Skip to main content

Desialylated low density lipoproteins and atherosclerosis

  • Chapter
Free Radicals and Aging

Part of the book series: EXS ((EXS,volume 62))

Summary

Oxidative modification of LDL is accompanied by a number of compositional and structural changes, now well known. In addition, other atherogenic modifications of LDL exist, such as desialylation. The present article summarizes the recent data related to desialylated LDL and to the presence of these LDL in blood plasma of patients with coronary atherosclerosis. In addition, this review examines the sensitivity of these LDL to peroxidative stress.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Camejo, G., Lopez, A., Lopez, F., and Quinones, J. (1985) Interaction of Low Density Lipoproteins with arterial proteoglycans. The role of charge and sialic acid content. Atherosclerosis 55: 93–105.

    CAS  Google Scholar 

  • Chapman, M. J., Laplaud, P. M., Luc, G., Forgez, P., Bruckert, E., Goulinet, S., and Lagrange, D. (1988) Further resolution of the LDL spectrum in normal human plasma: physicochemical characteristics of discrete subspecies separated by density gradient ultra- centrifugation. J. Lipid Res. 29: 442–458.

    PubMed  CAS  Google Scholar 

  • De Graaf, J., Hak-Lemmers, H. L. M., Hectors, M. P. C., Demacker, P. N. M., Hendriks, J. C. M., and Stalenhoef, A. F. H. (1991) Enhanced susceptibihty to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects. Arteriosclerosis and Thrombosis 11: 298–306.

    Article  PubMed  Google Scholar 

  • Dousset, N., and Douste-Blazy, L. (1969) Etude chromatographique des lécithines plasma- tiques irradiées (1969) Bull. Soc. Chim. Biol. 51: 1013–1020.

    CAS  Google Scholar 

  • Dousset, N., Dousset, J. C., and Douste-Blazy, L. (1981) Influence of dicarboxylic phosphatidylcholines on the stability and phase transition of phosphatidylcholine liposomes. Biochim. Biophys. Acta 641: 1–10.

    Article  PubMed  CAS  Google Scholar 

  • Dousset, N., Dousset, J. C., Solérà, M. L., Salvayre, R., and Valdiguié, P (1991) Biochemical modifications of desialylated and peroxidized LDL. 57th EAS Meeting, Lisbon, p. 12.

    Google Scholar 

  • Esterbauer, H., Jürgens, G., Qhehendergen, O., and Koller, E. (1987) Autoxidation of human LDL: loss of polyunsaturated acids and vitamin E and generation of aldehydes. J. Lipid Res. 28: 495–509.

    PubMed  CAS  Google Scholar 

  • Esterbauer, H., Dieber-Rotheneder, M., Waeg, G., Striegl, G., and Jürgens, G. (1990) Biochemical, structural, and functional properties of oxidized low density lipoprotein. Chem. Res. Toxicol. 3: 77–92.

    Article  PubMed  CAS  Google Scholar 

  • Filipovic, I., and Buddecke, E. (1979) Role of net charge of low density lipoproteins in high affinity binding and uptake by cultured cells. Biochem. Biophys. Res. Com 38: 485–490.

    Article  Google Scholar 

  • Filipovic, I., Schwarzmann, G., Mraz, W., Wiegandt, H., and Buddecke, E. (1979) Sialic acid content of low density lipoproteins controls their binding and uptake by cultured cells. Eur. J. Biochem. 93: 51–55.

    Article  PubMed  CAS  Google Scholar 

  • Görög, P., and Pearson, J. D. (1985) Sialic acid moieties on surface glycoproteins protect endothehal cells from proteolytic damage. J. Pathol. 146: 205–212.

    Article  PubMed  Google Scholar 

  • Hurt, E., Bondjers, G., and Camejo, G. (1990) Interaction of LDL with human arterial proteoglycans stimulates its uptake by human monocyte-derived macrophages. J. Lipid Res 31: 443–454.

    PubMed  CAS  Google Scholar 

  • Jialal, I., Freeman, D. A., and Grundy, S. M. (1991) Varying susceptibility of different low density lipoproteins to oxidative modification. Arteriosclerosis and Thrombosis 11: 482–488.

    Article  PubMed  CAS  Google Scholar 

  • Jürgens, G., Hoff, H. F., Chilsom, G. M., and Esterbauer, H. (1987) Modification of human serum low density lipoprotein by oxidation. Characterization and pathophysiological implications. Chem. Phys. Lipids 45: 315–336.

    Google Scholar 

  • Khoo, J. C., Miller, E., McLoughlin, P., and Steinberg, D. (1988) Enhanced macrophage uptake of low density lipoprotein after self-aggregation. Arteriosclerosis 8: 348–358.

    Article  PubMed  CAS  Google Scholar 

  • Khoo, J. C., Miller, E., McLoughHn, P., and Steinberg, D. (1990) Prevention of low density lipoprotein aggregation by high density lipoprotein or apolipoprotein A-1. J. Lipid Res. 31: 645–652.

    PubMed  CAS  Google Scholar 

  • La Belle, M., and Krauss, R. M. (1990) Differences in carbohydrate content of low density lipoproteins associated with low density lipoprotein subclass patterns. J. Lipid Res. 31: 1577–1588.

    PubMed  Google Scholar 

  • Malmendier, C., Feremans, W. W., and Fontaine M. (1979) The effect of sialic acid removal on very low density lipoprotein. Artery 6: 144–156.

    CAS  Google Scholar 

  • Malmendier, C., Delcroix, C., and Fontaine, M. (1980) Effect of sialic acid removal on human low density hpoprotein catabolism in vivo. Atherosclerosis 37: 277–284.

    Article  PubMed  CAS  Google Scholar 

  • Mullarkey, C. J., Edelstein, D., and Brownlee, M. (1990) Free radical generation by early glycation products: a mechanism of accelerated atherogenesis in diabetes. Biochem. Biophys. Res. Commun. 173: 932–939.

    Article  PubMed  CAS  Google Scholar 

  • Naruszewicz, M., Sehnger, E., Dufour, R., and Davignon, J. (1991) Modification of Lp(a) and the effect of antioxidants. 57th EAS Meeting, Lisbon, p. 5.

    Google Scholar 

  • Orekhov, A. N., Tertov, V. V., Mukhin, D. N., and Mikhailenko, L A. (1989) Modification of low density lipoprotein by desialylation causes hpid accumulation in cultured cells: Discovery of desialylated hpoprotein with altered cellular metabolism in the blood of atherosclerotic patients. Biochem. Biophys. Res. Commun. 162: 206–211.

    Article  PubMed  CAS  Google Scholar 

  • Orekhov, A. N. (1991) Cellular mechanisms of atherosclerosis. 57th EAS Meeting, Lisbon, pp. 64–65.

    Google Scholar 

  • Orekhov, A. N., Tertov, V. V., Kabakav, A. E., Adamova, L Y., Pokrovsky, S. N., and Smirnov, V. N. (1991) Autoantibodies against modified low density lipoprotein. Non lipid factor of blood plasma that stimulates foam cell formation. Arteriosclerosis and Thrombosis 11: 316–326.

    CAS  Google Scholar 

  • Sambandam, T., Baker, J. R., Christner, J. E., and Ekborg, S. L. (1991) Specificity of the low density hpoprotein-glycosaminogiycan interaction. Arteriosclerosis and Thrombosis 11: 561–568.

    Article  PubMed  CAS  Google Scholar 

  • Sattler, W., Kostner, G. M., Waeg, G., and Esterbauer, H. (1991) Oxidation of lipoprotein Lp(a). A comparison with low density lipoproteins. Biochim. Biophys. Acta 1081: 65–74.

    CAS  Google Scholar 

  • Steele, R. H., and Wagner, W. D. (1987) Lipoprotein interaction with artery wall derived proteoglycan: Comparisons between atherosclerosis-susceptible WC-2 and resistant Show Racer pigeons. Atherosclerosis 65: 63–73.

    Article  PubMed  CAS  Google Scholar 

  • Steinbrecher, U. P., Parthasarathy, S., Leake, D. S., Witztum, J. L., and Steinberg, D. (1984) Modification of low density lipoprotein by endothehal cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc. Natl. Acad. Sci. USA 81: 3883–3887.

    Article  PubMed  CAS  Google Scholar 

  • Steinbrecher, U. P., Zhang, H., and Lougheed, M. (1990) Role of oxidatively modified LDL in atherosclerosis. Free Radical Biol. Med. 9: 155–168.

    Article  CAS  Google Scholar 

  • Swaminathan, N., and Aladjem, F. (1976) The monosaccharide composition and sequence of the carbohydrate moiety of human serum low density Hpoproteins. Biochemistry 15: 1516–1522.

    Article  PubMed  CAS  Google Scholar 

  • Tertov, V. V., Sobenin, L A., Gabbasov, Z. A., Popov, E. G., And Orekhov, A. N. (1989) Lipoprotein aggregation as an essential condition of intracellular hpid accumulation caused by modified low density lipoproteins. Biochem. Biophys. Res. Conrniun. 163: 489–494.

    Article  CAS  Google Scholar 

  • Wolff, S. P., Jiang, Z. Y., and Hunt, J. V. (1991) Protein Glycation and oxidative stress in diabetes meUitus and ageing. Free Radical Biol. Med. 10: 339–352.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Birkhäuser Verlag Basel/Switzerland

About this chapter

Cite this chapter

Dousset, N., Dousset, J.C., Soléra, M.L., Valdiguié, P. (1992). Desialylated low density lipoproteins and atherosclerosis. In: Emerit, I., Chance, B. (eds) Free Radicals and Aging. EXS, vol 62. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7460-1_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-7460-1_16

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7462-5

  • Online ISBN: 978-3-0348-7460-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics