Summary
To speed up the structure-based analysis of protein function, we have developed the concept of Experimentally Validated 3D Models (EVAMs), i.e., structural models that can be generated relatively fast by a combination of bioinformatics and experiments. Here, we test the suitability of EVAMs for functional studies by applying the concept to two small proteins, saposin B and saposin C. We find that EVAMs are well able to explain some of the functional properties of these proteins, such as their pH-dependent association with lipid bilayers, that are known from independent biophysical experiments.
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Hoffmann, D. (2003). A Functional Study on Saposin B and C Using Experimentally Validated Models. In: Alt, W., Chaplain, M., Griebel, M., Lenz, J. (eds) Polymer and Cell Dynamics. Mathematics and Biosciences in Interaction. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8043-5_3
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DOI: https://doi.org/10.1007/978-3-0348-8043-5_3
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-9417-3
Online ISBN: 978-3-0348-8043-5
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