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Inhibiting cytokine-processing enzymes

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Novel Cytokine Inhibitors

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Cytokines and local growth factors are important soluble mediators that play a fundamental role in regulating the growth and differentiated function of many cell types. They mediate their effects by binding to membrane-bound receptors which initiates a complex sequence of signaling events that leads to a cellular response. The magnitude of this effect reflects the complex balance that exists between the different components of the cytokine system. These include the cytokine itself, the membrane-bound receptor, and the presence or absence of soluble receptor and/or receptor antagonists.

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Authors and Affiliations

  1. Division of Biochemical and Musculoskeletal Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK

    Peter I. Croucher, Ingunn Holen & Philip G. Hargreaves

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  1. Peter I. Croucher
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  2. Ingunn Holen
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  1. Celltech Chiroscience, 216 Bath Road, Slough Berkshire, SL1 4EN, UK

    Gerry A. Higgs

  2. Cellular Microbiology Research Group Eastman Dental Institute, University College London, 256 Gray’s Inn Road, London, WC1X 8LD, UK

    Brian Henderson

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Croucher, P.I., Holen, I., Hargreaves, P.G. (2000). Inhibiting cytokine-processing enzymes. In: Higgs, G.A., Henderson, B. (eds) Novel Cytokine Inhibitors. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8450-1_5

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  • DOI: https://doi.org/10.1007/978-3-0348-8450-1_5

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