Abstract
The hippocampus is an important link in current models of neural control of entrance into and arousal from hibernation (1,4,8). Heller (4) suggests that the hippocampus is part of a feedback loop inhibiting the activity of the brain stem reticular formation during entrance into hibernation and during deep hibernation. Beckman and Stanton (1) assume a reciprocal inhibitory interaction between the hippocampus and the midbrain reticular formation as well as between the hippocampus and the hypothalamus. On the other hand, Pakhotin et al. (8) regard a tonic inhibitory influence of the hippocampus on the reticular formation during hibernation as unlikely. Instead, they suppose a modulatory action of the septohippocampal arousing system on hypothalamic thermoregulatory mechanisms during -activity. Excitability changes in neurons in the medial septum and the hippocampus are possibly involved in triggering the exit from a bout of hibernation (8). The transmission properties of hippocampal neurons are modified in connection with hibernation. The temperature below which synaptic transmission is blocked (the threshold temperature) is lowered (6,9) and paired-pulse depression at low temperatures is reduced (6).
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References
Beckman, AL, Stanton, TL (1982): Properties of the CNS during the state of hibernation. In: The neural basis of behaviour. Beckman, AL ed. New York: MPTP Press, 19–45.
Cai, Y-P, Zhao, H-Q, Huang, Q-H (1989): Reevaluation of involvement of norepinephrine and serotonin in initiation of hibernation. In: Living in the Cold II. Malan, A, Canguilhem, B eds. Montrouge, London: John Libbey, 477–484.
Canguilhem, B, Miro, J-L, Kempf, E, Schmitt, P (1986): Does serotonin play a role in entrance into hibernation? Am J Physiol 251, R755–761.
Heller, HC (1979): Hibernation: Neural aspects. Ann Rev Physiol 41, 305–321.
Horrigan, DJ, Horowitz, JM (1990): Thermal dependence of serotonergic modulation of neural activity in the hamster. J Comp Physiol A 167, 79–88.
Igelmund, P, Heinemann, U, Klußmann, FW (1993): Hibernation-related modification of activity-dependent properties of synaptic transmission in hamster hippocampus. Neurosci Res Comm 13:167–173.
Lee, TF, Nürnberger, F, Wang, LCH (1993): Possible involvement of endogenous adenosine in hibernation. In: Live in the Cold: Ecological, Physiological, and Molecular Mechanisms. Carey, C, Florant, GL, Wunder, BA, Horwitz, B, eds. Boulder, Oxford: Westview Press, 315–322.
Pakhotin, P, Pakhotina, ID, Belousov, AB (1993): The study of brain slices from hibernating mammals in vitro and some approaches to the analysis of hibernation problems in vivo. Progr Neurobiol 40, 123–161.
Thomas, MP, Martin, SM, Horowitz, JM (1986): Temperature effects on evoked potentials of hippocampal slices from noncold-acclimated, cold-acclimated and hibernating hamsters. J Therm Biol 11, 213–218.
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© 1994 Birkhäuser Verlag Basel
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Igelmund, P., Spangenberger, H., Nikmanesh, F.G. (1994). Hibernation-Related Changes in the Effects of Neuromodulators: An In Vitro Study on Synaptic Transmission in Hippocampal Slices. In: Zeisberger, E., Schönbaum, E., Lomax, P. (eds) Thermal Balance in Health and Disease. APS Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7429-8_8
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DOI: https://doi.org/10.1007/978-3-0348-7429-8_8
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