Skip to main content

Pharmacological Treatment of Internet Addiction

  • Chapter
  • First Online:
Internet Addiction

Abstract

The increasing number of Internet users has resulted in an increased population percentage affected by the negative effects of problematic Internet usage. To date, the management of psychopathological Internet use is not supported by extensive empirical research. No standard clinical treatment protocols for pharmacological treatment exist, and as a result, empirical or anecdotal assessments based on case studies are mainly consulted. A relevant problem in performing clinical trials is the evolving nosology, which encompasses ambiguous definitions of Internet addiction and a diversity of diagnostic, prognostic, and therapeutic criteria. The aim of this chapter is to review the current literature, to assess the extent to which specific pharmacological interventions (e.g., using antidepressants, mood stabilizers, opioid receptor antagonists, or antipsychotics) can alleviate the symptomatic burden in patients with “Internet addiction.” We also explore pharmacological interventions that target patterns of comorbidity and underlying psychopathological dimensions (e.g., addiction, impulsivity, obsessive-compulsive spectrum, bipolar spectrum, dissociation, etc.) shared with other behavioral or substance addictions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    Characterizing a particular form of IA, namely “online game addiction”.

  2. 2.

    A clinical trial where both physician and patient know about the administered drug.

References

  • American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Association, Washington, DC

    Book  Google Scholar 

  • Atmaca M (2007) A case of problematic internet use successfully treated with an SSRI-antipsychotic combination. Prog Neuro-psychopharmacol Biol Psychiatry 31:961–962

    Article  Google Scholar 

  • Balodis IM, Kober H, Worhunsky PD et al (2012) Diminished frontostriatal activity during processing of monetary rewards and losses in pathological gambling. Biol Psychiatry 71:749–757

    Article  Google Scholar 

  • Bernardi S, Pallanti S (2009) Internet addiction: a descriptive clinical study focusing on comorbidities and dissociative symptoms. Compr Psychiatry 50:510–516

    Article  Google Scholar 

  • Bloch MH, Landeros-Weisenberger A, Kelmendi B et al (2006) A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorder. Mol psychiatry 11:622–632

    Article  Google Scholar 

  • Blum K, Gardner E, Oscar-Berman M, Gold M (2012) “Liking” and “wanting” linked to reward deficiency syndrome (RDS): hypothesizing differential responsivity in brain reward circuitry. Curr Pharm Des 18:113–118

    Article  Google Scholar 

  • Bostwick JM, Bucci JA (2008) Internet sex addiction treated with naltrexone. Mayo Clin Proc 83:226–230

    Article  Google Scholar 

  • Bystritsky A, Ackerman DL, Rosen RM et al (2004) Augmentation of serotonin reuptake inhibitors in refractory obsessive-compulsive disorder using adjunctive olanzapine: a placebo-controlled trial. J Clin Psychiatry 65:565–568

    Article  Google Scholar 

  • Camardese G, De Risio L, Di Nicola M et al (2012) A role for pharmacotherapy in the treatment of “internet addiction”. Clin Neuropharmacol 35:283–289

    Article  Google Scholar 

  • Choi YJ (2009) Efficacy of treatments for patients with obsessive-compulsive disorder: a systematic review. J Am Acad Nurse Pract 21:207–213

    Article  Google Scholar 

  • Christensen RC (2004) Olanzapine augmentation of fluoxetine in the treatment of pathological skin picking. Can J Psychiatry 49:788–789

    Google Scholar 

  • Connor KM, Payne VM, Gadde KM et al (2005) The use of aripiprazole in obsessive-compulsive disorder: preliminary observations in 8 patients. J Clin Psychiatry 66:49–51

    Article  Google Scholar 

  • Coric V, Kelmendi B, Pittenger C et al (2007) Beneficial effects of the antiglutamatergic agent riluzole in a patient diagnosed with trichotillomania. J Clin Psychiatry 68:170

    Article  Google Scholar 

  • Davis RA (2001) A cognitive-behavioral model of pathological internet use. Comput Hum Behav 17:187–195

    Article  Google Scholar 

  • de Ruiter MB, Veltman DJ, Goudriaan AE et al (2009) Response perseveration and ventral prefrontal sensitivity to reward and punishment in male problem gamblers and smokers. Neuropsychopharmacology 34:1027–1038

    Article  Google Scholar 

  • Dell’Osso B, Hadley S, Allen A et al (2008) Escitalopram in the treatment of impulsive-compulsive internet usage disorder: an open-label trial followed by a double-blind discontinuation phase. J Clin Psychiatry 69:452–456

    Article  Google Scholar 

  • Denys D, de Geus F, van Megen HJ, Westenberg HG (2004) A double-blind, randomized, placebo-controlled trial of quetiapine addition in patients with obsessive-compulsive disorder refractory to serotonin reuptake inhibitors. J Clin Psychiatry 65:1040–1048

    Article  Google Scholar 

  • Di Chiara G, Bassareo V (2007) Reward system and addiction: what dopamine does and doesn’t do. Curr Opin Pharmacol 7:69–76

    Article  Google Scholar 

  • Di Chiara G, North RA (1992) Neurobiology of opiate abuse. Trends Pharmacol Sci 13:185–193

    Article  Google Scholar 

  • Di Nicola M, Martinotti G, Mazza M et al (2010a) Quetiapine as add-on treatment for bipolar I disorder with comorbid compulsive buying and physical exercise addiction. Prog Neuropsychopharmacol Biol Psychiatry 34:713–714

    Article  Google Scholar 

  • Di Nicola M, Tedeschi D, Mazza M et al (2010b) Behavioural addictions in bipolar disorder patients: role of impulsivity and personality dimensions. J Affect Disord 125:82–88

    Article  Google Scholar 

  • Evans SM, Levin FR, Brooks DJ, Garawi F (2007) A pilot double-blind treatment trial of memantine for alcohol dependence. Alcohol Clin Exp Res 31:775–782

    Article  Google Scholar 

  • Garnis-Jones S, Collins S, Rosenthal D (2000) Treatment of self-mutilation with olanzapine. J Cutan Med Surg 4:161–163

    Google Scholar 

  • Goddard AW, Shekhar A, Whiteman AF, McDougle CJ (2008) Serotoninergic mechanisms in the treatment of obsessive-compulsive disorder. Drug Discov Today 13:325–332

    Article  Google Scholar 

  • Goldberg JF, Whiteside JE (2002) The association between substance abuse and antidepressant-induced mania in bipolar disorder: a preliminary study. J Clin Psychiatry 63:791–795

    Article  Google Scholar 

  • Grant JE, Kim SW, Hollander E, Potenza MN (2008) Predicting response to opiate antagonists and placebo in the treatment of pathological gambling. Psychopharmacology 200:521–527

    Article  Google Scholar 

  • Grant JE, Kim SW, Odlaug BL (2009) A double-blind, placebo-controlled study of the opiate antagonist, naltrexone, in the treatment of kleptomania. Biol Psychiatry 65:600–606

    Article  Google Scholar 

  • Grant JE, Chamberlain SR, Odlaug BL et al (2010a) Memantine shows promise in reducing gambling severity and cognitive inflexibility in pathological gambling: a pilot study. Psychopharmacology 212:603–612

    Article  Google Scholar 

  • Grant P, Song JY, Swedo SE (2010b) Review of the use of the glutamate antagonist riluzole in psychiatric disorders and a description of recent use in childhood obsessive-compulsive disorder. J Child Adolesc Psychopharmacol 20:309–315

    Article  Google Scholar 

  • Griffiths M (2000) Does internet and computer “addiction” exist? Some case study evidence. CyberPsychol Behav 3:211–218

    Article  Google Scholar 

  • Guglielmo R, Martinotti G, Clerici M, Janiri L (2012) Pregabalin for alcohol dependence: a critical review of the literature. Adv Ther 29:947–957

    Article  Google Scholar 

  • Han DH, Lee YS, Na C et al (2009) The effect of methylphenidate on internet video game play in children with attention-deficit/hyperactivity disorder. Compr Psychiatry 50:251–256

    Article  Google Scholar 

  • Han DH, Hwang JW, Renshaw PF (2010) Bupropion sustained release treatment decreases craving for video games and cue-induced brain activity in patients with internet video game addiction. Exp Clin Psychopharmacol 18:297–304

    Article  Google Scholar 

  • Han DH, Renshaw PF (2011) Bupropion in the treatment of problematic online game play in patients with major depressive disorder. J Psychopharmacol 26:689–696

    Article  Google Scholar 

  • Hollander E, Rossi NB, Sood E, Pallanti S (2003) Risperidone augmentation in treatment-resistant obsessive-compulsive disorder: a double-blind, placebo-controlled study. Int J Neuropsychopharmacol 6:397–401

    Article  Google Scholar 

  • Hughes JR, Stead LF, Lancaster T (2007) Antidepressants for smoking cessation. Cochrane Database Syst Rev CD000031

    Google Scholar 

  • Janiri L, Hadjichristos A, Buonanno A et al (1998) Adjuvant trazodone in the treatment of alcoholism: an open study. Alcohol Alcohol 33:362–365

    Article  Google Scholar 

  • Kim SW, Grant JE, Grosz RL (2002) Pathological gambling. Current status and new treatments. Minn Med 85:48–50

    Google Scholar 

  • King DL, Delfabbro PH, Griffiths MD, Gradisar M (2011) Assessing clinical trials of Internet addiction treatment: a systematic review and CONSORT evaluation. Clin Psychol Rev 31:1110–1116

    Article  Google Scholar 

  • Ko CH, Liu GC, Hsiao S et al (2009) Brain activities associated with gaming urge of online gaming addiction. J Psychiatr Res 43:739–747

    Article  Google Scholar 

  • Kollins SH, Jain R, Brams M et al (2011) Clonidine extended-release tablets as add-on therapy to psychostimulants in children and adolescents with ADHD. Pediatrics 127:e1406–e1413

    Article  Google Scholar 

  • Koran LM, Bullock KD, Hartston HJ et al (2002) Citalopram treatment of compulsive shopping: an open-label study. J Clin Psychiatry 63:704–708

    Article  Google Scholar 

  • Koran LM, Aboujaoude EN, Gamel NN (2007) Escitalopram treatment of kleptomania: an open-label trial followed by double-blind discontinuation. J Clin Psychiatry 68:422–427

    Article  Google Scholar 

  • Krystal JH, Petrakis IL, Krupitsky E et al (2003) NMDA receptor antagonism and the ethanol intoxication signal: from alcoholism risk to pharmacotherapy. Ann NY Acad Sci 1003:176–184

    Article  Google Scholar 

  • Lee YS, Han DH, Yang KC et al (2008) Depression like characteristics of 5HTTLPR polymorphism and temperament in excessive internet users. J Affect Disord 109:165–169

    Article  Google Scholar 

  • Liu J, Gao XP, Osunde I et al (2010) Increased regional homogeneity in internet addiction disorder: a resting state functional magnetic resonance imaging study. Chin Med J 123:1904–1908

    Google Scholar 

  • Maina G, Pessina E, Albert U, Bogetto F (2008) 8-week, single-blind, randomized trial comparing risperidone versus olanzapine augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder. Eur Neuropsychopharmacol 18:364–372

    Article  Google Scholar 

  • Maremmani I, Pacini M, Lamanna F et al (2010) Mood stabilizers in the treatment of substance use disorders. Int J Neuropsychiatric Med 15:95–109

    Google Scholar 

  • Martinotti G, Di Nicola M, Janiri L (2007) Efficacy and safety of aripiprazole in alcohol dependence. Am J Drug Alcohol Abuse 33:393–401

    Article  Google Scholar 

  • Martinotti G, Di Nicola M, Di Giannantonio M, Janiri L (2009) Aripiprazole in the treatment of patients with alcohol dependence: a double-blind, comparison trial vs. naltrexone. J Psychopharmacol 23:123–129

    Article  Google Scholar 

  • McElroy SL, Nelson EB, Welge JA et al (2008) Olanzapine in the treatment of pathological gambling: a negative randomized placebo-controlled trial. J Clin Psychiatry 69:433–440

    Article  Google Scholar 

  • Muir VJ, Perry CM (2010) Guanfacine extended-release: in attention deficit hyperactivity disorder. Drugs 70:1693–1702

    Article  Google Scholar 

  • Pallanti S, Quercioli L, Sood E, Hollander E (2002) Lithium and valproate treatment of pathological gambling: a randomized single-blind study. J Clin Psychiatry 63:559–564

    Article  Google Scholar 

  • Petry NM, O’Brien CP (2013) Internet gaming disorder and the DSM-5. Addiction 108:1186–1187

    Article  Google Scholar 

  • Pittenger C, Krystal JH, Coric V (2005) Initial evidence of the beneficial effects of glutamate-modulating agents in the treatment of self-injurious behavior associated with borderline personality disorder. J Clin Psychiatry 66:1492

    Article  Google Scholar 

  • Reuter J, Raedler T, Rose M, Hand I, Glascher J, Buchel C (2005) Pathological gambling is linked to reduced activation of the mesolimbic reward system. Nat Neurosci 8:147–148

    Article  Google Scholar 

  • Roncero C, Rodriguez-Urrutia A, Grau-Lopez L, Casas M (2009) Antiepileptic drugs in the control of the impulses disorders. Actas Esp Psiquiatr 37:205–212

    Google Scholar 

  • Sasso DA, Kalanithi PS, Trueblood KV et al (2006) Beneficial effects of the glutamate-modulating agent riluzole on disordered eating and pathological skin-picking behaviors. J Clin Psychopharmacol 26:685–697

    Article  Google Scholar 

  • Sattar P, Ramaswamy S (2004) Internet gaming addiction. Can J Psychiatry 49:869–870

    Google Scholar 

  • Shapira NA, Goldsmith TD, Keck PE et al (2000) Psychiatric features of individuals with problematic internet use. J Affect Disord 57:267–272

    Article  Google Scholar 

  • Shapira NA, Lessig MC, Goldsmith TD et al (2003) Problematic internet use: proposed classification and diagnostic criteria. Depress Anxiety 17:207–216

    Article  Google Scholar 

  • Shoja-Shafti S (2006) Treatment of borderline personality disorder with olanzapine. Arch Iran Med 9:403–405

    Google Scholar 

  • Stewart RS, Nejtek VA (2003) An open-label, flexible-dose study of olanzapine in the treatment of trichotillomania. J Clin Psychiatry 64:49–52

    Article  Google Scholar 

  • Tao R, Huang X, Wang J et al (2010) Proposed diagnostic criteria for internet addiction. Addiction 105:556–564

    Article  Google Scholar 

  • Weinstein A, Greif J, Yemini Z et al (2010) Attenuation of cue-induced smoking urges and brain reward activity in smokers treated successfully with bupropion. J Psychopharmacol 24:829–838

    Article  Google Scholar 

  • Weinstein A, Lejoyeux M (2010) Internet addiction or excessive internet use. Am J Drug Alcohol Abuse 36:277–283

    Article  Google Scholar 

  • WHO (2010) The ICD-10 classification of mental and behavioral disorders, 10th edn. World Health Organization, Geneva

    Google Scholar 

  • Winkler A, Dorsing B, Rief W et al (2013) Treatment of internet addiction: a meta-analysis. Clin Psychol Rev 33:317–329

    Article  Google Scholar 

  • Yen JY, Ko CH, Yen CF et al (2007) The comorbid psychiatric symptoms of Internet addiction: attention deficit and hyperactivity disorder (ADHD), depression, social phobia, and hostility. J Adolesc Health 41:93–98

    Article  Google Scholar 

  • Yoo HJ, Cho SC, Ha J et al (2004) Attention deficit hyperactivity symptoms and internet addiction. Psychiatry Clin Neurosci 58:487–494

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Giovanni Camardese .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Camardese, G., Leone, B., Walstra, C., Janiri, L., Guglielmo, R. (2015). Pharmacological Treatment of Internet Addiction. In: Montag, C., Reuter, M. (eds) Internet Addiction. Studies in Neuroscience, Psychology and Behavioral Economics. Springer, Cham. https://doi.org/10.1007/978-3-319-07242-5_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-07242-5_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-07241-8

  • Online ISBN: 978-3-319-07242-5

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics