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Transcriptional regulation of stress-inducible genes in procaryotes

  • Chapter
Stress-Inducible Cellular Responses

Part of the book series: EXS ((EXS,volume 77))

Summary

In procaryotes such as Escherichia coli, transcriptional activation of heat shock genes in response to elevated temperature is caused primarily by transient increase in the amount of σ32 (rpoH gene product) specifically required for transcription from the heat shock promoters. The increase in σ32 level results from increased translation of rpoH mRNA and from stabilization of σ32 which is ordinarily very unstable. Some of the factors and cis-acting elements that constitute the complex regulatory circuits have been identified and characterized, but detailed mechanisms as well as nature of sensors and signals remain to be elucidated. Whereas this “classical”heat shock regulon (σ32 regulon) provides major protective functions against thermal stress, a second heat shock regulon mediated by σ32 (σ24) encodes functions apparently required under more extreme conditions, and is activated by responding to extracyto- plasmic signals. These regulons mediated by minor σ factors (σ32 in particular) appear to be conserved in most gram-negative bacteria, but not in gram-positive bacteria.

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Authors and Affiliations

  1. HSP Research Institute, Kyoto Research Park, Shimogyo-ku, 600, Kyoto, Japan

    T. Yura, K. Nakahigashi & M. Kanemori

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  1. T. Yura
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  2. K. Nakahigashi
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  3. M. Kanemori
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Editors and Affiliations

  1. Department of Pharmacology, AMGEN Center, 1840 De Havilland Drive, 15-2-A-224, 91320-1789, Thousand Oaks, CA, USA

    U. Feige

  2. Department of Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Honkomagome 3-18-22, Bunkyo-Ku, Tokyo 113, Japan

    I. Yahara

  3. Department of Biochemistry, Molecular and Cell Biology Northwestern University, 2153 Sheridan Road, 60208-3500, Evanston, IL, USA

    R. I. Morimoto

  4. Laboratoire de Physiologie Respiratoire, Université Paris 5 UFR Cochin Port-Royal, 24, rue du Faubourg Saint-Jacques, F-75014, Paris, France

    B. S. Polla

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Yura, T., Nakahigashi, K., Kanemori, M. (1996). Transcriptional regulation of stress-inducible genes in procaryotes. In: Feige, U., Yahara, I., Morimoto, R.I., Polla, B.S. (eds) Stress-Inducible Cellular Responses. EXS, vol 77. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9088-5_11

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  • DOI: https://doi.org/10.1007/978-3-0348-9088-5_11

  • Publisher Name: Birkhäuser Basel

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