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Nitric Oxide and Bronchial Hyperresponsiveness

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Nitric Oxide in Pulmonary Processes

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

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Abstract

Increasing evidence points to an important role for nitric oxide (NO) in the regulation of pulmonary functions and in pulmonary disease [1–4]. NO is present in exhaled air of animals and humans [1, 5]. The respiratory tract, nerves endothelial cells, vascular and airway smooth muscle cells, inflammatory cells (macrophages, neutrophils, mast cells) and the airway epithelium are sources for NO production [2]. The different effects of NO are mediated by the activation of soluble guanylyl cyclase, with as a consequence, an increase of cyclic guanosine monophosphate (cGMP) in the target cell.

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Authors and Affiliations

  1. Department of Pharmacology and Pathophysiology, Faculty of Pharmacy, Utrecht University, The Netherlands

    Frans P. Nijkamp & Gert Folkerts

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  1. Frans P. Nijkamp
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  2. Gert Folkerts
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Editors and Affiliations

  1. Pharmacology Department, Rhône-Poulenc Rorer Research & Development, Rainham Road South, Dagenham, Essex, RM 10 7XS, UK

    Maria G. Belvisi

  2. Unit of Critical Care Medicine Imperial College Medical School, Royal Brompton Hospital, Sidney Street, London, SW3 6NP, UK

    Jane A. Mitchell

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Nijkamp, F.P., Folkerts, G. (2000). Nitric Oxide and Bronchial Hyperresponsiveness. In: Belvisi, M.G., Mitchell, J.A. (eds) Nitric Oxide in Pulmonary Processes. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8474-7_6

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  • DOI: https://doi.org/10.1007/978-3-0348-8474-7_6

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9582-8

  • Online ISBN: 978-3-0348-8474-7

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