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Wound Inflammation: Emerging Role of miRNA

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MicroRNAs and Other Non-Coding RNAs in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Wound inflammation occurs in response to injury. It is a coordinated process involving tissues, cells, and an array of soluble, cell-associated, and intracellular factors. The role of certain microRNAs in wound healing and inflammation, in particular (a key process underpinning wound healing), has emerged in recent years. Here, mechanisms involving inflammatory cells, secreted molecules, and miRNAs that can affect wound healing are reviewed. Of interest miR-155, miR-146a, and miR-21, among others, have been shown to have a number of specialized roles in the inflammatory process, Toll-like receptor signaling, and efferocytosis. Other important miRNAs that regulate inflammation are also discussed.

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Acknowledgement

Supported by NIH grant GM077185, GM069589, NR013898 to CKS and NIH DK076566 to SR.

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  1. Heart and Lung Research Institute, Ohio State University Medical Center, Columbus, OH, USA

    Amitava Das, Scott Chaffee, Chandan K. Sen & Sashwati Roy

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  1. Amitava Das
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Correspondence to Sashwati Roy .

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  1. Respiratory Research, Department of Medicine, Royal College of Surgeon in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland

    Catherine M. Greene

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Das, A., Chaffee, S., Sen, C.K., Roy, S. (2015). Wound Inflammation: Emerging Role of miRNA. In: Greene, C. (eds) MicroRNAs and Other Non-Coding RNAs in Inflammation. Progress in Inflammation Research. Springer, Cham. https://doi.org/10.1007/978-3-319-13689-9_7

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