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Allogeneic Hematopoietic Cell Transplantation in Non-Hodgkin’s Lymphomas

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Non-Hodgkin Lymphoma

Part of the book series: Cancer Treatment and Research ((CTAR,volume 165))

Abstract

Allogeneic hematopoietic cell transplant (alloHCT) has emerged as a potential curative treatment for advanced non-Hodgkin’s lymphoma (NHL), especially for patients with chemorefractory disease, relapsed after prior autologous HCT and those with relapsed lymphoma who failed to collect adequate stem cells for autologous HCT. There are several phase II studies supported the role of alloHCT in low-grade lymphomas, but the data is scarce on the other subtypes of lymphomas. However, retrospective registries studies highlighted the inferior outcomes of alloHCT in aggressive lymphomas, with unacceptable higher relapse rate and non-relapse mortality when compared to low-grade lymphomas. Patients with chemorefractory disease and those with active disease at alloHCT had poor outcome. Therefore, incorporation of new target therapies to induce remission prior to transplant or as a bridge to alloHCT may lead to better outcome of alloHCT in NHL. Furthermore, well design prospective studies of alloHCT in NHL and employment of novel transplant approaches tailored toward specific histological subtype are urgently needed.

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References

  1. Khouri IF, Saliba RM, Erwin WD et al (2012) Nonmyeloablative allogeneic transplantation with or without 90yttrium ibritumomab tiuxetan is potentially curative for relapsed follicular lymphoma: 12-year results. Blood 119:6373–6378

    Article  CAS  PubMed  Google Scholar 

  2. Shea T, Johnson J, Westervelt P et al (2011) Reduced-intensity allogeneic transplantation provides high event-free and overall survival in patients with advanced indolent B cell malignancies: CALGB 109901. Biol Blood Marrow Transplant 17:1395–1403

    Article  PubMed Central  PubMed  Google Scholar 

  3. Piñana JL, Martino R, Gayoso J et al (2010) Reduced intensity conditioning HLA identical sibling donor allogeneic stem cell transplantation for patients with follicular lymphoma: long-term follow-up from two prospective multicenter trials. Haematologica 95:1176–1182

    Article  PubMed Central  PubMed  Google Scholar 

  4. S Cohen, Kiss T, Lachance S et al (2012) Tandem autologous-allogeneic nonmyeloablative sibling transplantation in relapsed follicular lymphoma leads to impressive progression-free survival with minimal toxicity. Biol Blood Marrow Transplant 18:951–957

    Article  Google Scholar 

  5. Hari P, Carreras J, Zhang MJ et al (2008) Allogeneic transplants in follicular lymphoma: higher risk of disease progression after reduced-intensity compared to myeloablative conditioning. Biol Blood Marrow Transplant. 14:236–245

    Article  PubMed Central  PubMed  Google Scholar 

  6. Avivi I, Montoto S, Canals C et al (2009) Matched unrelated donor stem cell transplant in 131 patients with follicular lymphoma: an analysis from the lymphoma working party of the European group for blood and marrow transplantation. Br J Haematol 147:719–728

    Article  PubMed  Google Scholar 

  7. Thomson KJ, Morris EC, Milligan D et al (2010) T-cell-depleted reduced-intensity transplantation followed by donor leukocyte infusions to promote graft-versus-lymphoma activity results in excellent long-term survival in patients with multiply relapsed follicular lymphoma. J Clin Oncol 28:3695–3700

    Article  PubMed  Google Scholar 

  8. Ito Y, Miyamoto T, Kamimura T et al (2013) Clinical outcomes of allogeneic stem cell transplantation for relapsed or refractory follicular lymphoma: a retrospective analysis by the fukuoka blood and marrow transplantation group. Int J Hematol 98:463–471

    Article  CAS  PubMed  Google Scholar 

  9. Philip T, Guglielmi C, Hagenbeek A et al (1995) Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin’s lymphoma. N Engl J Med 333:1540–1545

    Article  CAS  PubMed  Google Scholar 

  10. Gisselbrecht C, Glass B, Mounier N et al (2010) Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era. J Clin Oncol 28:4184–4190

    Article  PubMed Central  PubMed  Google Scholar 

  11. Bacher U, Klyuchnikov E, Le-Rademacher J et al (2012) Conditioning regimens for allotransplants for diffuse large B-cell lymphoma: myeloablative or reduced intensity? Blood 120:4256–4262

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Lazarus HM, Zhang MJ, Carreras J et al (2010) A comparison of HLA-identical sibling allogeneic versus autologous transplantation for diffuse large B cell lymphoma: a report from the CIBMTR. Biol Blood Marrow Transplant. 16:35–45

    Article  PubMed Central  PubMed  Google Scholar 

  13. van Kampen RJ, Canals C et al (2011) Allogeneic stem-cell transplantation as salvage therapy for patients with diffuse large B-cell non-Hodgkin’s lymphoma relapsing after an autologous stem-cell transplantation: an analysis of the European group for blood and marrow transplantation registry. J Clin Oncol 29:1342–1348

    Article  PubMed  Google Scholar 

  14. Rigacci L, Puccini B, Dodero A et al (2012) Allogeneic hematopoietic stem cell transplantation in patients with diffuse large B cell lymphoma relapsed after autologous stem cell transplantation: a GITMO study. Ann Hematol 91:931–939

    Article  PubMed  Google Scholar 

  15. Rezvani AR, Norasetthada L, Gooley T et al (2008) Non-myeloablative allogeneic haematopoietic cell transplantation for relapsed diffuse large B-cell lymphoma: a multicentre experience. Br J Haematol 143:395–403

    Article  PubMed Central  PubMed  Google Scholar 

  16. Aksentijevich I, Jones RJ, Ambinder RF et al (2006) Clinical outcome following autologous and allogeneic blood and marrow transplantation for relapsed diffuse large-cell non-Hodgkin’s lymphoma. Biol Blood Marrow Transplant. 12:965–972

    Article  PubMed  Google Scholar 

  17. Thomson KJ, Morris EC, Bloor A et al (2009) Favorable long-term survival after reduced-intensity allogeneic transplantation for multiple-relapse aggressive non-Hodgkin’s lymphoma. J Clin Oncol 20(27):426–432

    Google Scholar 

  18. Sirvent A, Dhedin N, Michallet M et al (2010) Low nonrelapse mortality and prolonged long-term survival after reduced-intensity allogeneic stem cell transplantation for relapsed or refractory diffuse large B cell lymphoma: report of the société française de greffe de moelle et de thérapie cellulaire. Biol Blood Marrow Transplant 16:78–85

    Article  PubMed  Google Scholar 

  19. Maramattom LV, Hari PN, Burns LJ et al (2013) Autologous and allogeneic transplantation for Burkitt lymphoma outcomes and changes in utilization: a report from the center for international blood and marrow transplant research. Biol Blood Marrow Transplant 19:173–179

    Article  PubMed Central  PubMed  Google Scholar 

  20. Cwynarski K, van Biezen A, de Wreede L et al (2012) Autologous and allogeneic stem-cell transplantation for transformed chronic lymphocytic leukemia (Richter’s syndrome): a retrospective analysis from the chronic lymphocytic leukemia subcommittee of the chronic leukemia working party and lymphoma working party. J Clin Oncol 30:2211–2217

    Article  PubMed  Google Scholar 

  21. Villa D, Crump M, Panzarella T et al (2013) Autologous and allogeneic stem-cell transplantation for transformed follicular lymphoma: a report of the Canadian blood and marrow transplant group. J Clin Oncol 31:1164–1171

    Article  CAS  PubMed  Google Scholar 

  22. Fenske TS, Zhang MJ, Carreras J et al (2014) Autologous or reduced-intensity conditioning allogeneic hematopoietic cell transplantation for chemotherapy-sensitive mantle-cell lymphoma: analysis of transplantation timing and modality. J Clin Oncol 32:273–281

    Article  PubMed Central  PubMed  Google Scholar 

  23. Hamadani M, Saber W, Ahn KW et al (2013) Allogeneic hematopoietic cell transplantation for chemotherapy-unresponsive mantle cell lymphoma: a cohort analysis from the center for international blood and marrow transplant research. Biol Blood Marrow Transplant 19:625–631

    Article  PubMed Central  PubMed  Google Scholar 

  24. Dietrich S, Boumendil A, Finel H et al (2014) Outcome and prognostic factors in patients with mantle-cell lymphoma relapsing after autologous stem cell transplantation: a retrospective study of the European group for blood and marrow transplantation (EBMT). Ann Oncol 25:1053–1058

    Article  CAS  PubMed  Google Scholar 

  25. Cook G, Smith GM, Kirkland K et al (2010) Outcome following reduced-intensity allogeneic stem cell transplantation (RIC AlloSCT) for relapsed and refractory mantle cell lymphoma (MCL): a study of the British society for blood and marrow transplantation. Biol Blood Marrow Transplant 16:1419–1427

    Article  PubMed  Google Scholar 

  26. Le Gouill S, Kröger N, Dhedin N et al (2012) Reduced-intensity conditioning allogeneic stem cell transplantation for relapsed/refractory mantle cell lymphoma: a multicenter experience. Ann Oncol 23:2695–2703

    Article  PubMed  Google Scholar 

  27. Tam CS, Bassett R, Ledesma C et al (2009) Mature results of the M. D. Anderson Cancer Center risk-adapted transplantation strategy in mantle cell lymphoma. Blood 113:4144–4152

    Article  CAS  PubMed  Google Scholar 

  28. Maris MB, Sandmaier BM, Storer BE et al (2004) Allogeneic hematopoietic cell transplantation after fludarabine and 2 Gy total body irradiation for relapsed and refractory mantle cell lymphoma. Blood 104:3535–3542

    Article  CAS  PubMed  Google Scholar 

  29. Corradini P, Dodero A, Zallio F et al (2004) Graft-versus-lymphoma effect in relapsed peripheral T-cell non-Hodgkin’s lymphomas after reduced-intensity conditioning followed by allogeneic transplantation of hematopoietic cells. J Clin Oncol 22:2172–2176

    Article  PubMed  Google Scholar 

  30. Dodero A, Spina F, Narni F et al (2012) Allogeneic transplantation following a reduced-intensity conditioning regimen in relapsed/refractory peripheral T-cell lymphomas: long-term remissions and response to donor lymphocyte infusions support the role of a graft-versus-lymphoma effect. Leukemia 26:520–526

    Article  CAS  PubMed  Google Scholar 

  31. Smith SM, Burns LJ, van Besien K et al (2013) Hematopoietic cell transplantation for systemic mature T-cell non-Hodgkin lymphoma. J Clin Oncol 31:3100–3109

    Article  PubMed Central  PubMed  Google Scholar 

  32. Kanakry JA, Kasamon YL, Gocke CD et al (2013) Outcomes of related donor HLA-identical or HLA-haploidentical allogeneic blood or marrow transplantation for peripheral T cell lymphoma. Biol Blood Marrow Transplant 19:602–606

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  33. Le Gouill S, Milpied N, Buzyn A et al (2008) Graft-versus-lymphoma effect for aggressive T-cell lymphomas in adults: a study by the Société Francaise de Greffe de Moëlle et de Thérapie Cellulaire. J Clin Oncol 26:2264–2271

    Article  PubMed  Google Scholar 

  34. Kyriakou C, Canals C, Finke J et al (2009) Allogeneic stem cell transplantation is able to induce long-term remissions in angioimmunoblastic T-cell lymphoma: a retrospective study from the lymphoma working party of the European group for blood and marrow transplantation. J Clin Oncol 27:3951–3958

    Article  PubMed  Google Scholar 

  35. Fukushima T, Miyazaki Y, Honda S et al (2005) Allogeneic hematopoietic stem cell transplantation provides sustained long-term survival for patients with adult T-cell leukemia/lymphoma. Leukemia 19:829–834

    Article  CAS  PubMed  Google Scholar 

  36. Kato K, Kanda Y, Eto T, Muta T et al (2007) Allogeneic bone marrow transplantation from unrelated human T-cell leukemia virus-I-negative donors for adult T-cell leukemia/lymphoma: retrospective analysis of data from the Japan marrow donor program. Biol Blood Marrow Transplant 13:90–99

    Article  PubMed  Google Scholar 

  37. Okamura J, Uike N, Utsunomiya A, Tanosaki R (2007) Allogeneic stem cell transplantation for adult T-cell leukemia/lymphoma. Int J Hematol 86:118–125

    Article  PubMed  Google Scholar 

  38. Murashige N, Kami M, Kishi Y et al (2005) Allogeneic haematopoietic stem cell transplantation as a promising treatment for natural killer-cell neoplasms. Br J Haematol 130:561–567

    Article  PubMed  Google Scholar 

  39. Duvic M, Donato M, Dabaja B et al (2010) Total skin electron beam and non-myeloablative allogeneic hematopoietic stem-cell transplantation in advanced mycosis fungoides and Sezary syndrome. J Clin Oncol 28:2365–2372

    Article  PubMed  Google Scholar 

  40. Molina A, Zain J, Arber DA et al (2005) Durable clinical, cytogenetic, and molecular remissions after allogeneic hematopoietic cell transplantation for refractory Sezary syndrome and mycosis fungoides. J Clin Oncol 23:6163–6171

    Article  PubMed  Google Scholar 

  41. Duarte RF, Canals C, Onida F et al (2010) Allogeneic hematopoietic cell transplantation for patients with mycosis fungoides and Sézary syndrome: a retrospective analysis of the lymphoma working party of the European group for blood and marrow transplantation. J Clin Oncol 28:4492–4499

    Article  PubMed  Google Scholar 

  42. Wu PA, Kim YH, Lavori PW et al (2009) A meta-analysis of patients receiving allogeneic or autologous hematopoietic stem cell transplant in mycosis fungoides and Sezary syndrome. Biol Blood Marrow Transplant 15:982–990

    Article  PubMed  Google Scholar 

  43. Rodriguez R, Nademanee A, Ruel N et al (2006) Comparison of reduced-intensity and conventional myeloablative regimens for allogeneic transplantation in non-Hodgkin’s lymphoma. Biol Blood Marrow Transplant 12:1326–1334

    Article  PubMed  Google Scholar 

  44. Rodrigues CA, Rocha V, Dreger P et al (2014) Alternative donor hematopoietic stem cell transplantation for mature lymphoid malignancies after reduced-intensity conditioning regimen: similar outcomes with umbilical cord blood and unrelated donor peripheral blood. Haematologica 99:370–377

    Article  PubMed Central  PubMed  Google Scholar 

  45. Castagna L, Boubdallah R, Furst S et al (2013) Disease status is a more reliable predictive factor than histology in lymphoma patients after reduced-intensity conditioning regimen and allo-SCT. Bone Marrow Transplant 48:794–798

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. City of Hope National Medical Center, Hematology and Hematopoietic Cell Transplantation, 1500 East Duarte Road, Duarte, CA, 91010, USA

    Ibrahim Aldoss & Auayporn Nademanee

Authors
  1. Ibrahim Aldoss
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  2. Auayporn Nademanee
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Correspondence to Auayporn Nademanee .

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Editors and Affiliations

  1. Division of Hematology/Oncology, Tufts Medical Center, Boston, Massachusetts, USA

    Andrew M. Evens

  2. Division of Hematology, Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA

    Kristie A. Blum

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Aldoss, I., Nademanee, A. (2015). Allogeneic Hematopoietic Cell Transplantation in Non-Hodgkin’s Lymphomas. In: Evens, A., Blum, K. (eds) Non-Hodgkin Lymphoma. Cancer Treatment and Research, vol 165. Springer, Cham. https://doi.org/10.1007/978-3-319-13150-4_14

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  • DOI: https://doi.org/10.1007/978-3-319-13150-4_14

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-319-13150-4

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