Skip to main content

Dementia

  • Chapter
  • First Online:
Neurological Disorders in the Arab World

Abstract

Dementia is increasingly recognized as a major public health challenge due to the aging of the populations in both the developed and the developing world. In 2005 it was estimated that there were 24 million people with dementia worldwide. This chapter reviews the data available on the incidence, prevalence, subtypes and risk factors of dementia in the Arab World, as well as on societal costs and psychosocial aspects of dementia. Studies on dementia among Arabs are limited, as almost half of the papers are on the Palestinian population living in Wadi Ara in Israel. The available studies show that the pattern of dementia among Arabs is not different from that in other parts of the world. The prevalence of dementia among Arabs varies from very low in Saudi Arabia and Tunisia to very high in Wadi Ara. Age is considered as a risk factor of dementia in Arab populations. Alzheimer’s disease is more common among females whereas vascular dementia is more common in males. Some vascular risk factors seem to contribute to the development of dementia in various Arab populations. Illiteracy and a low level of education have been shown to be risk factors of dementia in some Arab populations. Apolipoprotein E 4-allele was not considered as a risk factor for Alzheimer’s disease in Wadi Ara. The cost of dementia in the Arab World was estimated at US$ 6.6 billion in 2009. It is clear that there are significant opportunities for further research on dementia among Arabs.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Alzheimer A, Stelzmann RA, Schnitzlein HN, Murtagh FR. An English translation of Alzheimer’s 1907 paper, “Uber eine eigenartige Erkankung der Hirnrinde”. Clin Anat. 1995;8(6):429–31.

    Article  CAS  PubMed  Google Scholar 

  2. Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, et al. Global prevalence of dementia: a Delphi consensus study. Lancet. 2005;366(9503):2112–7.

    Article  PubMed Central  PubMed  Google Scholar 

  3. World Health Organization. World Health Report 2003-Shaping the future. Geneva: WHO; 2003.

    Google Scholar 

  4. Wimo A, Jonsson L, Winblad B. An estimate of the worldwide prevalence and direct costs of dementia in 2003. Dement Geriatr Cogn Disord. 2006;21(3):175–81.

    Article  CAS  PubMed  Google Scholar 

  5. Wimo A, Winblad B, Jönsson L. The worldwide societal costs of dementia: estimates for 2009. Alzheimers Dement. 2010;6(2):98–103.

    Article  PubMed  Google Scholar 

  6. Langa KM, Chernew ME, Kabeto MU, Herzog AR, Ofstedal MB, Willis RJ, et al. National estimates of the quantity and cost of informal caregiving for the elderly with dementia. J Gen Intern Med. 2001;16(11):770–8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Mirkin B. Population levels, Trends and Policies in the Arab Region: challenges and opportunities. Arab human development reports: research paper series. United Nations Development Programme, Regional Bureau for Arab States 2010.

    Google Scholar 

  8. Bowirrat A, Friedland RP, Farrer L, Baldwin C, Korczyn A. Genetic and environmental risk factors for Alzheimer’s disease in Israeli Arabs. J Mol Neurosci. 2002;19(1–2):239–45.

    Article  CAS  PubMed  Google Scholar 

  9. Bowirrat A, Treves TA, Friedland RP, Korczyn AD. Prevalence of Alzheimer’s type dementia in an elderly Arab population. Eur J Neurol. 2001;8(2):119–23.

    Article  CAS  PubMed  Google Scholar 

  10. Bowirrat A, Friedland RP, Korczyn AD. Vascular dementia among elderly Arabs in Wadi Ara. J Neurol Sci. 2002;203–204:73–6.

    Article  PubMed  Google Scholar 

  11. Israeli-Korn SD, Masarwa M, Schechtman E, Abuful A, Strugatsky R, Avni S, et al. Hypertension increases the probability of Alzheimer’s disease and of mild cognitive impairment in an Arab community in northern Israel. Neuroepidemiology. 2010;34(2):99–105.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Afgin AE, Massarwa M, Schechtman E, Israeli-Korn SD, Strugatsky R, Abuful A, et al. High prevalence of mild cognitive impairment and Alzheimer’s disease in Arabic villages in northern Israel: impact of gender and education. J Alzheimers Dis. 2012;29(2):431–9.

    PubMed Central  PubMed  Google Scholar 

  13. Rahman TT, El Gaafary MM. Montreal Cognitive Assessment Arabic version: reliability and validity prevalence of mild cognitive impairment among elderly attending geriatric clubs in Cairo. Geriatr Gerontol Int. 2009;9(1):54–61.

    Article  PubMed  Google Scholar 

  14. Farrag A, Farwiz HM, Khedr EH, Mahfouz RM, Omran SM. Prevalence of Alzheimer’s disease and other dementing disorders: Assiut-Upper Egypt study. Dement Geriatr Cogn Disord. 1998;9(6):323–8.

    Article  CAS  PubMed  Google Scholar 

  15. El Tallawy HN, Farghaly WM, Rageh TA, Shehata GA, Badry R, Metwally NA, et al. Door-to-door survey of major neurological disorders (project) in Al Quseir City, Red Sea Governorate, Egypt. Neuropsychiatr Dis Treat. 2013;9:767–71.

    PubMed Central  PubMed  Google Scholar 

  16. El Tallawy HN, Farghaly WM, Rageh TA, Shehata GA, Metwaly NA, Elftoh NA, et al. Epidemiology of major neurological disorders project in Al Kharga District, New Valley, Egypt. Neuroepidemiology. 2010;35(4):291–7.

    Article  PubMed  Google Scholar 

  17. Al-Rajeh S, Bademosi O, Ismail H, Awada A, Dawodu A, Al-Freihi H, et al. A community survey of neurological disorders in Saudi Arabia: the Thugbah study. Neuroepidemiology. 1993;12(3):164–78.

    Article  CAS  PubMed  Google Scholar 

  18. Attia Romdhane N, Ben Hamida M, Mrabet A, Larnaout A, Samoud S, Ben Hamda A, et al. Prevalence study of neurologic disorders in Kelibia (Tunisia). Neuroepidemiology. 1993;12(5):285–99.

    Article  CAS  PubMed  Google Scholar 

  19. Ghuloum S, Bener A, Abou-Saleh MT. Prevalence of mental disorders in adult population attending primary health care setting in Qatari population. J Pak Med Assoc. 2011;61(3):216–21.

    PubMed  Google Scholar 

  20. Ghubash R, El-Rufaie O, Zoubeidi T, Al-Shboul QM, Sabri SM. Profile of mental disorders among the elderly United Arab Emirates population: sociodemographic correlates. Int J Geriatr Psychiatry. 2004;19(4):344–51.

    Article  PubMed  Google Scholar 

  21. Al Sulaiti EM, Abdelnour S, Ramadan M. A study of dementia in home care patients in Qatar with the psychosocial burden on caregivers. Qatar Med J. 2008;17(1):42–5.

    Google Scholar 

  22. Chahine LM, Bijlsma A, Hospers AP, Chemali Z. Dementia and depression among nursing home residents in Lebanon: a pilot study. Int J Geriatr Psychiatry. 2007;22(4):283–5.

    Article  CAS  PubMed  Google Scholar 

  23. Ogunniyi A, Daif AK, Al-Rajeh S, AbdulJabbar M, Al-Tahan AR, Al-Bunyan M, et al. Dementia in Saudi Arabia: experience from a university hospital. Acta Neurol Scand. 1998;98(2):116–20.

    Article  CAS  PubMed  Google Scholar 

  24. Shelley BP, Al KJ. The spectrum of dementia: frequency, causes and clinical profile. A national referral hospital-based study in Oman. Dement Geriatr Cogn Disord. 2007;24(4):280–7.

    Article  PubMed  Google Scholar 

  25. Hamad AI, Ibrahim MA, Sulaiti EM. Dementia in Qatar. Saudi Med J. 2004;25(1):79–82.

    PubMed  Google Scholar 

  26. Shelley BP, Al-Khabouri J, Hussein SS, Raniga SB. Frontotemporal dementia in Oman: cognitive behavioural profile and neuroimaging characteristics; a prospective hospital-based study. J Neurol Sci. 2007;260(1–2):167–74.

    Article  PubMed  Google Scholar 

  27. Tadmouri GO. Genetic disorders. In: Nasir LS, Abdul-Haq AK, editors. Caring for Arab patients: a biopsychosocial approach. Oxford, New York: Radcliffe Publishing; 2008. p. 61–74.

    Google Scholar 

  28. Kalaria RN, Maestre GE, Arizaga R, Friedland RP, Galasko D, Hall K, et al. Alzheimer’s disease and vascular dementia in developing countries: prevalence, management, and risk factors. Lancet Neurol. 2008;7(9):812–26.

    Article  PubMed Central  PubMed  Google Scholar 

  29. Borenstein AR, Copenhaver CI, Mortimer JA. Early-life risk factors for Alzheimer disease. Alzheimer Dis Assoc Disord. 2006;20(1):63–72.

    Article  PubMed  Google Scholar 

  30. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science. 1993;261(5123):921–3.

    Article  CAS  PubMed  Google Scholar 

  31. Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, Joo SH, et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer’s disease. Neurology. 1993;43(8):1467–72.

    Article  CAS  PubMed  Google Scholar 

  32. Bowirrat A, Friedland RP, Chapman J, Korczyn AD. The very high prevalence of AD in an Arab population is not explained by APOE epsilon4 allele frequency. Neurology. 2000;55(5):731.

    Article  CAS  PubMed  Google Scholar 

  33. Al-Khedhairy AAA. Apolipoprotein E polymorphism as a predictor for cognitive decline and dementia in the Saudi general population over 65 years. Genet Mol Biol. 2004;27(3):331–4.

    Article  CAS  Google Scholar 

  34. Rassas AA, Mrabet Khiari H, Hadj Fredj S, Sahnoun S, Batti H, Zakraoui NO, et al. High APOE epsilon 4 allele frequencies associated with Alzheimer disease in a Tunisian population. Neurol Sci. 2012;33(1):33–7.

    Article  PubMed  Google Scholar 

  35. Smach MA, Charfeddine B, Lammouchi T, Harrabi I, Ben Othman L, Dridi H, et al. CSF beta-amyloid 1–42 and tau in Tunisian patients with Alzheimer’s disease: the effect of APOE epsilon4 allele. Neurosci Lett. 2008;440(2):145–9.

    Article  CAS  PubMed  Google Scholar 

  36. Farrer LA, Friedland RP, Bowirrat A, Waraska K, Korczyn A, Baldwin CT. Genetic and environmental epidemiology of Alzheimer’s disease in Arabs residing in Israel. J Mol Neurosci. 2003;20(3):207–12.

    Article  CAS  PubMed  Google Scholar 

  37. Farrer LA, Bowirrat A, Friedland RP, Waraska K, Korczyn AD, Baldwin CT. Identification of multiple loci for Alzheimer disease in a consanguineous Israeli-Arab community. Hum Mol Genet. 2003;12(4):415–22.

    Article  CAS  PubMed  Google Scholar 

  38. Graves AB. Alzheimer’s disease and vascular dementia. In: Nelson LM, Tanner CM, Van Den Eeden SK, McGuire VM, editors. Neuroepidemiology. Oxford: Oxford University Press; 2004. p. 102–30.

    Google Scholar 

  39. Bowirrat A, Cui J, Waraska K, Friedland RP, Oscar-Berman M, Farrer LA, et al. Lack of association between angiotensin-converting enzyme and dementia of the Alzheimer’s type in an elderly Arab population in Wadi Ara, Israel. Neuropsychiatr Dis Treat. 2005;1(1):73–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  40. Mizrahi EH, Bowirrat A, Jacobsen DW, Korczyn AD, Traore F, Petot GJ, et al. Plasma homocysteine, vitamin B12 and folate in Alzheimer’s patients and healthy Arabs in Israel. J Neurol Sci. 2004;227(1):109–13.

    Article  CAS  PubMed  Google Scholar 

  41. Israeli-Korn SD, Massarwa M, Schechtman E, Strugatsky R, Avni S, Farrer LA, et al. Mild cognitive impairment is associated with mild parkinsonian signs in a door-to-door study. J Alzheimers Dis. 2010;22(3):1005–13.

    PubMed Central  PubMed  Google Scholar 

  42. Inzelberg R, Afgin AE, Massarwa M, Schechtman E, Israeli-Korn SD, Strugatsky R, et al. Prayer at midlife is associated with reduced risk of cognitive decline in Arabic women. Curr Alzheimer Res. 2013;10(3):340–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  43. Cohen M, Werner P, Azaiza F. Emotional reactions of Arab lay persons to a person with Alzheimer’s disease. Aging Ment Health. 2009;13(1):31–7.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Benamer, H.T.S. (2014). Dementia. In: Neurological Disorders in the Arab World. Springer, Cham. https://doi.org/10.1007/978-3-319-07257-9_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-07257-9_8

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-07256-2

  • Online ISBN: 978-3-319-07257-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics