Abstract
Despite the fact that it is only 30 years since thermogenesis was suggested to be the function of brown adipose tissue, the role of brown adipose tissue as a unique thermogenic organ in mammals is now well established. Kurt Brück (1) early realised its significance for thermoregulation of the newborn of all mammalian species, including the human infant, and it is therefore very appropriate to present an overview of present knowledge on brown adipose tissue in this symposium, dedicated to his memory. The role of the sympathetic nervous system as the means of activation of the acute heat production in brown adipose tissue has long been realised, but as the result of continuous study of the tissue, it has been understood that the sympathetic nervous system, through norepinephrine release, also plays a dominating role for the development of the tissue in response to e.g. prolonged cold exposure — i.e. for the so-called recruitment process. Certain circulating hormones, and some growth factors, may also influence tissue metabolism and development, but the role of these agents may mainly be seen as permissive, i.e. their presence may be necessary for the recruitment process but they do not in themselves constitute a sufficient signal for tissue recruitment; rather, the chronic adrenergic stimulation seems to have this role. It is therefore clear that an understanding of the responses of the tissue to adrenergic stimulation is the predominant prerequisite for an understanding both of the acute functioning of the tissue and of its recruitment in response to physiological stimuli. We will therefore in the following concentrate on the adrenergic receptors in the tissue and on their effects, both on the acute thermogenic response and on cell proliferation and differentiation during the recruitment process.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Brück, K, Wünnenberg, B (1965): Untersuchungen über die Bedeutung des multiloculären Fettgewebes für de Thermogenese des neugeborenen Meerschweinchens. Pflügers Arch 283, 1–16.
Himms-Hagen, J (1990): Brown adipose tissue thermogenesis: role in thermoregulation, energy regulation and obesity. In: Thermoregulation: Physiology and Biochemistry. Schönbaum, E, Lomax, P eds. New York: Pergamon Press, Inc., 327–414.
Kobilka, B (1992): Adrenergic receptors as models for G protein-coupled receptors. Annu RevNeurosci 15,87–114.
Raasmaja, A (1990): a x - and ß-adrenergic receptors in brown adipose tissue and the adrenergic regulation of thyroxine 5’-deiodinase. Acta Physiol Scand (Suppl 590) 139, 1–64.
Strosberg, AD (1992): Biotechnology of ß-adrenergic receptors. Mol Neurobiol 4, 211–250.
Mohell, N, Connolly, E, Nedergaard, J (1987): Distinction between mechanisms underlying a- and ß-adrenergic respiratory stimulation in brown fat cells. Am J Physiol 253, C301-C308.
Arch, J (1989): The brown adipocyte ß-adrenoceptor. Proc Nutr Soc 48, 215–223.
Mohell, N, Dicker, A (1989): The ß-adrenergic radioligand (3H)CGP-12177, generally classified as an antagonist, is a thermogenic agonist in brown adipose tissue. Biochem J 261, 401–405.
Zhao, J, Unelius, L, Cannon, B, Nedergaard, J (1993): Coexisting ß-adrenoceptor subtypes: significance for the thermogenic process in brown-fat cells. Subm for publ.
Granneman, JG (1990): Norepinephrine and BRL 37344 stimulate adenylate cyclase by different receptors in rat brown adipose tissue. J Pharmacol Exp Ther 254, 508–513.
Holm, C, Fredrikson, G, Cannon, B, Beifrage, P (1987): Hormone-sensitive lipase in brown adipose tissue: Identification and effect of cold exposure. Biosci Rep 7, 897–904.
Nedergaard, J, Cannon, B (1992): The uncoupling protein thermogenin and mitochondrial thermogenesis. In: New Comprehensive Biochemistry vol. 23: Molecular Mechanisms in Bioenergetics. Ernster, L eds. Amsterdam: Elsevier, 385–420.
Masuno, H, Schultz, CJ, Park, JW, Blanchette-Mackie, EJ, Mateo, C, Scow, RO (1991): Glycosylation, activity and secretion of lipoprotein lipase in cultured brown adipocytes of newborn mice. Effect of tunicamycin, monensin, 1-deoxymannojirimycin and swainsonine. Biochem J 277, 801–809.
Sasaki, A, Goldberg, IJ (1992): Lipoprotein lipase release from BFC-1β adipocytes. Effects of triglyceride-rich lipoproteins and lipolysis products. J Biol Chem 267, 15198–15204.
Carneheim, C, Nedergaard, J, Cannon, B (1988): Cold-induced β-adrenergic recruitment of lipoprotein lipase in brown adipose tissue is due to increased transcription. Am J Physiol 254, E155-E161.
Carneheim, C, Alexson, S (1989): Refeeding and insulin increase lipoprotein lipase activity in rat brown adipose tissue. Am J Physiol 256, E645-E650.
Nedergaard, J (1982): Catecholamine sensitivity in brown fat cells from cold-adapted hamsters and rats. Am J Physiol 242, C250-C257.
Unelius, L, Bronnikov, G, Mohell, N, Nedergaard, J (1993): Physiological desensitization of ß3 adrenergic responsiveness in brown fat cells. Involvement of a post-receptor mechanism. Am J Physiol 265, C1340-C1348.
Revelli, J-P, Muzzin, P, Giacobino, J-P (1992): Modulation in vivo of β-adrenergic-receptor subtypes in rat brown adipose tissue by the thermogenic agonist Ro 16–8714. Biochem J 286,743–746.
Granneman, JG, Lahners, KN (1992): Differential adrenergic regulation of β1 and β3-adrenoceptor messenger ribonucleic acids in adipose tissues. Endocrinology 130,109–114.
Svoboda, P, Unelius, L, Cannon, B, Nedergaard, J (1993): Attenuation of Gs-protein coupling efficiency in brown adipose tissue plasma membranes from cold-acclimated hamsters. Biochem J 295, 655–661.
Unelius, L, Mohell, N, Nedergaard, J (1990): Cold acclimation induces desensitization to adenosine in brown fat cells without changing receptor binding. Am J Physiol 258, C818-C826.
Bronnikov, G, Houstek, J, Nedergaard, J (1992): β-Adrenergic, cAMP-mediated stimulation of proliferation of brown fat cells in primary culture. Mediation via β1 but not via β3 receptors. J Biol Chem 267, 2006–2013.
Rehnmark, S, Antonson, P, Xanthopoulos, KG, Jacobsson, A (1993): Differential adrenergic regulation of C/EBPa and C/EBPb in brown adipose tissue. FEBS Lett 318, 235–241.
Pappone, PA, Ortiz-Miranda, SI (1993): Blockers of voltage-gated K channels inhibit proliferation of cultured brown fat cells. Am J Physiol 264, C1014-C1019.
Lorenzo, M, Valverda, AM, Teruel, T, Benito, M (1993): IGF-1 is a mitogen involved in differentiation-related gene expression in fetal rat brown adipocytes. J Cell Biol 123, 1567–1575.
Rehnmark, S, Néchad, M, Herron, D, Cannon, B, Nedergaard, J (1990): α- and ß-adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture. J Biol Chem 265, 16464–16471.
Klaus, S, Casteilla, L, Bouillaud, F, Ricquier, D (1991): The uncoupling protein UCP: A membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue. Int J Biochem 23, 791–801.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Birkhäuser Verlag Basel
About this chapter
Cite this chapter
Cannon, B. et al. (1994). The Role of Adrenergic Stimulation in Regulation of Heat Production and Recruitment of Brown Adipose Tissue. In: Zeisberger, E., Schönbaum, E., Lomax, P. (eds) Thermal Balance in Health and Disease. APS Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7429-8_12
Download citation
DOI: https://doi.org/10.1007/978-3-0348-7429-8_12
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-0348-7431-1
Online ISBN: 978-3-0348-7429-8
eBook Packages: Springer Book Archive