Abstract
ASD is a behaviorally defined neurodevelopmental disorder. As the term spectrum implies, it refers to a heterogeneous group of phenotypes with a range of neurobiologic features. Some cases occur in other medical conditions such as Fragile X syndrome; in such instances, medical comorbidities are usually seen as part of the underlying medical disorder.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Coury DL. Medical treatment of autism spectrum disorders. Curr Opin Neurol. 2010;23:131-136.
Campbell DB1, Buie TM, Winter H, Bauman M, Sutcliffe JS, Perrin JM, Levitt P. Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions. Pediatrics. 2009;123:1018-1024.
Minshew, NJ, Sweeney JA, Bauman ML. Neurologic aspects of autism. In, Cohen DJ, Volkmar FR, eds. Handbook of Autism and Pervasive Developmental Disorders. 2nd edn. New York, New York: Wiley; 1997.
Tuchman R, Hirtz D, Mamounas LA. NINDS epilepsy and autism spectrum disorders workshop report. Neurology 2013;81;1630-1636.
Amiet C, Gourfinkel-An I, Bouzamondo A, et al. Epilepsy in autism is associated with intellectual disability and gender: evidence from a meta-analysis. Biol Psychiatry. 2008;64:577-582.
Giovedi S, Corradi A, Fassio A, Benfenati F. Involvement of synaptic genes in the pathogenesis of autism spectrum disorders: the case of synapsins. Front Pediatr. 2014;2:94.
Kagan-Kushnir T, Roberts SW, Snead 3rd OC. Screening electroencephalograms in autism spectrum disorders: evidence based guideline. J Child Neurol. 2005;20:197-206.
Valicenti-McDermott M, McVicar K, Rapin I, Wershil BK, Cohen H, Shinnar S. Frequency of gastrointestinal symptoms in children with autistic spectrum disorders and association with family history of autoimmune disease. J Dev Behav Pediatrics. 2006; 27;S128-S136.
Wakefield AJ, Murch SH, Anthony A, et al. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet. 1998;35:637-641. Retraction in: Lancet. 2010;375:445. Partial retraction in: Murch SH, Anthony A, Casson DH, Malik M, et al. Lancet. 2004;363:750.
Carbone PS, Behl DD, Azor V, Murphy NA. The medical home for children with autism spectrum disorders: parent and pediatrician perspectives. J Autism Dev Disord. 2010;40:317-324.
Buie T, Fuchs GJ 3rd, Furuta GT, et al. Recommendations for evaluation and treatment of common gastrointestinal problems in children with ASDs. Pediatrics. 2010;125(suppl 1):S19-S29.
Lehwald N, Krausch M, Franke C, Assmann B, Adam R, Knoefel WT. Sandifer syndrome—a multidisciplinary diagnostic and therapeutic challenge. Eur J Pediatr Surg. 2007;17:203-206.
Williams BL, Hornig M, Buie T, et al. Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances. PLoS One. 2011;6:e24585.
Porter AE, Glaze DG. Sleep Problems. In, Amaral D, Dawson G, Geschwind D, eds, Autism Spectrum Disorders. Oxford, UK: Oxford University Press; 2011.
Kotagal S, Broomall E. Sleep in children with autism spectrum disorder. Pediatr Neurol. 2012;47:242-225.
American Academy of Sleep Medicine. International Classification of Sleep Disorders, Diagnostic and Coding Manual. 2nd edn. Westchester, IL: American Academy of Sleep Medicine; 2005.
Malow BA, Byars K, Johnson K, et al. A practice pathway for the identification, evaluation, and management of insomnia in children and adolescents with autism spectrum disorders. Pediatrics. 2012;130:S106-S124.
Malow BA, Adkins KW, Reynolds A, etal T. Parent-based sleep education for children with autism spectrum disorders. J Autism Dev Disord. 2014;44:216-228.
Malow B, Adkins KW, McGrew SG, et al. Melatonin for sleep in children with autism: a controlled trial examining dose, tolerability, and outcomes. J Autism Dev Disord. 2012;42:1729-1737.
Amos LB, Grekowicz ML, Kuhn EM, et al. Treatment of pediatric restless legs syndrome. Clin Pediatr (Phila). 2014;53:331-336.
Geschwind D. Commentary: autism genetics and genomics: a brief overview and synthesis. In, Amaral D, Dawson G, Geschwind D, eds. Autism Spectrum Disorders. Oxford, UK : Oxford University Press; 2011.
Sebat J, Lakshmi B, Malhotra D, et al. Strong association of de novo copy number mutations with autism. Science. 2007;316 :445-449.
Klei L, Sanders SJ, Murtha MT, et al. Common genetic variants, acting additively, are a major source of risk for autism. Mol Autism. 2012;3:9.
Johnson CP, Myers SM. Identification and evaluation of children with autism spectrum disorders. Pediatrics. 2007;120:1183-1215.
Persico AM, Napolioni V. Autism genetics. Behav Brain Res. 2013 251:95-112.
Miller DT, Adam MP, Aradhya S, Biesecker LG, et al. Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies. Am J Hum Genet. 2010;86:749-764.
Campbell DB, Buie TM, Winter H, et al. Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions. Pediatrics. 2009;123:1018-1024.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Walton, J.R., Coury, D.L. (2015). Medical comorbidities in autism spectrum disorder. In: Anagnostou, E., Brian, J. (eds) Clinician’s Manual on Autism Spectrum Disorder. Adis, Cham. https://doi.org/10.1007/978-3-319-03056-2_4
Download citation
DOI: https://doi.org/10.1007/978-3-319-03056-2_4
Published:
Publisher Name: Adis, Cham
Print ISBN: 978-3-319-03055-5
Online ISBN: 978-3-319-03056-2
eBook Packages: MedicineMedicine (R0)