Summary
Oxidative modification of LDL is accompanied by a number of compositional and structural changes, now well known. In addition, other atherogenic modifications of LDL exist, such as desialylation. The present article summarizes the recent data related to desialylated LDL and to the presence of these LDL in blood plasma of patients with coronary atherosclerosis. In addition, this review examines the sensitivity of these LDL to peroxidative stress.
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References
Camejo, G., Lopez, A., Lopez, F., and Quinones, J. (1985) Interaction of Low Density Lipoproteins with arterial proteoglycans. The role of charge and sialic acid content. Atherosclerosis 55: 93–105.
Chapman, M. J., Laplaud, P. M., Luc, G., Forgez, P., Bruckert, E., Goulinet, S., and Lagrange, D. (1988) Further resolution of the LDL spectrum in normal human plasma: physicochemical characteristics of discrete subspecies separated by density gradient ultra- centrifugation. J. Lipid Res. 29: 442–458.
De Graaf, J., Hak-Lemmers, H. L. M., Hectors, M. P. C., Demacker, P. N. M., Hendriks, J. C. M., and Stalenhoef, A. F. H. (1991) Enhanced susceptibihty to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects. Arteriosclerosis and Thrombosis 11: 298–306.
Dousset, N., and Douste-Blazy, L. (1969) Etude chromatographique des lécithines plasma- tiques irradiées (1969) Bull. Soc. Chim. Biol. 51: 1013–1020.
Dousset, N., Dousset, J. C., and Douste-Blazy, L. (1981) Influence of dicarboxylic phosphatidylcholines on the stability and phase transition of phosphatidylcholine liposomes. Biochim. Biophys. Acta 641: 1–10.
Dousset, N., Dousset, J. C., Solérà, M. L., Salvayre, R., and Valdiguié, P (1991) Biochemical modifications of desialylated and peroxidized LDL. 57th EAS Meeting, Lisbon, p. 12.
Esterbauer, H., Jürgens, G., Qhehendergen, O., and Koller, E. (1987) Autoxidation of human LDL: loss of polyunsaturated acids and vitamin E and generation of aldehydes. J. Lipid Res. 28: 495–509.
Esterbauer, H., Dieber-Rotheneder, M., Waeg, G., Striegl, G., and Jürgens, G. (1990) Biochemical, structural, and functional properties of oxidized low density lipoprotein. Chem. Res. Toxicol. 3: 77–92.
Filipovic, I., and Buddecke, E. (1979) Role of net charge of low density lipoproteins in high affinity binding and uptake by cultured cells. Biochem. Biophys. Res. Com 38: 485–490.
Filipovic, I., Schwarzmann, G., Mraz, W., Wiegandt, H., and Buddecke, E. (1979) Sialic acid content of low density lipoproteins controls their binding and uptake by cultured cells. Eur. J. Biochem. 93: 51–55.
Görög, P., and Pearson, J. D. (1985) Sialic acid moieties on surface glycoproteins protect endothehal cells from proteolytic damage. J. Pathol. 146: 205–212.
Hurt, E., Bondjers, G., and Camejo, G. (1990) Interaction of LDL with human arterial proteoglycans stimulates its uptake by human monocyte-derived macrophages. J. Lipid Res 31: 443–454.
Jialal, I., Freeman, D. A., and Grundy, S. M. (1991) Varying susceptibility of different low density lipoproteins to oxidative modification. Arteriosclerosis and Thrombosis 11: 482–488.
Jürgens, G., Hoff, H. F., Chilsom, G. M., and Esterbauer, H. (1987) Modification of human serum low density lipoprotein by oxidation. Characterization and pathophysiological implications. Chem. Phys. Lipids 45: 315–336.
Khoo, J. C., Miller, E., McLoughlin, P., and Steinberg, D. (1988) Enhanced macrophage uptake of low density lipoprotein after self-aggregation. Arteriosclerosis 8: 348–358.
Khoo, J. C., Miller, E., McLoughHn, P., and Steinberg, D. (1990) Prevention of low density lipoprotein aggregation by high density lipoprotein or apolipoprotein A-1. J. Lipid Res. 31: 645–652.
La Belle, M., and Krauss, R. M. (1990) Differences in carbohydrate content of low density lipoproteins associated with low density lipoprotein subclass patterns. J. Lipid Res. 31: 1577–1588.
Malmendier, C., Feremans, W. W., and Fontaine M. (1979) The effect of sialic acid removal on very low density lipoprotein. Artery 6: 144–156.
Malmendier, C., Delcroix, C., and Fontaine, M. (1980) Effect of sialic acid removal on human low density hpoprotein catabolism in vivo. Atherosclerosis 37: 277–284.
Mullarkey, C. J., Edelstein, D., and Brownlee, M. (1990) Free radical generation by early glycation products: a mechanism of accelerated atherogenesis in diabetes. Biochem. Biophys. Res. Commun. 173: 932–939.
Naruszewicz, M., Sehnger, E., Dufour, R., and Davignon, J. (1991) Modification of Lp(a) and the effect of antioxidants. 57th EAS Meeting, Lisbon, p. 5.
Orekhov, A. N., Tertov, V. V., Mukhin, D. N., and Mikhailenko, L A. (1989) Modification of low density lipoprotein by desialylation causes hpid accumulation in cultured cells: Discovery of desialylated hpoprotein with altered cellular metabolism in the blood of atherosclerotic patients. Biochem. Biophys. Res. Commun. 162: 206–211.
Orekhov, A. N. (1991) Cellular mechanisms of atherosclerosis. 57th EAS Meeting, Lisbon, pp. 64–65.
Orekhov, A. N., Tertov, V. V., Kabakav, A. E., Adamova, L Y., Pokrovsky, S. N., and Smirnov, V. N. (1991) Autoantibodies against modified low density lipoprotein. Non lipid factor of blood plasma that stimulates foam cell formation. Arteriosclerosis and Thrombosis 11: 316–326.
Sambandam, T., Baker, J. R., Christner, J. E., and Ekborg, S. L. (1991) Specificity of the low density hpoprotein-glycosaminogiycan interaction. Arteriosclerosis and Thrombosis 11: 561–568.
Sattler, W., Kostner, G. M., Waeg, G., and Esterbauer, H. (1991) Oxidation of lipoprotein Lp(a). A comparison with low density lipoproteins. Biochim. Biophys. Acta 1081: 65–74.
Steele, R. H., and Wagner, W. D. (1987) Lipoprotein interaction with artery wall derived proteoglycan: Comparisons between atherosclerosis-susceptible WC-2 and resistant Show Racer pigeons. Atherosclerosis 65: 63–73.
Steinbrecher, U. P., Parthasarathy, S., Leake, D. S., Witztum, J. L., and Steinberg, D. (1984) Modification of low density lipoprotein by endothehal cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc. Natl. Acad. Sci. USA 81: 3883–3887.
Steinbrecher, U. P., Zhang, H., and Lougheed, M. (1990) Role of oxidatively modified LDL in atherosclerosis. Free Radical Biol. Med. 9: 155–168.
Swaminathan, N., and Aladjem, F. (1976) The monosaccharide composition and sequence of the carbohydrate moiety of human serum low density Hpoproteins. Biochemistry 15: 1516–1522.
Tertov, V. V., Sobenin, L A., Gabbasov, Z. A., Popov, E. G., And Orekhov, A. N. (1989) Lipoprotein aggregation as an essential condition of intracellular hpid accumulation caused by modified low density lipoproteins. Biochem. Biophys. Res. Conrniun. 163: 489–494.
Wolff, S. P., Jiang, Z. Y., and Hunt, J. V. (1991) Protein Glycation and oxidative stress in diabetes meUitus and ageing. Free Radical Biol. Med. 10: 339–352.
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© 1992 Birkhäuser Verlag Basel/Switzerland
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Dousset, N., Dousset, J.C., Soléra, M.L., Valdiguié, P. (1992). Desialylated low density lipoproteins and atherosclerosis. In: Emerit, I., Chance, B. (eds) Free Radicals and Aging. EXS, vol 62. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7460-1_16
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DOI: https://doi.org/10.1007/978-3-0348-7460-1_16
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