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Effects of PFOA on Endocrine-Related Systems

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Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

Abstract

Perfluorooctanoic acid (PFOA) is an 8-carbon fully fluorinated chemical that has reported effects on endocrine-related systems in rodents, humans, and other species. Numerous endocrine organs may be targets for PFOA, including the brain, thyroid, pancreas, adipose tissue, ovary, uterus, testes, and breast. Developmental exposure effects have been reported on behavior, serum thyroid and gonadal steroid profiles, breast epithelial growth, and metabolic end points, such as serum insulin, leptin, and triglyceride levels and weight gain. Many of these PFOA-induced effects have been reported in two or more species. The mechanisms for these numerous effects are poorly understood and deserve further investigation to define the pathways that should be avoided as PFOA-replacement products enter the market.

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References

  • Apelberg BJ, Witter FR, Herbstman JB, Calafat AM, Halden RU, Needham LL, Goldman LR (2007) Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth. Environ Health Perspect 115:1670–1676

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Appasamy M, Muttukrishna S, Pizzey AR, Ozturk O, Groome NP, Serhal P, Jauniaux E (2007) Relationship between male reproductive hormones, sperm DNA damage and markers of oxidative stress in infertility. Reprod Biomed Online 14:159–165

    Article  CAS  PubMed  Google Scholar 

  • Baillie-Hamilton PF (2002) Chemical toxins: a hypothesis to explain the global obesity epidemic. J Altern Complement Med 8:185–192

    Article  PubMed  Google Scholar 

  • Barbarossa A, Masetti R, Gazzotti T, Zama D, Astolfi A, Veyrand B, Pession A, Pagliuca G (2013) Perfluoroalkyl substances in human milk: a first survey in Italy. Environ Int 51:27–30

    Article  CAS  PubMed  Google Scholar 

  • Birnbaum LS, Fenton SE (2003) Cancer and developmental exposure to endocrine disruptors. Environ Health Perspect 111:389–394

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Calafat AM, Wong LY, Kuklenyik Z, Reidy JA, Needham LL (2007) Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003–2004 and comparisons with NHANES 1999–2000. Environ Health Perspect 115:1596–1602

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Christensen KY, Maisonet M, Rubin C, Holmes A, Calafat AM, Kato K, Flanders WD, Heron J, Mcgeehin MA, Marcus M (2011) Exposure to polyfluoroalkyl chemicals during pregnancy is not associated with offspring age at menarche in a contemporary British cohort. Environ Int 37:129–135

    Article  CAS  PubMed  Google Scholar 

  • Darrow LA, Stein CR, Steenland K (2013) Serum perfluorooctanoic acid and perfluorooctane sulfonate concentrations in relation to birth outcomes in the Mid-Ohio Valley, 2005–2010. Environ Health Perspect 121:1207–1213

    PubMed Central  CAS  PubMed  Google Scholar 

  • Dixon D, Reed CE, Moore AB, Gibbs-Flournoy EA, Hines EP, Wallace EA, Stanko JP, Lu Y, Jefferson WN, Newbold RR, Fenton SE (2012) Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay. Reprod Toxicol 33:506–512

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Fei C, Mclaughlin JK, Tarone RE, Olsen J (2007) Perfluorinated chemicals and fetal growth: a study within the Danish National Birth Cohort. Environ Health Perspect 115:1677–1682

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Fei C, Mclaughlin JK, Lipworth L, Olsen J (2009) Maternal levels of perfluorinated chemicals and subfecundity. Hum Reprod 24:1200–1205

    Article  CAS  PubMed  Google Scholar 

  • Fenton SE, Reiner JL, Nakayama SF, Delinsky AD, Stanko JP, Hines EP, White SS, Lindstrom AB, Strynar MJ, Petropoulou SS (2009) Analysis of PFOA in dosed CD-1 mice. Part 2. Disposition of PFOA in tissues and fluids from pregnant and lactating mice and their pups. Reprod Toxicol 27:365–372

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Frisbee SJ, Shankar A, Knox SS, Steenland K, Savitz DA, Fletcher T, Ducatman AM (2010) Perfluorooctanoic acid, perfluorooctanesulfonate, and serum lipids in children and adolescents: results from the C8 Health Project. Arch Pediatr Adolesc Med 164:860–869

    Article  PubMed Central  PubMed  Google Scholar 

  • Fromme H, Mosch C, Morovitz M, Alba-Alejandre I, Boehmer S, Kiranoglu M, Faber F, Hannibal I, Genzel-Boroviczeny O, Koletzko B, Volkel W (2010) Pre- and postnatal exposure to perfluorinated compounds (PFCs). Environ Sci Technol 44:7123–7129

    Article  CAS  PubMed  Google Scholar 

  • Gordetsky J, Van Wijngaarden E, O’brien J (2012) Redefining abnormal follicle-stimulating hormone in the male infertility population. BJU Int 110:568–572

    Article  CAS  PubMed  Google Scholar 

  • Grun F, Blumberg B (2009) Endocrine disrupters as obesogens. Mol Cell Endocrinol 304:19–29

    Article  PubMed Central  PubMed  Google Scholar 

  • Gueorguiev M, Goth ML, Korbonits M (2001) Leptin and puberty: a review. Pituitary 4:79–86

    Article  CAS  PubMed  Google Scholar 

  • Guerre-Millo M (2002) Adipose tissue hormones. J Endocrinol Invest 25:855–861

    Article  CAS  PubMed  Google Scholar 

  • Gutzkow KB, Haug LS, Thomsen C, Sabaredzovic A, Becher G, Brunborg G (2012) Placental transfer of perfluorinated compounds is selective – a Norwegian Mother and Child sub-cohort study. Int J Hyg Environ Health 215:216–219

    Article  PubMed  Google Scholar 

  • Halldorsson TI, Rytter D, Haug LS, Bech BH, Danielsen I, Becher G, Henriksen TB, Olsen SF (2012) Prenatal exposure to perfluorooctanoate and risk of overweight at 20 years of age: a prospective cohort study. Environ Health Perspect 120:668–673

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Hamm MP, Cherry NM, Chan E, Martin JW, Burstyn I (2010) Maternal exposure to perfluorinated acids and fetal growth. J Expo Sci Environ Epidemiol 20:589–597

    Article  CAS  PubMed  Google Scholar 

  • Hanssen L, Rollin H, Odland JO, Moe MK, Sandanger TM (2010) Perfluorinated compounds in maternal serum and cord blood from selected areas of South Africa: results of a pilot study. J Environ Monit 12:1355–1361

    Article  CAS  PubMed  Google Scholar 

  • Harwood HJ Jr (2012) The adipocyte as an endocrine organ in the regulation of metabolic homeostasis. Neuropharmacology 63:57–75

    Article  CAS  PubMed  Google Scholar 

  • Haug LS, Huber S, Becher G, Thomsen C (2011) Characterisation of human exposure pathways to perfluorinated compounds–comparing exposure estimates with biomarkers of exposure. Environ Int 37:687–693

    Article  CAS  PubMed  Google Scholar 

  • Hinderliter PM, Mylchreest E, Gannon SA, Butenhoff JL, Kennedy GL Jr (2005) Perfluorooctanoate: placental and lactational transport pharmacokinetics in rats. Toxicology 211:139–148

    Article  CAS  Google Scholar 

  • Hines EP, White SS, Stanko JP, Gibbs-Flournoy EA, Lau C, Fenton SE (2009) Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: low doses induce elevated serum leptin and insulin, and overweight in mid-life. Mol Cell Endocrinol 304:97–105

    Article  CAS  PubMed  Google Scholar 

  • Huang YF, Wu KY, Liou SH, Uang SN, Chen CC, Shih WC, Lee SC, Huang CC, Chen ML (2011) Biological monitoring for occupational acrylamide exposure from acrylamide production workers. Int Arch Occup Environ Health 84:303–313

    Article  CAS  PubMed  Google Scholar 

  • Inoue K, Okada F, Ito R, Kato S, Sasaki S, Nakajima S, Uno A, Saijo Y, Sata F, Yoshimura Y, Kishi R, Nakazawa H (2004) Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds in human maternal and cord blood samples: assessment of PFOS exposure in a susceptible population during pregnancy. Environ Health Perspect 112:1204–1207

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Jain RB (2013) Association between thyroid profile and perfluoroalkyl acids: data from NHNAES 2007–2008. Environ Res 126:51–59

    Article  CAS  PubMed  Google Scholar 

  • Javins B, Hobbs G, Ducatman AM, Pilkerton C, Tacker D, Knox SS (2013) Circulating maternal perfluoroalkyl substances during pregnancy in the C8 Health Study. Environ Sci Technol 47:1606–1613

    CAS  PubMed  Google Scholar 

  • Joensen UN, Bossi R, Leffers H, Jensen AA, Skakkebaek NE, Jorgensen N (2009) Do perfluoroalkyl compounds impair human semen quality? Environ Health Perspect 117:923–927

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Karrman A, Ericson I, Van Bavel B, Darnerud PO, Aune M, Glynn A, Lignell S, Lindstrom G (2007) Exposure of perfluorinated chemicals through lactation: levels of matched human milk and serum and a temporal trend, 1996–2004, in Sweden. Environ Health Perspect 115:226–230

    Article  PubMed Central  PubMed  Google Scholar 

  • Kim SK, Lee KT, Kang CS, Tao L, Kannan K, Kim KR, Kim CK, Lee JS, Park PS, Yoo YW, Ha JY, Shin YS, Lee JH (2011) Distribution of perfluorochemicals between sera and milk from the same mothers and implications for prenatal and postnatal exposures. Environ Pollut 159:169–174

    Article  CAS  PubMed  Google Scholar 

  • Knox SS, Jackson T, Frisbee SJ, Javins B, Ducatman AM (2011) Perfluorocarbon exposure, gender and thyroid function in the C8 Health Project. J Toxicol Sci 36:403–410

    Article  PubMed  Google Scholar 

  • Kristensen SL, Ramlau-Hansen CH, Ernst E, Olsen SF, Bonde JP, Vested A, Halldorsson TI, Becher G, Haug LS, Toft G (2013) Long-term effects of prenatal exposure to perfluoroalkyl substances on female reproduction. Hum Reprod 28:3337–3348

    Article  CAS  PubMed  Google Scholar 

  • Lam J, Koustas E, Sutton P, Johnson PI, Atchley DS, Sen S (2014) The navigation guide – evidence-based medicine meets environmental health: integration of animal and human evidence for PFOA effects on fetal growth. Environ Health Perspect 122:1040–1051

    PubMed Central  PubMed  Google Scholar 

  • Landrigan PJ, Sonawane B, Mattison D, Mccally M, Garg A (2002) Chemical contaminants in breast milk and their impacts on children’s health: an overview. Environ Health Perspect 110:A313–A315

    Article  PubMed Central  PubMed  Google Scholar 

  • Lau C, Thibodeaux JR, Hanson RG, Rogers JM, Grey BE, Stanton ME, Butenhoff JL, Stevenson LA (2003) Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation. Toxicol Sci 74:382–392

    Article  CAS  Google Scholar 

  • Lau C, Thibodeaux JR, Hanson RG, Narotsky MG, Rogers JM, Lindstrom AB, Strynar MJ (2006) Effects of perfluorooctanoic acid exposure during pregnancy in the mouse. Toxicol Sci 90:510–518

    Article  CAS  PubMed  Google Scholar 

  • Lau C, Anitole K, Hodes C, Lai D, Pfahles-Hutchens A, Seed J (2007) Perfluoroalkyl acids: a review of monitoring and toxicological findings. Toxicol Sci 99:366–394

    Article  CAS  PubMed  Google Scholar 

  • Lin CY, Wen LL, Lin LY, Wen TW, Lien GW, Hsu SH, Chien KL, Liao CC, Sung FC, Chen PC, Su TC (2013) The associations between serum perfluorinated chemicals and thyroid function in adolescents and young adults. J Hazard Mater 244–245:637–644

    Article  PubMed  Google Scholar 

  • Liu J, Li J, Liu Y, Chan HM, Zhao Y, Cai Z, Wu Y (2011) Comparison on gestation and lactation exposure of perfluorinated compounds for newborns. Environ Int 37:1206–1212

    Article  CAS  PubMed  Google Scholar 

  • Lopez-Espinosa MJ, Fletcher T, Armstrong B, Genser B, Dhatariya K, Mondal D, Ducatman A, Leonardi G (2011) Association of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) with age of puberty among children living near a chemical plant. Environ Sci Technol 45:8160–8166

    Article  CAS  PubMed  Google Scholar 

  • Lopez-Espinosa MJ, Mondal D, Armstrong B, Bloom MS, Fletcher T (2012) Thyroid function and perfluoroalkyl acids in children living near a chemical plant. Environ Health Perspect 120:1036–1041

    Article  PubMed Central  PubMed  Google Scholar 

  • Lyngso J, Ramlau-Hansen CH, Hoyer BB, Stovring H, Bonde JP, Jonsson BA, Lindh CH, Pedersen HS, Ludwicki JK, Zviezdai V, Toft G (2014) Menstrual cycle characteristics in fertile women from Greenland, Poland and Ukraine exposed to perfluorinated chemicals: a cross-sectional study. Hum Reprod 29:359–367

    Article  CAS  PubMed  Google Scholar 

  • Macon MB, Villanueva LR, Tatum-Gibbs K, Zehr RD, Strynar MJ, Stanko JP, White SS, Helfant L, Fenton SE (2011) Prenatal perfluorooctanoic acid exposure in CD-1 mice: low-dose developmental effects and internal dosimetry. Toxicol Sci 122:134–145

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Macon MB, Ren H, Fenton SE Prenatal PFOA exposure alters gene expression pathways in neonate murine mammary gland. Toxicol Sci (in press) http://dx.doi.org/10.1093/toxsci/kfu253 (Epub ahead of print)

  • Melzer D, Rice N, Depledge MH, Henley WE, Galloway TS (2010) Association between serum perfluorooctanoic acid (PFOA) and thyroid disease in the U.S. National Health and Nutrition Examination Survey. Environ Health Perspect 118:686–692

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Midasch O, Drexler H, Hart N, Beckmann MW, Angerer J (2007) Transplacental exposure of neonates to perfluorooctanesulfonate and perfluorooctanoate: a pilot study. Int Arch Occup Environ Health 80:643–648

    Article  CAS  PubMed  Google Scholar 

  • Mondal D, Lopez-Espinosa MJ, Armstrong B, Stein CR, Fletcher T (2012) Relationships of perfluorooctanoate and perfluorooctane sulfonate serum concentrations between mother-child pairs in a population with perfluorooctanoate exposure from drinking water. Environ Health Perspect 120:752–757

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Mondal D, Weldon RH, Armstrong BG, Gibson LJ, Lopez-Espinosa MJ, Shin HM, Fletcher T (2014) Breastfeeding: a potential excretion route for mothers and implications for infant exposure to perfluoroalkyl acids. Environ Health Perspect 122:187–192

    PubMed Central  PubMed  Google Scholar 

  • Monroy R, Morrison K, Teo K, Atkinson S, Kubwabo C, Stewart B, Foster WG (2008) Serum levels of perfluoroalkyl compounds in human maternal and umbilical cord blood samples. Environ Res 108:56–62

    Article  CAS  PubMed  Google Scholar 

  • Needham LL, Grandjean P, Heinzow B, Jorgensen PJ, Nielsen F, Patterson DG Jr, Sjodin A, Turner WE, Weihe P (2011) Partition of environmental chemicals between maternal and fetal blood and tissues. Environ Sci Technol 45:1121–1126

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Nelson JW, Hatch EE, Webster TF (2010) Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population. Environ Health Perspect 118:197–202

    Article  PubMed Central  CAS  Google Scholar 

  • Newbold RR (2010) Impact of environmental endocrine disrupting chemicals on the development of obesity. Hormones (Athens) 9:206–217

    Article  Google Scholar 

  • Nolan LA, Nolan JM, Shofer FS, Rodway NV, Emmett EA (2009) The relationship between birth weight, gestational age and perfluorooctanoic acid (PFOA)-contaminated public drinking water. Reprod Toxicol 27:231–238

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Olsen GW, Zobel LR (2007) Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers. Int Arch Occup Environ Health 81:231–246

    Article  CAS  PubMed  Google Scholar 

  • Olsen GW, Gilliland FD, Burlew MM, Burris JM, Mandel JS, Mandel JH (1998) An epidemiologic investigation of reproductive hormones in men with occupational exposure to perfluorooctanoic acid. J Occup Environ Med 40:614–622

    Article  CAS  Google Scholar 

  • Olsen GW, Butenhoff JL, Zobel LR (2009) Perfluoroalkyl chemicals and human fetal development: an epidemiologic review with clinical and toxicological perspectives. Reprod Toxicol 27:212–230

    Article  CAS  PubMed  Google Scholar 

  • Pinney SM, Windham GC, Biro FM, Kushi LH, Yaghjyan L, Calafat AM, Kato K, Succop P, Brown MK, Hernick A, Bornschein R (2009) Perfluorooctanoic acid (PFOA) and pubertal maturation in young girls. Epidemiology 20:S80

    Article  Google Scholar 

  • Pinney SM, Biro FM, Windham GC, Herrick RL, Yaghjyan L, Calafat AM, Succop P, Sucharew H, Ball KM, Kato K, Kushi LH, Bornschein R (2014) Serum biomarkers of polyfluoroalkyl compound exposure in young girls in Greater Cincinnati and the San Francisco Bay Area, USA. Environ Pollut 184:327–334

    Article  CAS  PubMed  Google Scholar 

  • Post GB, Cohn PD, Cooper KR (2012) Perfluorooctanoic acid (PFOA), an emerging drinking water contaminant: a critical review of recent literature. Environ Res 116:93–117

    Article  CAS  PubMed  Google Scholar 

  • Quist EM, Filgo AJ, Cummings C, Kissling GE, Hoenerhoff MJ, Fenton SE (in press) Hepatic mitochondrial alteration in CD-1 mice associated with prenatal exposures to low doses of perfluorooctanoic acid (PFOA). Toxicol Pathol. http://dx.doi.org/10.1177/0192623314551841 (Epub ahead of print)

  • Tucker DK, Macon MB, Strynar MJ, Dagnino S, Andersen E, Fenton SE (in press) The mammary gland is a sensitive pubertal target in CD-1 and C57Bl/6 mice following perinatal perfluorooctanoic acid (PFOA) exposure. Reprod Toxicol. http://dx.doi.org/10.1016/j.reprotox.2014.12.002 (Epub ahead of print)

  • Savitz DA, Stein CR, Elston B, Wellenius GA, Bartell SM, Shin HM, Vieira VM, Fletcher T (2012) Relationship of perfluorooctanoic acid exposure to pregnancy outcome based on birth records in the mid-Ohio Valley. Environ Health Perspect 120:1201–1207

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Song M, Kim YJ, Park YK, Ryu JC (2012) Changes in thyroid peroxidase activity in response to various chemicals. J Environ Monit 14:2121–2126

    Article  CAS  PubMed  Google Scholar 

  • Starling AP, Engel SM, Richardson DB, Baird DD, Haug LS, Stuebe AM, Klungsoyr K, Harmon Q, Becher G, Thomsen C, Sabaredzovic A, Eggesbo M, Hoppin JA, Travlos GS, Wilson RE, Trogstad LI, Magnus P, Longnecker MP (2014a) Perfluoroalkyl substances during pregnancy and validated preeclampsia among nulliparous women in the Norwegian Mother and Child Cohort Study. Am J Epidemiol 179:824–833

    Article  PubMed Central  PubMed  Google Scholar 

  • Starling AP, Engel SM, Whitworth KW, Richardson DB, Stuebe AM, Daniels JL, Haug LS, Eggesbo M, Becher G, Sabaredzovic A, Thomsen C, Wilson RE, Travlos GS, Hoppin JA, Baird DD, Longnecker MP (2014b) Perfluoroalkyl substances and lipid concentrations in plasma during pregnancy among women in the Norwegian Mother and Child Cohort Study. Environ Int 62:104–112

    Article  CAS  PubMed  Google Scholar 

  • Stein CR, Savitz DA, Dougan M (2009) Serum levels of perfluorooctanoic acid and perfluorooctane sulfonate and pregnancy outcome. Am J Epidemiol 170:837–846

    Article  PubMed  Google Scholar 

  • Tao L, Kannan K, Wong CM, Arcaro KF, Butenhoff JL (2008) Perfluorinated compounds in human milk from Massachusetts, U.S.A. Environ Sci Technol 42:3096–3101

    Article  CAS  PubMed  Google Scholar 

  • Toft G, Jonsson BA, Lindh CH, Giwercman A, Spano M, Heederik D, Lenters V, Vermeulen R, Rylander L, Pedersen HS, Ludwicki JK, Zviezdai V, Bonde JP (2012) Exposure to perfluorinated compounds and human semen quality in Arctic and European populations. Hum Reprod 27:2532–2540

    Article  CAS  PubMed  Google Scholar 

  • Vested A, Ramlau-Hansen CH, Olsen SF, Bonde JP, Kristensen SL, Halldorsson TI, Becher G, Haug LS, Ernst EH, Toft G (2013) Associations of in utero exposure to perfluorinated alkyl acids with human semen quality and reproductive hormones in adult men. Environ Health Perspect 121:453–458, 458e1-5

    PubMed Central  PubMed  Google Scholar 

  • Vestergaard S, Nielsen F, Andersson AM, Hjollund NH, Grandjean P, Andersen HR, Jensen TK (2012) Association between perfluorinated compounds and time to pregnancy in a prospective cohort of Danish couples attempting to conceive. Hum Reprod 27:873–880

    Article  CAS  PubMed  Google Scholar 

  • Von Ehrenstein OS, Fenton SE, Kato K, Kuklenyik Z, Calafat AM, Hines EP (2009) Polyfluoroalkyl chemicals in the serum and milk of breastfeeding women. Reprod Toxicol 27:239–245

    Article  Google Scholar 

  • Washino N, Saijo Y, Sasaki S, Kato S, Ban S, Konishi K, Ito R, Nakata A, Iwasaki Y, Saito K, Nakazawa H, Kishi R (2009) Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth. Environ Health Perspect 117:660–667

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • White SS, Calafat AM, Kuklenyik Z, Villanueva L, Zehr RD, Helfant L, Strynar MJ, Lindstrom AB, Thibodeaux JR, Wood C, Fenton SE (2007) Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring. Toxicol Sci 96:133–144

    Article  CAS  PubMed  Google Scholar 

  • White SS, Fenton SE, Hines EP (2011a) Endocrine disrupting properties of perfluorooctanoic acid. J Steroid Biochem Mol Biol 127:16–26

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • White SS, Stanko JP, Kato K, Calafat AM, Hines EP, Fenton SE (2011b) Gestational and chronic low-dose PFOA exposures and mammary gland growth and differentiation in three generations of CD-1 mice. Environ Health Perspect 119:1070–1076

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Whitworth KW, Haug LS, Baird DD, Becher G, Hoppin JA, Skjaerven R, Thomsen C, Eggesbo M, Travlos G, Wilson R, Longnecker MP (2012) Perfluorinated compounds and subfecundity in pregnant women. Epidemiology 23:257–263

    Article  PubMed Central  PubMed  Google Scholar 

  • Winquist A, Steenland K (2014) Perfluorooctanoic acid exposure and thyroid disease in community and worker cohorts. Epidemiology 25:255–264

    Article  PubMed  Google Scholar 

  • Winquist A, Lally C, Shin HM, Steenland K (2013) Design, methods, and population for a study of PFOA health effects among highly exposed mid-Ohio valley community residents and workers. Environ Health Perspect 121:893–899

    Article  PubMed Central  PubMed  Google Scholar 

  • Yang C, Tan YS, Harkema JR, Haslam SZ (2009) Differential effects of peripubertal exposure to perfluorooctanoic acid on mammary gland development in C57Bl/6 and Balb/c mouse strains. Reprod Toxicol 27:299–306

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Zhao Y, Tan YS, Strynar MJ, Perez G, Haslam SZ, Yang C (2012) Perfluorooctanoic acid effects on ovaries mediate its inhibition of peripubertal mammary gland development in Balb/c and C57Bl/6 mice. Reprod Toxicol 33:563–576

    Article  PubMed Central  CAS  PubMed  Google Scholar 

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Acknowledgements

This work was supported by the National Toxicology Program, National Institute of Environmental Health Sciences, NIH.

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  1. National Toxicology Program (NTP) Laboratory, Division of the NTP, National Institute of Environmental Health Sciences NIEHS/NIH, DHHS, 111 TW Alexander Dr, Bldg 101, MD E1-08, Research Triangle Park, NC, 27709, USA

    Casey E. Reed & Suzanne E. Fenton Ph.D.

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  2. Suzanne E. Fenton Ph.D.
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Correspondence to Suzanne E. Fenton Ph.D. .

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  1. Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA

    Jamie C. DeWitt

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Reed, C.E., Fenton, S.E. (2015). Effects of PFOA on Endocrine-Related Systems. In: DeWitt, J. (eds) Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances. Molecular and Integrative Toxicology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-15518-0_11

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