Zusammenfassung
Erkrankungen des Innenohres wie die Altersschwerhörigkeit, der peripher-vestibuläre Schwindel und Tinnitus sind weit verbreitet. Eine kausale Therapiemöglichkeit besteht jedoch auch heute noch nicht. Vielmehr führen wir eine empirische rheologisch-antiphlogistische Therapie durch, deren Kostenerstattung inzwischen unter Druck geraten ist. Gerade der demographische Wandel führt mit größter Wahrscheinlichkeit zu einem erheblichen Anstieg der Zahl Betroffener. So wird die Zahl der über 80-jährigen Mitmenschen in Deutschland bis 2025 um 70 % zunehmen (Bertelsmann-Stiftung). Bis 2035 soll jeder dritte Deutsche älter als 65 Jahre alt sein (Statistisches Bundesamt). Dies bedeutet, dass bis zu diesem Zeitpunkt geschätzte 10,4 Mio. Menschen über 65 Jahren durch ihren Hörverlust in der Kommunikation und damit in ihrer Fähigkeit zur Teilnahme am Leben beeinträchtigt sein werden.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Bedrosian JC, Gratton MA, Brigande JV et al. (2006) In vivo delivery of recombinant viruses to the fetal murine cochlea: transduction characteristics and long-term effects on auditory function Mol.Ther. 14: 328–335
Brozoski TJ, Ciobanu L, Bauer CA (23-2-2007) Central neural activity in rats with tinnitus evaluated with manganese-enhanced magnetic resonance imaging (MEMRI) Hear. Res.
Cantos R, Lopez DE, Sala ML, et al. (2000) Study of the olivocochlear neurons using two different tracers, fast blue and cholera toxin, in hypothyroid rats Anat. Embryol. (Berl). 201: 245–257
Chirmule N, Propert K, Magosin S, et al. (1999) Immune responses to adenovirus and adeno-associated virus in humans Gene Ther. 6: 1574–1583
Derby ML, Sena-Esteves M, Breakefeld XO, et al. (1999) Gene transfer into the mammalian inner ear using HSV-1 and vaccinia virus vectors Hear.Res. 134: 1–8
Ernfors P, Duan ML, ElShamy WM, et al. (1996) Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3 Nat Med 2: 463–467
Fisher KD, Stallwood Y, Green NK, et al. (2001) Polymer-coated adenovirus permitseffcient retargeting and evades neutralising antibodies Gene Ther. 8: 341–348
Forge A, Li L, Corwin JT, et al. (12-3-1993) Ultrastructural evidence for hair cell regeneration in the mammalian inner ear Science. 259: 1616–1619
Ghirotti M, Semproni G, De Meneghi D, et al. (1991) Sero-prevalences of selected cattle diseases in the Kafue flats of ZambiaVet. Res. Commun. 15: 25–36
Gleich O, Hamann I, Klump GM, et al. (6-10-2003) Boosting GABA improves impaired auditory temporal resolution in the gerbil Neuroreport. 14: 1877–1880
Gray LE Jr, Rogers JM, Ostby JS, et al. (1988) Prenatal dinocap exposure alters swimming behavior in mice due to complete otolith agenesis in the inner ear Toxicol. Appl.Pharmacol. 92: 266–273
Han D, Yu Z, Fan E, et al. (2004) Morphology of auditory hair cells in guinea pig cochlea after transgene expression Hear.Res. 190: 25–30
Henkel CK, Gabriele ML (1999) Organization of the disynaptic pathway from the anteroventral cochlear nucleus to the lateral superior olivary nucleus in the ferret Anat. Embryol. (Berl). 199: 149–160
Hill SL III, Digges EN, Silverstein H (2006) Long-term follow-up after gentamicin application via the Silverstein MicroWick in the treatment of Meniere’s disease Ear Nose Throat J. 85: 494, 496, 498
Hodges AV, Schloffman J, Balkany T (1997) Conservation of residual hearing with cochlear implantation Am.J.Otol. 18: 179–183
Imig TJ, Durham D (3-10-2005) Effect of unilateral noise exposure on the tonotopic distribution of spontaneous activity in the cochlear nucleus and inferior colliculus in the cortically intact and decorticate rat J.Comp Neurol. 490: 391–413
Izumikawa M, Minoda R, Kawamoto K, et al. (2005) Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals Nat.Med. 11: 271–276
Jero J, Mhatre AN, Tseng CJ, et al. (20-3-2001) Cochlear gene delivery through an intact round window membrane in mouse Hum. Gene Ther. 12: 539–548
Kaiser A, Fedrowitz M, Ebert U, et al. (2001) Auditory and vestibular defects in the circling (ci2) rat mutant Eur.J.Neurosci. 14: 1129–1142
Kanzaki S, Shiotani A, Inoue M, et al. (2007) Sendai virus vector-mediated transgene expression in the cochlea in vivo Audiol.Neuro-otol. 12: 119–126
Kawamoto K, Ishimoto S, Minoda R, et al. (2003) Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo J Neurosci. 23: 4395–4400
Kawamoto K, Oh SH, Kanzaki S, et al. (2001) The functional and structural outcome of inner ear gene transfer via the vestibular and cochlear fluids in mice Mol Ther. 4: 575–585
Keithley EM, Ma CL, Ryan AF, et al. (1998) GDNF protects the cochlea against noise damage Neuroreport. 9: 2183–2187
Kneuer C, Sameti M, Bakowsky U, et al. (2000a) A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro Bioconjug.Chem. 11: 926–932
Kneuer C, Sameti M, Haltner EG, et al. (2000b) Silica nanoparticles modifed with aminosilanes as carriers for plasmid DNAInt. J.Pharm. 196: 257–261
Kurokawa T, Saito H (1995) Retrograde axonal transport of different fluorescent tracers from the neocortex to the suprageniculate nucleus in the rat Hear.Res. 85: 103–108
Lambert PR (1994) Inner ear hair cell regeneration in a mammal: identification of a triggering factor Laryngoscope. 104: 701–718
Lim F, Hartley D, Starr P, et al. (1996) Generation of high-titer defective HSV-1 vectors using an IE 2 deletion mutant and quantitative study of expression in cultured cortical cells Biotechniques. 20: 460–469
Liu Y, Okada T, Sheykholeslami K, et al. (2005) Specific and efficient transduction of Cochlear inner hair cells with recombinant adeno-associated virus type 3 vector Mol. Ther. 12: 725–733
Marangos N, Illing RB, Kruger J, et al. (2001) In vivo visualization of the cochlear nerve and nuclei with fuorescent axonal tracers Hear. Res. 162: 48–52
Middlebrooks JC, Zook JM (1983) Intrinsic organization of the cat’s medial geniculate body identified by projections to binaural response-specific bands in the primary auditory cortex J.Neurosci. 3: 203–224
Padilla De Jesus OL, Ihre HR, Gagne L, et al. (2002) Polyester dendritic systems for drug delivery applications: in vitro and in vivo evaluation Bioconjug.Chem. 13: 453–461
Pau HW, Just T, Bornitz M, et al. (2007) Noise exposure of the inner ear during drilling a cochleostomy for cochlear implantation-Laryngoscope. 117: 535–540
Peterka RJ, Wall C III, Kentala E (2006) Determining the effectiveness of a vibrotactile balance prosthesis J.Vestib.Res. 16: 45–56
Plontke SK, Salt AN (2003) Quantitative interpretation of corticosteroid pharmacokinetics in inner fluids using computer simulations-Hear.Res. 182: 34–42
Praetorius M, Brunner C, Lehnert B, Klingmann C, Schmidt H, Staecker H, Schick B (2007) Transsynaptic delivery of nanoparticles to the central auditory nervous system. Acta Otolaryngol. 127(5): 486–489
Praetorius M, Baker K, Brough DE, Plinkert P, Staecker H (2007) Pharmacodynamics of adenovector distribution within the inner ear tissues of the mouse. Hear Res. 227(1–2): 53–80
Praetorius M, Baker K, Weich CM, et al. (2003) Hearing preservation after inner ear gene therapy: the effect of vector and surgical approachORL J.Otorhinolaryngol.Relat Spec. 65: 211–214
Praetorius M, Knipper M, Schick B, Tan J, Limberger A, Carnicero E, Alonso MT, Schimmang T (2002) A novel vestibular approach for gene transfer into the inner ear. Audiol Neurootol. 7(6): 324–334
Raper SE, Chirmule N, Lee FS, et al. (2003) Fatal systemic infammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer Mol.Genet.Metab. 80: 148–158
Rask-Andersen H, Schrott-Fischer A, Pfaller K, et al. (2006) Perilymph/modiolar communication routes in the human cochlea Ear Hear. 27: 457–465
Roy S, Shirley PS, McClelland A, et al. (1998) Circumvention of immunity to the adenovirus major coat protein hexon J.Virol. 72: 6875–6879
Salt AN, Plontke SK (1-10-2005) Local inner-ear drug delivery and pharmacokinetics Drug Discov.Today. 10: 1299–1306
Salt AN, Stopp PE (1979) The effect of cerebrospinal fluid pressure on perilymphatic flow in the opened cochlea Acta Otolaryngol. 88: 198–202
Sawada I, Kitahara M, Yazawa Y (1994) Swimming test for evaluating vestibular function in guinea pigs Acta Otolaryngol.Suppl 510: 20–23
Schuknecht HF (1982) Cochleosacculotomy for Meniere’s disease: theory, technique and results Laryngoscope 92: 853–858
Staecker H, Li D, O’malley BW Jr, et al. (2001) Gene expression in the mammalian cochlea: a study of multiple vector systems-Acta Otolaryngol. 121: 157–163
Staecker H, Van De Water TR (1998) Factors controlling hair-cell regeneration/repair in the inner ear Curr.Opin.Neurobiol. 8: 480–487
Stone IM, Lurie DI, Kelley MW, et al. (2005) Adeno-associated virus-mediated gene transfer to hair cells and support cells of the murine cochlea Mol.Ther. 11: 843–848
Sugahara K, Rubel EW, Cunningham LL (2006) JNK signaling in neomycin-induced vestibular hair cell death Hear.Res. 221: 128–135
Suzuki M, Yagi M, Brown JN, et al. (2000) Effect of transgenic GDNF expression on gentamicin-induced cochlear and vestibular toxicity Gene Ther. 7: 1046–1054
Tanyeri H, Lopez I, Honrubia V (1995) Histological evidence for hair cell regeneration after ototoxic cell destruction with local application of gentamicin in the chinchilla crista ampullaris Hear.Res. 89: 194–202
Van De Water TR, Lallemend F, Eshraghi AA, et al. (2004) Caspases, the enemy within, and their role in oxidative stress-induced apoptosis of inner ear sensory cells Otol.Neurotol. 25: 627–632
Van Wijk F, Staecker H, Keithley E, et al. (2006) Local perfusion of the tumor necrosis factor alpha blocker infiximab to the inner ear improves autoimmune neurosensory hearing loss Audiol.Neurootol. 11: 357–365
Vlachaki MT, Hernandez-Garcia A, Ittmann M, et al. (2002) Impact of preimmunization on adenoviral vector expression and toxicity in a subcutaneous mouse cancer model Mol. Ther. 6: 342–348
von Bartheld CS (5-2-2004) Axonal transport and neuronal transcytosis of trophic factors, tracers, and pathogens J.Neurobiol. 58: 295–314
Wall C III, Merfeld DM, Rauch SD, et al. (2002) Vestibular prostheses: the engineering and biomedical issues J.Vestib.Res. 12: 95–113
Wang J, Ladrech S, Pujol R, et al. (15-12-2004) Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss Cancer Res. 64: 9217–9224
Yagi M, Magal E, Sheng Z, et al. (1999) Hair cell protection from aminoglycoside ototoxicity by adenovirus-mediated overexpression of glial cell line-derived neurotrophic factor-Hum Gene Ther. 10: 813–823
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag/Wien
About this paper
Cite this paper
Praetorius, M. (2010). Gentherapie des Innenohres. In: Plinkert, P.K., Klingmann, C. (eds) Hören und Gleichgewicht. Springer, Vienna. https://doi.org/10.1007/978-3-211-99270-8_4
Download citation
DOI: https://doi.org/10.1007/978-3-211-99270-8_4
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-99269-2
Online ISBN: 978-3-211-99270-8
eBook Packages: Medicine (German Language)