Abstract
Neuronal outputs are complex signals of dynamically integrated excitatory and inhibitory components. Decreased synaptic inhibition in a neuronal network increases excitability and multiple spiking in neurons. Synchronized multiple spiking among a neuronal population further generates rhythmic field potentials and this epileptiform activity can propagate in the brain and cause seizures. Pharmacological interventions that reduce rhythmicity of epileptiform activity may have antiepileptic potentials. We evaluated the Lempel-Ziv (LZ) complexity for identifying rhythmicity in population spikes recorded in granule cells of the murine dentate gyrus in vitro. Blocking synaptic inhibition by the GABA A receptor antagonist, bicuculline, caused epileptiform population spikes, and we found that the LZ complexity of the signal was significantly reduced. Moreover, the GABA B receptor agonist, baclofen, reduced the amplitude of the epileptiform population spike and we found that it increased LZ complexity. The results show that LZ complexity is sensitive to pharmacological interventions that apparently alter rhythmicity of neuronal outputs by desynchronizing neuronal population firing. This novel approach in neuronal signal processing may be used to identify new antiepileptic targets.
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© 2014 Springer International Publishing Switzerland
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Abásolo, D., González, L., Chen, Y. (2014). Complexity of Epileptiform Activity in a Neuronal Network and Pharmacological Intervention. In: Roa Romero, L. (eds) XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013. IFMBE Proceedings, vol 41. Springer, Cham. https://doi.org/10.1007/978-3-319-00846-2_142
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DOI: https://doi.org/10.1007/978-3-319-00846-2_142
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-00845-5
Online ISBN: 978-3-319-00846-2
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