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Salutary effect of autoimmune T cells after central nervous system injury

  • Chapter
Inflammation and Stroke

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

The interaction between the central nervous system (CNS) and the immune system is unique, partly because it is characterized by “immune privilege”, involving restriction of local immune responses within the CNS. This phenomenon is probably an evolutionary adaptation developed to protect the intricate neuronal networks of the CNS from potentially disruptive incursion by the immune system [1–3]. An early definition of immune privilege was based on the assumption that the immune system ignores the CNS. This concept of immune ignorance was supported by the poor ability of the CNS to reject allografts, i.e. tissue grafts from the same species but from a different major histocompatibility complex (MHC) haplotype. Immune privilege was thought to be maintained by the harboring of antigens within the CNS and the inability of immune cells to enter the CNS under normal physiological conditions. Any entry of leukocytes was viewed as evidence of pathology [4–8]. Several observations have indicated that the CNS is accessible to immune cells, and that immune privilege is the result of an active barrier, or of several mechanisms collectively endowing the CNS with unique immune characteristics [9–13]. It thus appears that protection of the CNS from pathogen invasion has been achieved at the cost of forfeiting some of the advantages normally bestowed on damaged tissues by the immune system.

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Author information

Authors and Affiliations

  1. Department of Neurobiology, The Weizmann Institute of Science, Rehovot, 76100, Israel

    Michal Schwartz

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  1. Michal Schwartz
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Editors and Affiliations

  1. Cardiovascular Diseases Research Experimental Station, DuPont Pharmaceuticals Company, Route 141 & Henry Clay Road, Wilmington, DE, 19880, USA

    Giora Z. Feuerstein

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© 2001 Springer Basel AG

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Schwartz, M. (2001). Salutary effect of autoimmune T cells after central nervous system injury. In: Feuerstein, G.Z. (eds) Inflammation and Stroke. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8297-2_4

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  • DOI: https://doi.org/10.1007/978-3-0348-8297-2_4

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9508-8

  • Online ISBN: 978-3-0348-8297-2

  • eBook Packages: Springer Book Archive

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