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Cell signaling and cytokine induction by lipopolysaccharide

  • Chapter
Novel Cytokine Inhibitors

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Multicellular organisms have evolved molecular systems to recognize the structural hallmarks of pathogens and an arsenal of responses to contain and ultimately eliminate invaders. Lipopolysaccharide (LPS) derived from the cell walls of Gram-negative bacteria is an important initiator of such “innate” immune responses. This recognition normally leads to a robust local immune response to invading bacteria which is protective; however, if LPS is present in the blood, the response becomes systemic and can lead to endotoxic shock and death. The ancient threat of sepsis remains an important clinical problem today and motivates much of the interest in the molecular biology of LPS responses. Here we review recent literature relevant to LPS-induced signaling in myeloid cells, with emphasis on the contribution of these signals to cytokine expression.

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  1. Chiron Corp, 4560 Horton St, Emeryville, CA, 94608, USA

    Mary Lee MacKichan

  2. G.W. Hooper Foundation, University of California, San Francisco, CA, 94143-0552, USA

    Anthony L. DeFranco

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    Brian Henderson

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MacKichan, M.L., DeFranco, A.L. (2000). Cell signaling and cytokine induction by lipopolysaccharide. In: Higgs, G.A., Henderson, B. (eds) Novel Cytokine Inhibitors. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8450-1_2

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