Abstract
Errors in chromosome distribution in meiosis and mitosis result in cells with missing or extra chromosomes, which can cause birth defects in children and cancer in adults. Chromosome distribution is determined by chromosome attachment to the mitotic spindle (reviewed in [1]). Proper attachment of daughter chromosomes to opposite spindle poles leads to movement to opposite poles in anaphase, with the fortunate consequence that each daughter cell contains one copy of each chromosome. Attachment begins with chance events, in which growing microtubules accidentally encounter a kinetochore, the microtubule attachment site on each chromosome (Fig. 1).
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Nicklas, R.B. (2000). Chromosomes in mitosis: chance and checkpoint. In: Olmo, E., Redi, C.A. (eds) Chromosomes Today. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8484-6_6
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DOI: https://doi.org/10.1007/978-3-0348-8484-6_6
Publisher Name: Birkhäuser, Basel
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