Abstract
High-Performance Liquid Chromatography (HPLC) is undoubtedly one of the most important tools in chemical analysis [1]. It has become increasingly popular at preparative- and large scales, especially in purifying proteins and other high-value products [2]. At these scales, larger particles are often used to pack the columns in order to facilitate column packing and to reduce column pressure. Unlike small-scale analytical HPLC columns that can provide near plug-flow performances, large LC columns suffer from deteriorated performances due to dispersion and other effects.
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Gu, T. (2015). Introduction. In: Mathematical Modeling and Scale-Up of Liquid Chromatography. Springer, Cham. https://doi.org/10.1007/978-3-319-16145-7_1
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DOI: https://doi.org/10.1007/978-3-319-16145-7_1
Publisher Name: Springer, Cham
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