Abstract
Both cartilage and muscle mass are affected by the advent of the menopause transition and the effect of hypoestrogenism. For a while it was thought that bone only was affected in this way, but infact all connective tissues systems are affected similarly. There is now growing evidence that cartilage (another connective tissue system) is similarly affected. After the menopause, overall intervertebral disc height is reduced in menopausal women. Muscle bulk is similarly affected by the menopause, with a decline in muscle mass and strength occuring after the menopause.
There is now an ever growing body of evidence that the menopause introduces a non-age-dependent variable in all forms of connective tissue loss and even muscle bulk and power. With hormone replacement therapy, this loss is limited and in some cases replaced. This highlights the importance of continuing work or the effect of oestrogen deprivation and its replacement and the multisystemic properties of this important class of hormones.
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References
Takahashi M, Kushida K, Hoshino H, Ohishi T, Inoue T (1999) Biochemical markers of bone turnover do not decline after menopause in healthy women. Br J Obstet Gynaecol 106(5):427–431
Bland R (2000) Steroid hormone receptor expression and action in bone. Clin Sci (Lond) 98(2):217–240
Barengolts EI, Gajardo HF, Rosol TJ, D’Anza JJ, Pena M, Botsis J, Kukreja SC (1990) Effects of progesterone on postovariectomy bone loss in aged rats. J Bone Miner Res 5(11):1143–1147
Bowman BM, Miller SC (1996) Elevated progesterone during pseudopregnancy may prevent bone loss associated with low estrogen. J Bone Miner Res 11(1):15–21
Fujimaki T, Kurabayashi T, Yamamoto Y, Yasuda M, Tojo Y, Yahata T, Tanaka K (1995) Effects of progesterone on the metabolism of cancellous bone in young oophorectomized rats. J Obstet Gynaecol 21(1):31–36
Liang M, Liao EY, Xu X, Luo XH, Xiao XH (2003) Effects of progesterone and 18-methyl levonorgestrel on osteoblastic cells. Endocr Res 29(4):483–501
Ikram Z, Dulipsingh L, Prestwood KM (1999) Lack of effect of short-term micronized progesterone on bone turnover in postmenopausal women. J Womens Health Gend Based Med 8(7):973–978
Moskowitz D (2006) A comprehensive review of the safety and efficacy of bioidentical hormones for the management of menopause and related health risks. Altern Med Rev 11(3):208–223
Burnett CC, Reddi AH (1983) Influence of estrogen and progesterone on matrix-induced endochondral bone formation. Calcif Tissue Int 35(4–5):609–614
Schmidt IU, Wakley GK, Turner RT (2000) Effects of estrogen and progesterone on tibia histomorphometry in growing rats. Calcif Tissue Int 67(1):47–52
Yamamoto Y, Kurabayashi T, Tojo Y, Yahata T, Honda A, Tomita M, Tanaka K (1998) Effects of progestins on the metabolism of cancellous bone in aged oophorectomized rats. Bone 22(5):533–537
Brincat MP, Baron YM, Galea R (2007a) Connective tissue changes in the menopause and with HRT. In: R. A. Lobo (ed) Treatment of the postmenopausal woman: basic and clinical aspects. Academic, London
Boos N, Weissbach S, Rohrbach H, Weiler C, Spratt KF, Nerlich AG (2002) Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine 27(23):2631–2644
Baron YM, Brincat MP, Galea R, Calleja N (2005) Intervertebral disc height in treated and untreated overweight post-menopausal women. Hum Reprod 20(12):3566–3570
Brincat MP, Calleja-Agius J, Baron YM (2007) The skin, carotid and intervertebral disc: making the connection! Climacteric 10(Suppl 2):83–87
Muscat BY, Brincat MP, Galea R, Calleja N (2007) Low intervertebral disc height in postmenopausal women with osteoporotic vertebral fractures compared to hormone-treated and untreated postmenopausal women and premenopausal women without fractures. Climacteric 10(4):314–319
Gambacciani M, Pepe A, Cappagli B, Palmieri E, Genazzani AR (2007) The relative contributions of menopause and aging to postmenopausal reduction in intervertebral disk height. Climacteric 10(4):298–305
Lowe DA, Baltgalvis KA, Greising SM (2010) Mechanisms behind estrogen’s beneficial effect on muscle strength in females. Exerc Sport Sci Rev 38(2):61–67
Dieli-Conwright CM, Spektor TM, Rice JC, Sattler FR, Schroeder ET (2010) Hormone replacement therapy and messenger RNA expression of estrogen receptor coregulators after exercise in postmenopausal women. Med Sci Sports Exerc 42(3):422–429
Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H, Bonds D, Brunner R, Brzyski R, Caan B, Chlebowski R, Curb D, Gass M, Hays J, Heiss G, Hendrix S, Howard BV, Hsia J, Hubbell A, Jackson R, Johnson KC, Judd H, Kotchen JM, Kuller L, LaCroix AZ, Lane D, Langer RD, Lasser N, Lewis CE, Manson J, Margolis K, Ockene J, O’Sullivan MJ, Phillips L, Prentice RL, Ritenbaugh C, Robbins J, Rossouw JE, Sarto G, Stefanick ML, Van Horn L, Wactawski-Wende J, Wallace R, Wassertheil-Smoller S (2004) Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. JAMA 291(14):1701–1712
Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA 288(3):321–333
Hays J, Hunt JR, Hubbell FA, Anderson GL, Limacher M, Allen C, Rossouw JE (2003) The Women’s Health Initiative recruitment methods and results. Ann Epidemiol 13(9 Suppl):S18–S77
MacLennan AH (2007) HRT: a reappraisal of the risks and benefits. Med J Aust 186(12):643–646
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Calleja-Agius, J., Brincat, M. (2014). Menopause-Related Changes in the Musculoskeletal System, Cartilages and Joints. In: Genazzani, A.R., Brincat, M. (eds) Frontiers in Gynecological Endocrinology. ISGE Series. Springer, Cham. https://doi.org/10.1007/978-3-319-03494-2_19
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DOI: https://doi.org/10.1007/978-3-319-03494-2_19
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