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Transport and Accumulation in Biological Cell Systems Interacting with Drugs

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Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrés des recherches pharmaceutiques

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Abstract

Experimental investigations on biological cell systems are in case of in vitro work often carried out with the help of cell suspensions, necessarily requiring a buffered, partly ‘inorganic’ medium. Such a procedure may of course involve a somewhat artifical situation, especially when living tissue regulation processes are the final goal of the description to be made. In this connection, one should realize that the dynamical basis of a purely phenomenological description of cell morphogenesis [1] as regulating its corresponding membrane transport does not conform to the same boundary conditions as those of cells incubated in a conditioning solution. However, in cell replication processes the code reading is always paralleled by a metabolic reaction catalyzed by the induced enzyme [2], so that an appreciable simplification can be reached by considering only a set of coupled metabolic reactions as driving forces of the biomembrane transport. Combining this with the idea that neurotransmitters may possess at least partially an inducer function and that their action can be either abolished or mimicked by drugs, the sections 2 and 3 of this paper have been outlined. The analytical method followed in these sections allows to reveal more specifically the action mechanism of some particular drugs, such as propranolol.

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    A. F. Bottse & W. Dorst

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Bottse, A.F., Dorst, W., Willems, G.M. (1976). Transport and Accumulation in Biological Cell Systems Interacting with Drugs. In: Jucker, E. (eds) Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrés des recherches pharmaceutiques. Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrés des recherches pharmaceutiques, vol 20. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7094-8_9

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  • DOI: https://doi.org/10.1007/978-3-0348-7094-8_9

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7096-2

  • Online ISBN: 978-3-0348-7094-8

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