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Neuromodulation for the Treatment of Drug-Resistant Epilepsy

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Epilepsy Towards the Next Decade

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

Surgical neuromodulation for epilepsy refers to procedures involving the electrical stimulation of cortical, diencephalic, cerebellar and peripheral targets (such as the vagus nerve). Stereotactic radiosurgery also provides a neuromodulatory approach, affecting the discharging behavior of epileptic neurons in absence of evident target necrosis. Cortical transections or Multiple Subpial Transections (MST) are a non-resective technique useful to treat epileptogenic foci located in eloquent cortex. Electrical stimulation, stereotactic radiosurgery, and MST are emerging procedures for the treatment of medically refractory epilepsy in patients not amenable to resective surgery due to inability to map the focus, presence of multiple epileptogenic foci and/or involvement of eloquent cortex. Radiosurgery can also be offered to patients ineligible for invasive surgery for a variety of medical contraindications.

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Authors and Affiliations

  1. Centro Diagnostico Italiano, via Saint Bon 20, Milano, Italy

    Pantaleo Romanelli MD

  2. Department of Neurosurgery, University of Messina, AOU Policlinico “G. Martino” via Consolare Valeria 1, 98125, Messina, Italy

    Alfredo Conti MD, PhD

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  1. Pantaleo Romanelli MD
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Correspondence to Pantaleo Romanelli MD .

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  1. DINOGMI, University of Genoa, Genova, Genova, Italy

    Pasquale Striano

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Romanelli, P., Conti, A. (2015). Neuromodulation for the Treatment of Drug-Resistant Epilepsy. In: Striano, P. (eds) Epilepsy Towards the Next Decade. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-12283-0_12

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