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Nitric Oxide in Exhaled Air: Relevance in Inflammatory Lung Disease

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Nitric Oxide in Pulmonary Processes

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

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Abstract

Nitric oxide (NO) is produced by many cells within the respiratory tract and endogenous NO may play an important signalling role in the physiological control of airway function and in the pathophysiology of airway diseases [1–3]. All three isoforms of NO synthase (NOS) exist within the respiratory tract [4–6]. The endothelial constitutive isoform (eNOS) is localised to bronchial endothelial cells and to epithelial cells [7] and the neuronal isoform (nNOS) to parasympathetic nerves and to epithelial cells [8, 9]. Inducible NOS (iNOS) may be localised to several cell types, including epithelial cells and macrophages [10–12] and may be expressed even in the normal human respiratory tract (Fig. 1).

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Authors and Affiliations

  1. Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London, SW3 6LY, UK

    Peter J. Barnes & Sergei A. Kharitonov

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  1. Peter J. Barnes
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  2. Sergei A. Kharitonov
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  1. Pharmacology Department, Rhône-Poulenc Rorer Research & Development, Rainham Road South, Dagenham, Essex, RM 10 7XS, UK

    Maria G. Belvisi

  2. Unit of Critical Care Medicine Imperial College Medical School, Royal Brompton Hospital, Sidney Street, London, SW3 6NP, UK

    Jane A. Mitchell

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Barnes, P.J., Kharitonov, S.A. (2000). Nitric Oxide in Exhaled Air: Relevance in Inflammatory Lung Disease. In: Belvisi, M.G., Mitchell, J.A. (eds) Nitric Oxide in Pulmonary Processes. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8474-7_9

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