Abstract
The long-term cure rates for Hodgkin lymphoma (HL) patients are above 80 % for all stages. Given this impressive long-term outcome for a patient population with a median age of about 30 years at diagnosis, the quality of survivorship has become more and more important. Organ dysfunctions including hypothyroidism, hypogonadism, cardiopulmonary complications, and secondary neoplasia as well as health-related quality of life (HRQoL) are major factors contributing to the patient’s general well-being.
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References
Ganz PA, Moinpour CM, Pauler DK et al (2003) Health status and quality of life in patients with early-stage Hodgkin’s disease treated on Southwest oncology group study 9133. J Clin Oncol 21:3512–3519
Heutte N, Flechtner HH, Mounier N et al (2009) Quality of life after successful treatment of early-stage Hodgkin’s lymphoma: 10-year follow-up of the EORTC-GELA H8 randomised controlled trial. Lancet Oncol 10:1160–1170
U.S. Department of Health and Human Services Food and Drug Administration (2009) Guidance for industry. Patient-reported outcome measures: use in medical product development to support labeling claims
Aaronson NK, Ahmedzai S, Bergman B et al (1993) The European organization for research and treatment of cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365–376
Cella DF, Tulsky DS, Gray G et al (1993) The functional assessment of cancer therapy scale: development and validation of the general measure. J Clin Oncol 11:570–579
Flechtner H, Ruffer JU, Henry-Amar M et al (1998) Quality of life assessment in Hodgkin’s disease: a new comprehensive approach. First experiences from the EORTC/GELA and GHSG trials. EORTC lymphoma cooperative group. Groupe D’Etude des Lymphomes de L’Adulte and German Hodgkin Study Group. Ann Oncol 9(Suppl 5):S147–S154
Guyatt GH, Osoba D, Wu AW, Wyrwich KW, Norman GR (2002) Methods to explain the clinical significance of health status measures. Mayo Clin Proc 77:371–383
Bottomley A, Flechtner H, Efficace F et al (2005) Health related quality of life outcomes in cancer clinical trials. Eur J Cancer 41:1697–1709
Cremeens J, Eiser C, Blades M (2006) Characteristics of health-related self-report measures for children aged three to eight years: a review of the literature. Qual Life Res 15:739–754
Calaminus G, Doerffel W, Baust K, Teske C, Riepenhausen M, Brämswig J, Flechtner HH, Singer S, Hinz A, Schellong G (2014) Quality of life in long-term survivors following treatment for Hodgkin’s disease during childhood and adolescence in the German multicentre studies between 1978 and 2002. Support Care Cancer 22:1519–1529
Roper K, McDermott K, Cooley ME, Daley K, Fawcett J (2009) Health-related quality of life in adults with Hodgkin’s disease: the state of the science. Cancer Nurs 32:E1–E17; quiz E18–E19
Fobair P, Hoppe RT, Bloom J, Cox R, Varghese A, Spiegel D (1986) Psychosocial problems among survivors of Hodgkin’s disease. J Clin Oncol 4:805–814
Joly F, Henry-Amar M, Arveux P et al (1996) Late psychosocial sequelae in Hodgkin’s disease survivors: a French population-based case-control study. J Clin Oncol 14:2444–2453
Loge JH, Abrahamsen AF, Ekeberg O, Kaasa S (1999) Hodgkin’s disease survivors more fatigued than the general population. J Clin Oncol 17:253–261
Wettergren L, Bjorkholm M, Axdorph U, Bowling A, Langius-Eklof A (2003) Individual quality of life in long-term survivors of Hodgkin’s lymphoma – a comparative study. Qual Life Res 12:545–554
Wettergren L, Bjorkholm M, Axdorph U, Langius-Eklof A (2004) Determinants of health-related quality of life in long-term survivors of Hodgkin’s lymphoma. Qual Life Res 13:1369–1379
Wettergren L, Bjorkholm M, Langius-Eklof A (2005) Validation of an extended version of the SEIQoL-DW in a cohort of Hodgkin lymphoma survivors. Qual Life Res 14:2329–2333
Ruffer JU, Flechtner H, Tralls P et al (2003) Fatigue in long-term survivors of Hodgkin’s lymphoma; a report from the German Hodgkin Lymphoma Study Group (GHSG). Eur J Cancer 39:2179–2186
Holzner B, Kemmler G, Cella D et al (2004) Normative data for functional assessment of cancer therapy – general scale and its use for the interpretation of quality of life scores in cancer survivors. Acta Oncol 43:153–160
Hjermstad MJ, Oldervoll L, Fossa SD, Holte H, Jacobsen AB, Loge JH (2006) Quality of life in long-term Hodgkin’s disease survivors with chronic fatigue. Eur J Cancer 42:327–333
Borchmann P, Muller H, Brillant C et al (2010) Longitudinal evaluation of quality of life and fatigue in Hodgkin lymphoma patients. ASH Ann Meet Abstr 116:935
Behringer K, Muller H, Gorgen H et al (2013) Sexual quality of life in Hodgkin lymphoma: a longitudinal analysis by the German Hodgkin Study Group. Br J Cancer 108:49–57
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Halbsguth, T.V., Flechtner, HH. (2015). Quality of Life in Hodgkin Lymphoma. In: Engert, A., Younes, A. (eds) Hodgkin Lymphoma. Hematologic Malignancies. Springer, Cham. https://doi.org/10.1007/978-3-319-12505-3_23
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DOI: https://doi.org/10.1007/978-3-319-12505-3_23
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