Skip to main content

Abstract

This chapter is devoted to the derivation of the ODE-based model with time delay that is to be analyzed in the forthcoming chapters. In particular, an equivalent simplified mathematical model of the GRN model is proposed through some interpretations of the interconnection scheme. Next, the stability conditions for the linearized system around an equilibrium point are discussed. Finally, a specific example (the repressilator) is given to illustrate the motivation behind the model considered.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. J. Gebert, N. Radde, and G.-W. Weber, “Modeling gene regulatory networks with piecewise linear differential equations,” European Journal of Operational Research, vol. 181, no. 3, pp. 1148–1165, 2007.

    Article  MATH  MathSciNet  Google Scholar 

  2. J. M. Berg, J. L. Tymoczko, and L. Stryer, Biochemistry. W. H. Freeman and Company: New York, 2002.

    Google Scholar 

  3. M. B. Elowitz and S. Leibler, “A synthetic oscillatory network of transcriptional regulators,” Nature, vol. 403, no. 6767, pp. 335–338, 2000.

    Article  Google Scholar 

  4. F. Alves and R. Dilão, “A simple framework to describe the regulation of gene expression in prokaryotes,” Comptes Rendus Biologies, vol. 328, no. 5, pp. 429–444, 2005.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2015 The Author(s)

About this chapter

Cite this chapter

Ahsen, M.E., Özbay, H., Niculescu, SI. (2015). Deterministic ODE-Based Model with Time Delay. In: Analysis of Deterministic Cyclic Gene Regulatory Network Models with Delays. SpringerBriefs in Electrical and Computer Engineering(). Birkhäuser, Cham. https://doi.org/10.1007/978-3-319-15606-4_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-15606-4_4

  • Published:

  • Publisher Name: Birkhäuser, Cham

  • Print ISBN: 978-3-319-15605-7

  • Online ISBN: 978-3-319-15606-4

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics