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Acute and chronic effects of oxyhemoglobin on voltage-dependent ion channels in cerebral arteries

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Cerebral Vasospasm

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 104))

Abstract

Voltage-dependent potassium (Kv) and calcium (VDCC) channels play an important role in the regulation of membrane potential and intracellular calcium concentration in cerebral artery myocytes. Recent evidence suggests VDCC activity is increased and Kv channel activity is decreased in cerebral arteries following subarachnoid hemorrhage (SAH), promoting enhanced constriction. We have examined the impact of the blood component oxyhemoglobin on Kv and VDCC function in small (100–200 µm) diameter cerebral arteries. Acute (10min) exposure of oxyhemoglobin caused cerebral artery constriction and Kv current suppression that was abolished by tyrosine kinase inhibitors and a Kv channel blocker. Although short-term oxyhemoglobin application did not directly alter VDCC activity, five-day exposure to oxyhemoglobin was associated with enhanced expression of voltage-dependent calcium channels. This work suggests that acute and chronic effects of oxyhemoglobin act synergistically to promote membrane depolarization and increased VDCC activity in cerebral arteries. These actions of oxyhemoglobin may contribute to the development of cerebral vasospasm following aneurysmal subarachnoid hemorrhage.

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Authors and Affiliations

  1. Departments of Pharmacology and Surgery, University of Vermont College of Medicine, Burlington, Vermont, USA

    M. Ishiguro, K. Murakami, K. Zvarova, A. D. Morielli & George C. Wellman

  2. Division of Neurological Surgery, University of Vermont College of Medicine, Burlington, Vermont, USA

    T. Link, B. I. Tranmer & George C. Wellman

Authors
  1. M. Ishiguro
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  2. K. Murakami
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  3. T. Link
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  4. K. Zvarova
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  5. B. I. Tranmer
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  6. A. D. Morielli
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  7. George C. Wellman
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Corresponding author

Correspondence to George C. Wellman .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Medical Faculty of Istanbul, University of Istanbul, Istanbul, Turkey

    Talat Kırış

  2. Department of Neurosurgery, Loma Linda University Medical Center, Loma Linda, USA

    John H. Zhang

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© 2008 Springer-Verlag

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Ishiguro, M. et al. (2008). Acute and chronic effects of oxyhemoglobin on voltage-dependent ion channels in cerebral arteries. In: Kırış, T., Zhang, J.H. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplement, vol 104. Springer, Vienna. https://doi.org/10.1007/978-3-211-75718-5_19

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  • DOI: https://doi.org/10.1007/978-3-211-75718-5_19

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-75717-8

  • Online ISBN: 978-3-211-75718-5

  • eBook Packages: MedicineMedicine (R0)

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