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Role of Nitric Oxide in the Regulation of Pulmonary Vascular Tone

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Nitric Oxide in Pulmonary Processes

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

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Abstract

The pulmonary circulation is a low pressure, low resistance, high flow system regulated through both active and passive factors [1–4]. Active factors alter pulmonary vascular resistance and tone by causing contraction or relaxation of vascular smooth muscle and include neural and humoral mechanisms, and gaseous regulators. Passive factors alter pulmonary vascular resistance and/or blood flow independently of changes in vascular tone and include variation in cardiac output, left atrial, airway and interstitial pressures, gravitational force, and vascular obstruction or recruitment. Although passive factors may be important, the pulmonary circulation is regulated overwhelmingly by active control mechanisms [1–4].

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Authors and Affiliations

  1. Long Island Jewish Medical Center, Albert Einstein College of Medicine, 270-5 76th Avenue, New Hyde Park, NY, 11040, USA

    Shu F. Liu

  2. National Heart and Lung Institute, Unit of Critical Care, Royal Brompton Hospital, Sidney Street, London, SW3 6NP, UK

    Timothy W. Evans

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  1. Shu F. Liu
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Editors and Affiliations

  1. Pharmacology Department, Rhône-Poulenc Rorer Research & Development, Rainham Road South, Dagenham, Essex, RM 10 7XS, UK

    Maria G. Belvisi

  2. Unit of Critical Care Medicine Imperial College Medical School, Royal Brompton Hospital, Sidney Street, London, SW3 6NP, UK

    Jane A. Mitchell

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Liu, S.F., Evans, T.W. (2000). Role of Nitric Oxide in the Regulation of Pulmonary Vascular Tone. In: Belvisi, M.G., Mitchell, J.A. (eds) Nitric Oxide in Pulmonary Processes. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8474-7_5

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  • DOI: https://doi.org/10.1007/978-3-0348-8474-7_5

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9582-8

  • Online ISBN: 978-3-0348-8474-7

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