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Pathobiology and Optical Molecular Imaging of Calcific Aortic Valve Disease

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Cardiovascular Imaging

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Abstract

Calcific aortic valve disease (CAVD) is a major contributor to cardiovascular morbidity and mortality, and given its association with age, the prevalence of CAVD is expected to rise with an increase in worldwide life expectancy. Currently, no therapies exist for the treatment or prevention of CAVD. Much of our understanding of the progression of CAVD has originated from preclinical data using optical molecular imaging of animal models. Through these studies we now know that CAVD is an inflammatory disease with a fibrocalcific endpoint. In this chapter, we will review the preclinical molecular imaging data that have shaped our current understanding of CAVD, and we will discuss the future role that molecular imaging technologies may play in the clinical diagnosis and treatment of this disease.

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Authors and Affiliations

  1. Division of Cardiovascular Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School, 3 Blackfan St., Room 1736, Boston, MA, 02115, USA

    Joshua D. Hutcheson PhD & Elena Aikawa MD, PhD

  2. Division of Cardiovascular Medicine, Center for Excellence in Vascular Biology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02114, USA

    Elena Aikawa MD, PhD

Authors
  1. Joshua D. Hutcheson PhD
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  2. Elena Aikawa MD, PhD
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Correspondence to Elena Aikawa MD, PhD .

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Editors and Affiliations

  1. Cardiovascular Medicine, Brigham and Women’s Hospital Harvard Medical School, Boston, Massachusetts, USA

    Elena Aikawa

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Sources of Funding

Dr. Aikawa is supported by grants from the National Institute of Health (R01HL114805; R01HL109506) and Harvard Catalyst Reactor Program.

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© 2015 Springer International Publishing Switzerland

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Hutcheson, J.D., Aikawa, E. (2015). Pathobiology and Optical Molecular Imaging of Calcific Aortic Valve Disease. In: Aikawa, E. (eds) Cardiovascular Imaging. Springer, Cham. https://doi.org/10.1007/978-3-319-09268-3_9

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  • DOI: https://doi.org/10.1007/978-3-319-09268-3_9

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-319-09268-3

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