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Oxygen Radical Scavengers

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New Solutions for the Heart

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Abstract

The myocardium can tolerate only relatively short periods of total myocardial ischemia without myocardial cell death. Following short ischemic periods, ischemic damage is reversible by reperfusion. However, with increasing duration and severity of ischemia, the damage inflicted to cardiomyocytes following reperfusion becomes irreversible. The combined pathologic events in the myocardium that follow a critical period of ischemia and leading to either reversible or irreversible damage to both cardiomyocytes and cardiac microvasculature is known as ischemia-reperfusion injury (Goldhaber and Weiss 1992).

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  1. Department of Cardiothoracic and Vascular Surgery, University of Mainz, Mainz, Germany

    Jack A. T. C. Parker & Uwe Mehlhorn

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  1. Jack A. T. C. Parker
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Correspondence to Uwe Mehlhorn .

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  1. , Department of Cardiac Surgery, Landesklinikum St. Pölten, Propst Führerstraße 4, St. Pölten, 3100, Austria

    Bruno K. Podesser

  2. St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, United Kingdom

    David J. Chambers

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Parker, J.A.T.C., Mehlhorn, U. (2011). Oxygen Radical Scavengers. In: Podesser, B., Chambers, D. (eds) New Solutions for the Heart. Springer, Vienna. https://doi.org/10.1007/978-3-211-85548-5_11

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