakthrough of bovine serum albumin on a column packed with large Q Sepharose anion-exchange particles. Sep Purif Technol 116:319–326
Stroud AH, Secrest D (1966) Gaussian quadrature formulas. Prentice-Hall, London
Danckwerts PV (1953) Continuous flow systems: distribution of residence times. Chem Eng Sci 2:1–13. doi:10.1016/0009-2509(53)80001-1
Parulekar SJ, Ramkrishna D (1984) Analysis of axially dispersed systems with general boundary conditions-I-, II, III. Chem Eng Sci 39:1571–1611. doi:10.1016/0009-2509(84)80085-8
Lee WC, Huang SH, Tsao GT (1988) A unified approach for moments in chromatography. AIChE J 34:2083–2087
Brian BF, Zwiebel I, Artigue RS (1987) Numerical simulation of fixed bed adsorption dynamics by the method of lines. AIChE Symp Ser 83:80–86
Lin B, Ma Z, Guiochon G (1989) Study of the influence of axial dispersion on the band profile in nonlinear chromatography using the Lax-Wendroff method. Sep Sci Technol 24:809–829. doi:10.1080/01496398908049877
Lee W-C, Tsai G-J, Tsao GT (1990) Radial-flow affinity chromatography for trypsin purification. ACS Symp Ser 427:104–117
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Gu, T. (2015). General Multicomponent Rate Model for Column Liquid Chromatography. In: Mathematical Modeling and Scale-Up of Liquid Chromatography. Springer, Cham. https://doi.org/10.1007/978-3-319-16145-7_3
Download citation
DOI: https://doi.org/10.1007/978-3-319-16145-7_3
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-16144-0
Online ISBN: 978-3-319-16145-7
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)