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Structural and functional conservation of serotonin receptors throughout evolution

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Comparative Molecular Neurobiology

Part of the book series: EXS ((EXS,volume 63))

Summary

Pharmacological studies as well as molecular cloning of serotonin receptors have revealed a multiplicity of receptor subtypes not only in mammals but also in molluscs and arthropodes. Most of these receptors belong to the G protein-coupled receptor family and modulate levels of second messengers such as cAMP, IP3 and calcium.

Rather than being specialized in a particular physiological function, a given receptor may be expressed in multiple neurons throughout the brain but always in the same compartment of these neurons. The 5HT1B receptor for example, is generally localized presynaptically on neuronal terminals where it inhibits neurotransmitter release. A widespread distribution of 5-HT receptors might explain how serotonin can modulate the multiple neuronal circuits which underlie complex behaviors.

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Authors and Affiliations

  1. Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de l’INSERM, Faculté de Médecine, Institut de Chimie Biologique, F-67085, Strasbourg Cedex, France

    René Hen

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  1. René Hen
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Editors and Affiliations

  1. Equipe de Neurobiologie, C.N.R.S.-Université de Rennes I, Bât. 13-Complexe Univ. de Beaulieu, F-35042, Rennes Cedex, France

    Yves Pichon

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© 1993 Birkhäuser Verlag Basel/Switzerland

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Hen, R. (1993). Structural and functional conservation of serotonin receptors throughout evolution. In: Pichon, Y. (eds) Comparative Molecular Neurobiology. EXS, vol 63. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7265-2_14

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  • DOI: https://doi.org/10.1007/978-3-0348-7265-2_14

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7267-6

  • Online ISBN: 978-3-0348-7265-2

  • eBook Packages: Springer Book Archive

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