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Angiotensin Receptor Subtypes and their Pharmacology

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Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s

Summary

Angiotensin II (Ang II) is the principal mediator of the Renin-Angiotensin System, but other peptides may have a role, including Ang IV and Ang 1–7. Our understanding of Ang II receptor heterogeneity has been facilitated by the discovery of nonpeptide receptor antagonists and the cloning of Ang II receptor subtypes. Losartan-sensitivity defines AT, and PD123319 (and CGP42112)-sensitivity defines AT2 receptor subtypes. AT, receptors predominate in most mammalian tissues and subserve the well-known effects of Ang II. The AT2 receptors are abundant in fetal tissue, nonpregnant myometrium, discrete parts of brain, adrenal cortex and medulla, and kidney. The functional significance of the AT2 receptor is largely unknown, but may involve ion channels, “growth”, and cerebral autoregulation.

Tremendous strides have been made in understanding the structure, function, and diversity of Ang II receptors. These studies will continue to be facilitated by the advent of new receptor antagonists. Additional research is needed, however, to clarify the role of the mammalian AT2 site and the role of Ang 1–7 and Ang IV.

Review based on Symposium “Angiotensin Receptor Subtypes and Their Pharmacology” presented at IUPHAR’ 94, Montreal, Canada, July 26, 1994

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Author information

Authors and Affiliations

  1. Discovery Research, DuPont Merck Pharmaceutical Company, Experimental Station, P.O. Box 80400, Wilmington, DE, 19880-0400, USA

    Dr. Pieter B. M. W. M. Timmermans

  2. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA

    Tadishi Inagami

  3. Department of Health and Human Services, National Institutes of Health, Bethesda, MD, 20892, USA

    Juan M. Saavedra

  4. Service d’Explorations Fonctionnelles INSERM 64, Hôpital Tenon, Paris, France

    Raymond Ardaillou

  5. Department of Pediatrics, University of Texas, Southwestern Medical School, Dallas, TX, 75235, USA

    Charles R. Rosenfeld

  6. Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, 3084, Victoria, Australia

    Frederick A. O. Mendelsohn

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  1. Dr. Pieter B. M. W. M. Timmermans
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  2. Tadishi Inagami
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  3. Juan M. Saavedra
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  4. Raymond Ardaillou
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  5. Charles R. Rosenfeld
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  6. Frederick A. O. Mendelsohn
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Editors and Affiliations

  1. Department of Pharmacology and Therapeutics Mclntyre Medical Sciences Building, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6

    A. Claudio Cuello  & Brian Collier  & 

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Timmermans, P.B.M.W.M., Inagami, T., Saavedra, J.M., Ardaillou, R., Rosenfeld, C.R., Mendelsohn, F.A.O. (1995). Angiotensin Receptor Subtypes and their Pharmacology. In: Cuello, A.C., Collier, B. (eds) Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7218-8_5

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  • DOI: https://doi.org/10.1007/978-3-0348-7218-8_5

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7220-1

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